Salivary microbiome composition changes after bariatric surgery

Džunková, Mária; Lipták, Róbert; Vlková, Barbora; Gardlík, Roman; Čierny, Michal; Moya, Andrés; Celec, Peter

doi:10.1038/s41598-020-76991-6

Salivary microbiome composition changes after bariatric surgery

Journal Article · Wed Nov 18 04:00:00 EST 2020 · Scientific Reports

DOI:https://doi.org/10.1038/s41598-020-76991-6· OSTI ID:1816072

Džunková, Mária ^[1]; Lipták, Róbert ^[2]; Vlková, Barbora ^[2]; Gardlík, Roman ^[2]; Čierny, Michal ^[3]; Moya, Andrés ^[4]; Celec, Peter ^[2]

USDOE Joint Genome Institute (JGI), Berkeley, CA (United States); OSTI
Comenius Univ., Bratislava (Slovakia)
Břeclav Hospital, Břeclav (Czech Republic)
Foundation for the Promotion of Sanitary and Biomedical Research of Valencian Community (FISABIO-Public Health), Valencia (Spain); CIBER in Epidemiology and Public Health (CIBEResp), Madrid (Spain); Univ. of Valencia and Spanish National Research Council (CSIC), Valencia (Spain)

Recent studies show that the salivary microbiome in subjects with obesity differ from those without obesity, but the mechanism of interaction between the salivary microbiome composition and body weight is unclear. Herein we investigate this relation by analyzing saliva samples from 35 adult patients with obesity undergoing bariatric surgery. Our aim was to describe salivary microbiome changes during body weight loss on an individual-specific level, and to elucidate the effect of bariatric surgery on the salivary microbiome which has not been studied before. Analysis of samples collected before and 1 day after surgery, as well as 3 and 12 months after surgery, showed that the salivary microbiome changed in all study participants, but these changes were heterogeneous. In the majority of participants proportions of Gemella species, Granulicatella elegans, Porphyromonas pasteri, Prevotella nanceiensis and Streptococcus oralis decreased, while Veillonella species, Megasphaera micronuciformis and Prevotella saliva increased. Nevertheless, we found participants deviating from this general trend which suggests that a variety of individual-specific factors influence the salivary microbiome composition more effectively than the body weight dynamics alone. The observed microbiome alternations could be related to dietary changes. Therefore, further studies should focus on association with altered taste preferences and potential oral health consequences.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC); Spanish Ministry of Science and Innovation; Generalitat Valenciana; European Regional Development Fund (ERDF); Ministry of Health of the Slovak Republic; Ministry of Education of the Slovak Republic; Slovak Research and Development Agency

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1816072

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 10; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

References (48)

