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Title: Glove-based sensors for multimodal monitoring of natural sweat

Journal Article · · Science Advances

Sweat sensors targeting exercise or chemically induced sweat have shown promise for noninvasive health monitoring. Natural thermoregulatory sweat is an attractive alternative as it can be accessed during routine and sedentary activity without impeding user lifestyles and potentially preserves correlations between sweat and blood biomarkers. We present simple glove-based sensors to accumulate natural sweat with minimal evaporation, capitalizing on high sweat gland densities to collect hundreds of microliters in just 30 min without active sweat stimulation. Sensing electrodes are patterned on nitrile gloves and finger cots for in situ detection of diverse biomarkers, including electrolytes and xenobiotics, and multiple gloves or cots are worn in sequence to track overarching analyte dynamics. Direct integration of sensors into gloves represents a simple and low-overhead scheme for natural sweat analysis, enabling sweat-based physiological monitoring to become practical and routine without requiring highly complex or miniaturized components for analyte collection and signal transduction.

Research Organization:
Univ. of California, Berkeley, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
Grant/Contract Number:
AC02-05CH11231
OSTI ID:
1816091
Journal Information:
Science Advances, Vol. 6, Issue 35; ISSN 2375-2548
Publisher:
AAASCopyright Statement
Country of Publication:
United States
Language:
English

References (45)

The Excretion of Ascorbic acid and Dehydroascorbic acid in Sweat and Urine Under Different Environmental Conditions journal November 1945
Wearable biosensors for healthcare monitoring journal February 2019
A wearable patch for continuous monitoring of sweat electrolytes during exertion journal January 2018
Mechanisms of reversible stretchability of thin metal films on elastomeric substrates journal May 2006
Wearable Electrochemical Sensors and Biosensors: A Review journal September 2012
The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications journal May 2015
Prolonged and localized sweat stimulation by iontophoretic delivery of the slowly-metabolized cholinergic agent carbachol journal January 2018
Sweating-Physiology and Pathophysiology journal December 1976
Excitation and depression of eccrine sweat glands by acetylcholine, acetyl-β-methylcholine and adrenaline journal October 1959
The regional distribution of sweating journal June 1945
Regional variations in transepidermal water loss, eccrine sweat gland density, sweat secretion rates and electrolyte composition in resting and exercising humans journal February 2013
Simultaneous lancet-free monitoring of alcohol and glucose from low-volumes of perspired human sweat journal April 2018
Enhancing glucose flux into sweat by increasing paracellular permeability of the sweat gland journal July 2018
Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis journal January 2016
Wearable sweat sensors journal March 2018
Sweat Ethanol Concentrations are Highly Correlated with Co-Existing Blood Values in Humans journal March 1999
A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat journal November 2016
Flexible thick-film glucose biosensor: Influence of mechanical bending on the performance journal April 2010
Natural Perspiration Sampling and in Situ Electrochemical Analysis with Hydrogel Micropatches for User-Identifiable and Wireless Chemo/Biosensing journal December 2019
A Bromphenol Blue Method for Visualizing Sweat at the Openings of the Sweat Ducts**From the Physiological Laboratory, Tohoku University School of Medicine, Sendai, Japan. journal January 1961
Stretchable gold conductors embedded in PDMS and patterned by photolithography: fabrication and electromechanical characterization journal April 2010
Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System journal July 2016
Gender-linked differences in human skin journal September 2009
Modified iodine-paper technique for the standardized determination of sweat gland activation journal April 2012
Biomechanical performance of powder-free examination gloves journal November 1999
Wearable Sweat Band for Noninvasive Levodopa Monitoring journal August 2019
Neural control of sweat secretion: a review journal April 2018
Methylxanthine Drug Monitoring with Wearable Sweat Sensors journal April 2018
Complete validation of a continuous and blood-correlated sweat biosensing device with integrated sweat stimulation journal January 2018
Epidermal Microfluidic Electrochemical Detection System: Enhanced Sweat Sampling and Metabolite Detection journal December 2017
Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform journal April 2017
Effect of induced metabolic alkalosis on sweat composition in men: Alkalosis and sweat composition journal January 2002
Acid-Base Balance in Sweat journal August 1932
A novel non-invasive electrochemical biosensing device for in situ determination of the alcohol content in blood by monitoring ethanol in sweat journal January 2014
A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat journal November 2019
Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use journal April 2004
Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat journal August 2019
Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat journal January 2019
Porous Enzymatic Membrane for Nanotextured Glucose Sweat Sensors with High Stability toward Reliable Noninvasive Health Monitoring journal June 2019
Accessing analytes in biofluids for peripheral biochemical monitoring journal February 2019
Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids journal May 2016
Integrated sudomotor axon reflex sweat stimulation for continuous sweat analyte analysis with individuals at rest journal January 2017
A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca 2+ and pH journal July 2016
Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module journal March 2017
Flexible thick-film electrochemical sensors: Impact of mechanical bending and stress on the electrochemical behavior journal March 2009

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