Addressing Parental Vaccine Hesitancy and Other Barriers to Childhood/Adolescent Vaccination Uptake During the Coronavirus (COVID-19) Pandemic

Olusanya, Olufunto A.; Bednarczyk, Robert A.; Davis, Robert L.; Shaban-Nejad, Arash

doi:10.3389/fimmu.2021.663074

Addressing Parental Vaccine Hesitancy and Other Barriers to Childhood/Adolescent Vaccination Uptake During the Coronavirus (COVID-19) Pandemic

Journal Article · Thu Mar 18 00:00:00 EDT 2021 · Frontiers in Immunology

DOI:https://doi.org/10.3389/fimmu.2021.663074· OSTI ID:1815900

Olusanya, Olufunto A. ^[1]; Bednarczyk, Robert A. ^[2]; Davis, Robert L. ^[3]; Shaban-Nejad, Arash ^[3]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Biomedical Informatics; Univ. of Tennessee, Memphis, TN (United States). Health Science Center. College of Medicine. School of Medicine. Dept. of Pediatrics; OSTI
Emory Univ., Atlanta, GA (United States). Rollins School of Public Health. Hubert Dept. of Global Health
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Biomedical Informatics; Univ. of Tennessee, Memphis, TN (United States). Health Science Center. College of Medicine. School of Medicine. Dept. of Pediatrics

Routine childhood immunizations are proven to be one of the most effective public health interventions at controlling numerous deadly diseases. Therefore, the CDC recommends routine immunizations for children and adolescent populations against vaccine-preventable diseases e.g., tetanus, pertussis, diphtheria, etc. This current review sought to examine barriers to pediatric vaccine uptake behaviors during the COVID-19 pandemic. We also explored the implications for parental vaccine hesitancy/delay during an ongoing health crisis and proposed recommendations for increasing vaccine confidence and compliance. Our review determined that the receipt for vaccinations steadily improved in the last decade for both the United States and Tennessee. However, this incremental progress has been forestalled by the COVID-19 pandemic and other barriers i.e. parental vaccine hesitancy, social determinants of health (SDoH) inequalities, etc. which further exacerbate vaccination disparities. Moreover, non-compliance to routine vaccinations could cause an outbreak of diseases, thereby, worsening the ongoing health crisis and already strained health care system. Healthcare providers are uniquely positioned to offer effective recommendations with presumptive languaging to increase vaccination rates, as well as, address parental vaccine hesitancy. Best practices that incorporate healthcare providers’ quality improvement coaching, vaccination reminder recall systems, adherence to standardized safety protocols (physical distancing, hand hygiene practices, etc.), as well as, offer telehealth and outdoor/drive-through/curbside vaccination services, etc. are warranted. Additionally, a concerted effort should be made to utilize public health surveillance systems to collect, analyze, and interpret data, thereby, ensuring the dissemination of timely, accurate health information for effective health policy decision-making e.g., vaccine distribution, etc.

View Accepted Manuscript (DOE)

Sponsoring Organization:: National Cancer Institute (NCI); USDOE Office of Science (SC)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1815900

Journal Information:: Frontiers in Immunology, Journal Name: Frontiers in Immunology Vol. 12; ISSN 1664-3224

Publisher:: Frontiers Research FoundationCopyright Statement

Country of Publication:: United States

Language:: English

References (38)