Impact of Bariatric Surgery on the Saliva of Patients with Morbid Obesity Hashizume, Lina N.; Bastos, Lucelen F.; Cardozo, Débora D. Obesity Surgery, Vol. 25, Issue 8 https://doi.org/10.1007/s11695-015-1741-4	journal	May 2015
Oral pH in gastroesophageal reflux disease Sujatha, S.; Jalihal, Umesh; Devi, Yashoda Indian Journal of Gastroenterology, Vol. 35, Issue 3 https://doi.org/10.1007/s12664-016-0659-7	journal	May 2016
The Epidemiology of Obesity: A Big Picture Hruby, Adela; Hu, Frank B. PharmacoEconomics, Vol. 33, Issue 7 https://doi.org/10.1007/s40273-014-0243-x	journal	December 2014
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013 Ng, Marie; Fleming, Tom; Robinson, Margaret The Lancet, Vol. 384, Issue 9945 https://doi.org/10.1016/S0140-6736(14)60460-8	journal	August 2014
Salivary microbiome in non-oral disease: A summary of evidence and commentary Acharya, Aneesha; Chan, Yuki; Kheur, Supriya Archives of Oral Biology, Vol. 83 https://doi.org/10.1016/j.archoralbio.2017.07.019	journal	November 2017
Metabolic surgery: Action via hormonal milieu changes, changes in bile acids or gut microbiota? A summary of the literature Sweeney, Timothy E.; Morton, John M. Best Practice & Research Clinical Gastroenterology, Vol. 28, Issue 4 https://doi.org/10.1016/j.bpg.2014.07.016	journal	August 2014
Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation Tremaroli, Valentina; Karlsson, Fredrik; Werling, Malin Cell Metabolism, Vol. 22, Issue 2 https://doi.org/10.1016/j.cmet.2015.07.009	journal	August 2015
Altered gut microbiome after bariatric surgery and its association with metabolic benefits: A systematic review Davies, Naomi K.; O'Sullivan, Justin M.; Plank, Lindsay D. Surgery for Obesity and Related Diseases, Vol. 15, Issue 4 https://doi.org/10.1016/j.soard.2019.01.033	journal	April 2019
Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding Ilhan, Zehra Esra; DiBaise, John K.; Isern, Nancy G. The ISME Journal, Vol. 11, Issue 9 https://doi.org/10.1038/ismej.2017.71	journal	May 2017
An obesity-associated gut microbiome with increased capacity for energy harvest Turnbaugh, Peter J.; Ley, Ruth E.; Mahowald, Michael A. Nature, Vol. 444, Issue 7122 https://doi.org/10.1038/nature05414	journal	December 2006
Strains, functions and dynamics in the expanded Human Microbiome Project Lloyd-Price, Jason; Mahurkar, Anup; Rahnavard, Gholamali Nature, Vol. 550, Issue 7674 https://doi.org/10.1038/nature23889	journal	September 2017
Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour Fetissov, Sergueï O. Nature Reviews Endocrinology, Vol. 13, Issue 1 https://doi.org/10.1038/nrendo.2016.150	journal	September 2016
The gut microbiota and obesity: from correlation to causality Zhao, Liping Nature Reviews Microbiology, Vol. 11, Issue 9 https://doi.org/10.1038/nrmicro3089	journal	August 2013
Microbiota in the Oral Subgingival Biofilm Is Associated With Obesity in Adolescence Zeigler, Cecilia C.; Persson, G. Rutger; Wondimu, Biniyam Obesity, Vol. 20, Issue 1 https://doi.org/10.1038/oby.2011.305	journal	October 2011
Gut microbiota: a new path to treat obesity Muscogiuri, Giovanna; Cantone, Elena; Cassarano, Sara International Journal of Obesity Supplements, Vol. 9, Issue 1 https://doi.org/10.1038/s41367-019-0011-7	journal	April 2019
Meta-analysis of gut microbiome studies identifies disease-specific and shared responses Duvallet, Claire; Gibbons, Sean M.; Gurry, Thomas Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-01973-8	journal	December 2017
Inter-personal diversity and temporal dynamics of dental, tongue, and salivary microbiota in the healthy oral cavity Hall, Michael W.; Singh, Natasha; Ng, Kester F. npj Biofilms and Microbiomes, Vol. 3, Issue 1 https://doi.org/10.1038/s41522-016-0011-0	journal	January 2017
Oxidative stress in the oral cavity is driven by individual-specific bacterial communities Džunková, Mária; Martinez-Martinez, Daniel; Gardlík, Roman npj Biofilms and Microbiomes, Vol. 4, Issue 1 https://doi.org/10.1038/s41522-018-0072-3	journal	November 2018
The role of short-chain fatty acids in microbiota–gut–brain communication Dalile, Boushra; Van Oudenhove, Lukas; Vervliet, Bram Nature Reviews Gastroenterology & Hepatology, Vol. 16, Issue 8 https://doi.org/10.1038/s41575-019-0157-3	journal	May 2019
The salivary microbiome is consistent between subjects and resistant to impacts of short-term hospitalization Cabral, Damien J.; Wurster, Jenna I.; Flokas, Myrto E. Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-11427-2	journal	September 2017
New insights into the relationship between taste perception and oral microbiota composition Cattaneo, Camilla; Gargari, Giorgio; Koirala, Ranjan Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-40374-3	journal	March 2019
Roux-Y Gastric Bypass and Sleeve Gastrectomy directly change gut microbiota composition independent of surgery type Paganelli, Fernanda L.; Luyer, Misha; Hazelbag, C. Marijn Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-47332-z	journal	July 2019
Weight and Metabolic Outcomes 12 Years after Gastric Bypass Adams, Ted D.; Davidson, Lance E.; Litwin, Sheldon E. New England Journal of Medicine, Vol. 377, Issue 12 https://doi.org/10.1056/NEJMoa1700459	journal	September 2017
Physiology, pathophysiology and therapeutic implications of enteroendocrine control of food intake Elliott, Jessie A.; Reynolds, John V.; le Roux, Carel W. Expert Review of Endocrinology & Metabolism, Vol. 11, Issue 6 https://doi.org/10.1080/17446651.2016.1245140	journal	September 2016
