skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Longitudinal changes in red blood cell distribution width decades after radiation exposure in atomic–bomb survivors

Journal Article · · British Journal of Haematology
DOI:https://doi.org/10.1111/bjh.17296· OSTI ID:1816290
ORCiD logo [1]; ORCiD logo [2];  [1];  [3]
  1. Radiation Effects Research Foundation (RERF), Hiroshima (Japan). Department of Molecular Biosciences
  2. Radiation Effects Research Foundation (RERF), Hiroshima (Japan). Department of Statistics
  3. Radiation Effects Research Foundation (RERF), Hiroshima (Japan). Department of Clinical Studies
+ Show Author Affiliations

Red blood cell distribution width (RDW), which generally increases with age, is a risk marker for morbidity and mortality in various diseases. We investigated the association between elevated RDW and prior radiation exposure by examining longitudinal RDW changes in 4204 atomic-bomb survivors over 15 years. A positive association was found between RDW and radiation dose, wherein RDW increased by 0·18%/Gy. This radiation-associated effect increased as the participants aged. Elevated RDW was also associated with higher all-cause mortality. The biological mechanisms underlying these observed associations merit further investigation.

Research Organization:
Radiation Effects Research Foundation (RERF), Hiroshima (Japan)
Sponsoring Organization:
USDOE; Japanese Ministry of Health, Labour and Welfare (MHLW)
OSTI ID:
1816290
Journal Information:
British Journal of Haematology, Vol. 193, Issue 2; ISSN 0007-1048
Publisher:
Wiley - British Society for HaematologyCopyright Statement
Country of Publication:
United States
Language:
English

References (15)

Red blood cell distribution width: A simple parameter with multiple clinical applications journal December 2014
Red Cell Distribution Width and Mortality in Older Adults: A Meta-analysis journal October 2009
Increased red cell distribution width is associated with poor stem cell mobilization in patients with advanced chronic heart failure journal October 2015
Radiation Sensitivity of Human Erythropoietic and Granulopoietic Progenitor Cells in the Blood and in the Bone Marrow
  • Grilli, Gualtiero; Nothdurft, Wilhelm; Fliedner, Theodor M.
  • International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 41, Issue 6 https://doi.org/10.1080/09553008214550781
journal January 1982
Studies of the Mortality of Atomic Bomb Survivors, Report 14, 1950–2003: An Overview of Cancer and Noncancer Diseases journal March 2012
Somatic Cell Mutations at the Glycophorin A Locus in Erythrocytes of Atomic Bomb Survivors: Implications for Radiation Carcinogenesis journal July 1996
Effects of Radiation on the Longitudinal Trends of Hemoglobin Levels in the Japanese Atomic Bomb Survivors journal December 2005
A Long-Term Cohort Study of the Atomic-Bomb Survivors journal January 1996
DS02R1: Improvements to Atomic Bomb Survivors’ Input Data and Implementation of Dosimetry System 2002 (DS02) and Resulting Changes in Estimated Doses journal January 2017
JM : An R Package for the Joint Modelling of Longitudinal and Time-to-Event Data journal January 2010
Prediction of acute myeloid leukaemia risk in healthy individuals journal July 2018
Radiation exposure and longitudinal changes in peripheral monocytes over 50 years: the Adult Health Study of atomic‐bomb survivors journal January 2019
Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes journal December 2014
Estimating the Number of Hematopoietic or Lymphoid Stem Cells Giving Rise to Clonal Chromosome Aberrations in Blood T Lymphocytes journal March 2004
Environmental influences on clonal hematopoiesis journal March 2020

Similar Records

Radiation exposure and longitudinal changes in peripheral monocytes over 50 years: the Adult Health Study of atomic‐bomb survivors
Journal Article · Sun Jan 13 00:00:00 EST 2019 · British Journal of Haematology · OSTI ID:1816290
+3 more
Association Between Prevalence of Peripheral Artery Disease and Radiation Exposure in the Atomic Bomb Survivors
Journal Article · Tue Dec 04 00:00:00 EST 2018 · Journal of the American Heart Association · OSTI ID:1816290
+8 more
Breast cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with breast cancer mortality in the atomic bomb survivors study
Journal Article · Sat Jun 01 00:00:00 EDT 1996 · Radiation Research · OSTI ID:1816290

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.