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Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women

Journal Article · · International Journal of Cancer
DOI:https://doi.org/10.1002/ijc.32892· OSTI ID:1817172
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  1. Division of Genetics and Epidemiology The Institute of Cancer Research London United Kingdom
  2. Department of Epidemiology University of North Carolina Gillings School of Global Public Health Chapel Hill NC
  3. Institute of Cancer Research, London (United Kingdom)
  4. Biostatistics and Computational Biology Branch National Institute of Environmental Health Sciences, National Institutes of Health Durham NC
  5. Department of Medical Epidemiology and Biostatistics (MEB) Karolinska Institutet Stockholm Sweden; Clinical Effectiveness Research Group Institute of Health and Society, University of Oslo Oslo Norway
  6. Department of Clinical and Experimental Medicine University of Pisa Pisa Italy
  7. Department of Population Sciences Beckman Research Institute of City of Hope Duarte CA
  8. Slone Epidemiology Center at Boston University Boston MA
  9. Department of Population Health and Perlmutter Cancer Center New York University School of Medicine New York NY
  10. Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center Baltimore MD
  11. Nutrition and Metabolism Section International Agency for Research on Cancer Lyon France
  12. Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA; Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA
  13. Cancer Epidemiology and Intelligence Division Cancer Council Victoria Melbourne VIC Australia; Centre for Epidemiology and Biostatistics School of Population and Global Health, The University of Melbourne Melbourne VIC Australia
  14. Department of Community Medicine, Faculty of Health Sciences University of Tromsø (UiT), The Arctic University of Norway Tromsø Norway
  15. Department of Biostatistics and Epidemiology School of Public Health and Health Sciences, University of Massachusetts Amherst MA
  16. Division of Cancer Epidemiology, DKFZ Heidelberg Germany
  17. Nuffield Department of Population Health University of Oxford Oxford United Kingdom
  18. Ontario Institute for Cancer Research Toronto ON Canada
  19. Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD
  20. Karolinska Institute, Institute of Environmental Medicine Stockholm Sweden
  21. Radiation Effects Research Foundation Hiroshima Japan
  22. School of Public Health Imperial College London United Kingdom
  23. Albert Einstein College of Medicine Bronx NY
  24. Unit of Cancer Epidemiology Città della Salute e della Scienza University‐Hospital and Center for Cancer Prevention (CPO) Turin Italy
  25. Department of Surgical and Perioperative Sciences Umeå University Umeå Sweden
  26. Hellenic Health Foundation Athens Greece
  27. Cancer Registry of Norway, Institute of Population‐Based Cancer Research Oslo Norway; Institute of Basic Medical Sciences, University of Oslo Oslo Norway; Department of Preventive Medicine University of Southern California Los Angeles CA
  28. Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD; Johns Hopkins School of Medicine Baltimore MD
  29. International Agency for Research on Cancer (IARC)/World Health Organization (WHO) Lyon France
  30. Karolinska Institute, Institute of Environmental Medicine Stockholm Sweden; Department of Surgical Sciences Uppsala University Uppsala Sweden
  31. Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health Durham NC
  32. Division of Genetics and Epidemiology The Institute of Cancer Research London United Kingdom; Division of Breast Cancer Research The Institute of Cancer Research London United Kingdom
+ Show Author Affiliations
Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18–24 years and other breast cancer risk factors showed that weight gain from ages 18–24 to 35–44 or to 45–54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45–54: 0.96, 95% CI: 0.95–0.98) and with oestrogen-receptor(ER)-positive breast cancer (HR per 5 kg to ages 45–54: 0.96, 95% CI: 0.94–0.98). Weight gain from ages 25–34 was inversely associated with ER-positive breast cancer only and weight gain from ages 35–44 was not associated with risk. None of these weight gains were associated with ER-negative breast cancer. Weight loss was not consistently associated with overall or ER-specific risk after adjusting for initial weight. Weight increase from early-adulthood to ages 45–54 years is associated with a reduced premenopausal breast cancer risk independently of early-adulthood weight. Biological explanations are needed to account for these two separate factors.
Research Organization:
University of North Carolina, Chapel Hill, NC (United States)
Sponsoring Organization:
USDOE
Contributing Organization:
National Cancer Institute Cohort Consortium
OSTI ID:
1817172
Journal Information:
International Journal of Cancer, Journal Name: International Journal of Cancer Journal Issue: 5 Vol. 147; ISSN 0020-7136
Publisher:
WileyCopyright Statement
Country of Publication:
United States
Language:
English