Association of the oral microbiome with the progression of impaired fasting glucose in a Chinese elderly population Wang, Rui-Rui; Xu, Yue-Song; Ji, Meng-Meng Journal of Oral Microbiology, Vol. 11, Issue 1 https://doi.org/10.1080/20002297.2019.1605789	journal	January 2019
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data Robinson, M. D.; McCarthy, D. J.; Smyth, G. K. Bioinformatics, Vol. 26, Issue 1 https://doi.org/10.1093/bioinformatics/btp616	journal	November 2009
Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies Klindworth, Anna; Pruesse, Elmar; Schweer, Timmy Nucleic Acids Research, Vol. 41, Issue 1 https://doi.org/10.1093/nar/gks808	journal	August 2012
Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities Schloss, P. D.; Westcott, S. L.; Ryabin, T. Applied and Environmental Microbiology, Vol. 75, Issue 23, p. 7537-7541 https://doi.org/10.1128/AEM.01541-09	journal	October 2009
Defining Microbiome Health through a Host Lens Gibbons, Sean M. mSystems, Vol. 4, Issue 3 https://doi.org/10.1128/mSystems.00155-19	journal	June 2019
Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk Li, J. V.; Ashrafian, H.; Bueter, M. Gut, Vol. 60, Issue 9 https://doi.org/10.1136/gut.2010.234708	journal	May 2011
Major microbiota dysbiosis in severe obesity: fate after bariatric surgery Aron-Wisnewsky, Judith; Prifti, Edi; Belda, Eugeni Gut, Vol. 68, Issue 1 https://doi.org/10.1136/gutjnl-2018-316103	journal	June 2018
Effects of Surgical and Dietary Weight Loss Therapy for Obesity on Gut Microbiota Composition and Nutrient Absorption Damms-Machado, Antje; Mitra, Suparna; Schollenberger, Asja E. BioMed Research International, Vol. 2015 https://doi.org/10.1155/2015/806248	journal	January 2015
Bariatric Surgery: Risks and Rewards Pories, Walter J. The Journal of Clinical Endocrinology & Metabolism, Vol. 93, Issue 11_supplement_1 https://doi.org/10.1210/jc.2008-1641	journal	November 2008
The salivary microbiome is altered in the presence of a high salivary glucose concentration Goodson, J. Max; Hartman, Mor-Li; Shi, Ping PLOS ONE, Vol. 12, Issue 3 https://doi.org/10.1371/journal.pone.0170437	journal	March 2017
Salivary inflammatory markers and microbiome in normoglycemic lean and obese children compared to obese children with type 2 diabetes Janem, Waleed F.; Scannapieco, Frank A.; Sabharwal, Amarpeet PLOS ONE, Vol. 12, Issue 3 https://doi.org/10.1371/journal.pone.0172647	journal	March 2017
Oral microbiota reveals signs of acculturation in Mexican American women Hoffman, Kristi L.; Hutchinson, Diane S.; Fowler, Jerry PLOS ONE, Vol. 13, Issue 4 https://doi.org/10.1371/journal.pone.0194100	journal	April 2018
The effect of bariatric surgery on gastroesophageal reflux disease [EN] El-Hadi, Mustafa; Birch, Daniel; Gill, Richdeep Canadian Journal of Surgery, Vol. 57, Issue 2 https://doi.org/10.1503/cjs.030612	journal	April 2014
Modulation of the gut microbiome: a systematic review of the effect of bariatric surgery Guo, Yan; Huang, Zhi-Ping; Liu, Chao-Qian European Journal of Endocrinology, Vol. 178, Issue 1 https://doi.org/10.1530/EJE-17-0403	journal	January 2018
Interfaces between bariatric surgery and oral health: a longitudinal survey Marsicano, Juliane Avansini; Grec, Patrícia Garcia de Moura; Belarmino, Lídia Barbieri Acta Cirurgica Brasileira, Vol. 26, Issue suppl 2 https://doi.org/10.1590/S0102-86502011000800015	journal	January 2011
Acquiring and maintaining a normal oral microbiome: current perspective Zaura, Egija; Nicu, Elena A.; Krom, Bastiaan P. Frontiers in Cellular and Infection Microbiology, Vol. 4 https://doi.org/10.3389/fcimb.2014.00085	journal	June 2014
Alterations of the Gut Microbiome in Hypertension Yan, Qiulong; Gu, Yifang; Li, Xiangchun Frontiers in Cellular and Infection Microbiology, Vol. 7 https://doi.org/10.3389/fcimb.2017.00381	journal	August 2017
Gender-Specific Associations Between Saliva Microbiota and Body Size Raju, Sajan C.; Lagström, Sonja; Ellonen, Pekka Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.00767	journal	April 2019
Cross-Regional View of Functional and Taxonomic Microbiota Composition in Obesity and Post-obesity Treatment Shows Country Specific Microbial Contribution Medina, Daniel A.; Li, Tianlu; Thomson, Pamela Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.02346	journal	October 2019
The oral microflora in obesity and type-2 diabetes Shillitoe, Edward; Weinstock, Ruth; Kim, Taewan Journal of Oral Microbiology, Vol. 4, Issue 1 https://doi.org/10.3402/jom.v4i0.19013	journal	January 2012
Nutritional Recommendations for Adult Bariatric Surgery Patients: Clinical Practice Sherf Dagan, Shiri; Goldenshluger, Ariela; Globus, Inbal Advances in Nutrition: An International Review Journal, Vol. 8, Issue 2 https://doi.org/10.3945/an.116.014258	journal	March 2017
Metabolic surgery for treating type 2 diabetes mellitus: Now supported by the world’s leading diabetes organizations Schauer, Philip R.; Hanipah, Zubaidah Nor; Rubino, Francesco Cleveland Clinic Journal of Medicine, Vol. 84, Issue 7 suppl 1 https://doi.org/10.3949/ccjm.84.s1.06	journal	July 2017
VSEARCH: a versatile open source tool for metagenomics Rognes, Torbjørn; Flouri, Tomáš; Nichols, Ben PeerJ, Vol. 4 https://doi.org/10.7717/peerj.2584	journal	January 2016
Characterization of the salivary microbiome in people with obesity Wu, Yujia; Chi, Xiaopei; Zhang, Qian PeerJ, Vol. 6 https://doi.org/10.7717/peerj.4458	journal	January 2018

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