Surface Feature-Guided Mapping of Cerebral Metabolic Changes in Cognitively Normal and Mildly Impaired Elderly

Apostolova, Liana G.; Thompson, Paul M.; Rogers, Steve A.; Dinov, Ivo D.; Zoumalan, Charleen; Steiner, Calen A.; Siu, Erin; Green, Amity E.; Small, Gary W.; Toga, Arthur W.; Cummings, Jeffrey L.; Phelps, Michael E.; Silverman, Daniel H.

doi:10.1007/s11307-009-0247-7

Surface Feature-Guided Mapping of Cerebral Metabolic Changes in Cognitively Normal and Mildly Impaired Elderly

Journal Article · Tue Jul 28 00:00:00 EDT 2009 · Molecular Imaging and Biology

DOI:https://doi.org/10.1007/s11307-009-0247-7· OSTI ID:1816151

Apostolova, Liana G. ^[1]; Thompson, Paul M. ^[2]; Rogers, Steve A. ^[3]; Dinov, Ivo D. ^[4]; Zoumalan, Charleen ^[5]; Steiner, Calen A. ^[5]; Siu, Erin ^[6]; Green, Amity E. ^[2]; Small, Gary W. ^[7]; Toga, Arthur W. ^[2]; Cummings, Jeffrey L. ^[8]; Phelps, Michael E. ^[6]; Silverman, Daniel H. ^[6]

Univ. of California, Los Angeles, CA (United States). David Geffen School of Medicine. Dept. of Neurology; Univ. of California, Los Angeles, CA (United States). Lab. of Neuroimaging; OSTI
Univ. of California, Los Angeles, CA (United States). David Geffen School of Medicine. Dept. of Neurology; Univ. of California, Los Angeles, CA (United States). Lab. of Neuroimaging
Westmont College, Santa Barbara, CA (United States)
Univ. of California, Los Angeles, CA (United States). Lab. of Neuroimaging; Univ. of California, Los Angeles, CA (United States). Dept. of Statistics
Univ. of California, Los Angeles, CA (United States). David Geffen School of Medicine. Dept. of Neurology
Univ. of California, Los Angeles, CA (United States). David Geffen School of Medicine. Dept. of Molecular and Medical Pharmacology
Univ. of California, Los Angeles, CA (United States). David Geffen School of Medicine. Dept. of Psychiatry and Biobehavioral Sciences; Univ. of California, Los Angeles, CA (United States). Semel Inst. for Neuroscience and Human Behavior
Univ. of California, Los Angeles, CA (United States). David Geffen School of Medicine. Dept. of Neurology; Univ. of California, Los Angeles, CA (United States). David Geffen School of Medicine. Dept. of Psychiatry and Biobehavioral Sciences

The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly. Procedures: Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4±0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deoxy-2-[F-18]fluoroD-glucose (FDG)-PET scan (interval 21.7±3.7 months), baseline structural 3T magnetic resonance (MR) imaging, and apolipoprotein E4 genotyping. Cortical PET metabolic changes were analyzed in 3-D using the cortical pattern matching technique. Baseline vs. follow-up whole-group comparison revealed significant metabolic decline bilaterally in the posterior temporal, parietal, and occipital lobes and the left lateral frontal cortex. The declining group demonstrated 10–15% decline in bilateral posterior cingulate/precuneus, posterior temporal, parietal, and occipital cortices. The cognitively stable group showed 2.5–5% similarly distributed decline. ApoE4-positive individuals underwent 5–15% metabolic decline in the posterior association cortices. Using 3-D surface-based MR-guided FDG-PET mapping, significant metabolic changes were seen in five posterior and the left lateral frontal regions. The changes were more pronounced for the declining relative to the cognitively stable group.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of California, Los Angeles, CA (United States)

Sponsoring Organization:: NIA; NIBIB; National Institutes of Health (NIH); USDOE Office of Science (SC)

Grant/Contract Number:: FC03-87ER60615

OSTI ID:: 1816151

Journal Information:: Molecular Imaging and Biology, Journal Name: Molecular Imaging and Biology Journal Issue: 2 Vol. 12; ISSN 1536-1632

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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