References (41)

Anthropometry and breast cancer. Body size-a moving target journal August 1994
Associations between anthropometric characteristics, physical activity, and breast cancer risk in a Canadian cohort journal April 2014
Breast cancer risk accumulation starts early: prevention must also journal May 2014
Adiposity during early adulthood, changes in adiposity during adulthood, attained adiposity, and mammographic density among premenopausal women journal July 2017
Birthweight, early life body size and adult mammographic density: a review of epidemiologic studies journal July 2014
Long-term weight change and breast cancer risk: the European prospective investigation into cancer and nutrition (EPIC) journal August 2005
Body Fatness at Young Ages and Risk of Breast Cancer Throughout Life journal May 2010
Body Size in Early Life and Adult Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 journal August 2011
Testing for Gene-Environment Interactions Using a Prospective Family Cohort Design: Body Mass Index in Early and Later Adulthood and Risk of Breast Cancer journal February 2017
Body mass index and breast cancer risk in Japan: a pooled analysis of eight population-based cohort studies journal February 2014
Predictors of Ovarian Steroid Secretion in Reproductive-Age Women journal August 1996
A Prospective Study of Body Size in Different Periods of Life and Risk of Premenopausal Breast Cancer journal July 2004
Birthweight and Body Size throughout Life in Relation to Sex Hormones and Prolactin Concentrations in Premenopausal Women journal December 2006
Dual Effects of Weight and Weight Gain on Breast Cancer Risk journal November 1997
Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women journal November 2018
Body mass and stage of breast cancer at diagnosis journal February 2002
Body weight at age 20 years, subsequent weight change and breast cancer risk defined by estrogen and progesterone receptor status-the Japan public health center-based prospective study journal April 2011
Adult weight change and incidence of premenopausal breast cancer journal May 2011
Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study journal May 2014
Prospective cohort study of general and central obesity, weight change trajectory and risk of major cancers among Chinese women: Cohort study of obesity and cancer risk journal May 2016
Weight and weight changes in early adulthood and later breast cancer risk journal March 2017
Body weight and risk of breast cancer in BRCA1/2 mutation carriers journal August 2010
Reduced progesterone levels explain the reduced risk of breast cancer in obese premenopausal women: a new hypothesis journal November 2014
Short-term weight gain and breast cancer risk by hormone receptor classification among pre- and postmenopausal women journal March 2015
Adiposity Results in Metabolic and Inflammation Differences in Premenopausal and Postmenopausal Women Consistent with the Difference in Breast Cancer Risk journal March 2018
Tallness and overweight during childhood have opposing effects on breast cancer risk journal November 2001
Health Effects of Overweight and Obesity in 195 Countries over 25 Years journal July 2017
Body mass index and survival in women with breast cancer—systematic literature review and meta-analysis of 82 follow-up studies journal October 2014
Adult Weight Gain and Adiposity-Related Cancers: A Dose-Response Meta-Analysis of Prospective Observational Studies journal January 2015
Regression Models and Life-Tables journal January 1972
Birthweight and Body Size throughout Life in Relation to Sex Hormones and Prolactin Concentrations in Premenopausal Women journal December 2006
A Prospective Study of Body Size and Breast Cancer in Black Women journal September 2007
The Premenopausal Breast Cancer Collaboration: A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium journal August 2017
Estrogen Metabolism in Premenopausal Women Is Related to Early Life Body Fatness journal April 2018
Group-based multi-trajectory modeling journal October 2016
Mammographic density and breast cancer risk: a mediation analysis journal September 2016
Lifetime body size and estrogen-receptor-positive breast cancer risk in the California Teachers Study cohort journal December 2016
Applying Cox Regression to Competing Risks journal June 1995
Impact of body mass index on breast cancer in accordance with the life-stage of women journal January 2012
Mammographic density and breast cancer risk: a mediation analysis collection January 2016
Weight Gain and Alcohol Drinking Associations with Breast Cancer Risk in Japanese Postmenopausal Women - Results from the Japan Collaborative Cohort (JACC) Study journal April 2016

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Related Subjects

60 APPLIED LIFE SCIENCES
body weight changes
breast neoplasms
cohort studies
premenopause
risk factors