Association Between Vaccine Refusal and Vaccine-Preventable Diseases in the United States: A Review of Measles and Pertussis Phadke, Varun K.; Bednarczyk, Robert A.; Salmon, Daniel A. JAMA, Vol. 315, Issue 11 https://doi.org/10.1001/jama.2016.1353	journal	March 2016
Vaccine Refusal and Measles Outbreaks in the US Phadke, Varun K.; Bednarczyk, Robert A.; Omer, Saad B. JAMA, Vol. 324, Issue 13 https://doi.org/10.1001/jama.2020.14828	journal	October 2020
Nonmedical Exemptions to School Immunization Requirements: Secular Trends and Association of State Policies With Pertussis Incidence Omer, Saad B.; Pan, William K. Y.; Halsey, Neal A. JAMA, Vol. 296, Issue 14 https://doi.org/10.1001/jama.296.14.1757	journal	October 2006
FDA approves Gardasil 9 for more types of HPV Printz, Carrie Cancer, Vol. 121, Issue 8 https://doi.org/10.1002/cncr.29374	journal	April 2015
Serological Association of Measles Virus and Human Herpesvirus-6 with Brain Autoantibodies in Autism Singh, Vijendra K.; Lin, Sheren X.; Yang, Victor C. Clinical Immunology and Immunopathology, Vol. 89, Issue 1 https://doi.org/10.1006/clin.1998.4588	journal	October 1998
Social Determinants of Health and Human Papillomavirus Vaccination Among Young Adults, National Health Interview Survey 2016 Thompson, Erika L.; Rosen, Brittany L.; Maness, Sarah B. Journal of Community Health, Vol. 44, Issue 1 https://doi.org/10.1007/s10900-018-0565-2	journal	August 2018
RETRACTED: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children Wakefield, Aj; Murch, Sh; Anthony, A. The Lancet, Vol. 351, Issue 9103 https://doi.org/10.1016/S0140-6736(97)11096-0	journal	February 1998
Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association Taylor, Brent; Miller, Elizabeth; Farrington, CPaddy The Lancet, Vol. 353, Issue 9169 https://doi.org/10.1016/S0140-6736(99)01239-8	journal	June 1999
The role of mobile phone-based interventions to improve routine childhood immunisation coverage Kazi, Abdul Momin The Lancet Global Health, Vol. 5, Issue 4 https://doi.org/10.1016/S2214-109X(17)30088-8	journal	April 2017
Seven pillars of precision digital health and medicine Shaban-Nejad, Arash; Michalowski, Martin; Peek, Niels Artificial Intelligence in Medicine, Vol. 103 https://doi.org/10.1016/j.artmed.2020.101793	journal	March 2020
COVID-19 pathophysiology: A review Yuki, Koichi; Fujiogi, Miho; Koutsogiannaki, Sophia Clinical Immunology, Vol. 215 https://doi.org/10.1016/j.clim.2020.108427	journal	June 2020
Combating vaccine hesitancy and other 21st century social determinants in the global fight against measles Hotez, Peter J.; Nuzhath, Tasmiah; Colwell, Brian Current Opinion in Virology, Vol. 41 https://doi.org/10.1016/j.coviro.2020.01.001	journal	April 2020
Getting Human Papillomavirus Vaccination Back on Track: Protecting Our National Investment in Human Papillomavirus Vaccination in the COVID-19 Era Gilkey, Melissa B.; Bednarczyk, Robert A.; Gerend, Mary A. Journal of Adolescent Health, Vol. 67, Issue 5 https://doi.org/10.1016/j.jadohealth.2020.08.013	journal	November 2020
Potential immuno-nanomedicine strategies to fight COVID-19 like pulmonary infections Bonam, Srinivasa Reddy; Kotla, Niranjan G.; Bohara, Raghvendra A. Nano Today, Vol. 36 https://doi.org/10.1016/j.nantod.2020.101051	journal	February 2021
Parental decline of pneumococcal vaccination and risk of pneumococcal related disease in children Glanz, Jason M.; McClure, David L.; O’Leary, Sean T. Vaccine, Vol. 29, Issue 5 https://doi.org/10.1016/j.vaccine.2010.11.085	journal	January 2011
Next-generation vaccine platforms for COVID-19 van Riel, Debby; de Wit, Emmie Nature Materials, Vol. 19, Issue 8 https://doi.org/10.1038/s41563-020-0746-0	journal	July 2020
Health intelligence: how artificial intelligence transforms population and personalized health Shaban-Nejad, Arash; Michalowski, Martin; Buckeridge, David L. npj Digital Medicine, Vol. 1, Issue 1 https://doi.org/10.1038/s41746-018-0058-9	journal	October 2018
A Population-Based Study of Measles, Mumps, and Rubella Vaccination and Autism Madsen, Kreesten Meldgaard; Hviid, Anders; Vestergaard, Mogens New England Journal of Medicine, Vol. 347, Issue 19 https://doi.org/10.1056/NEJMoa021134	journal	November 2002
How health care providers should address vaccine hesitancy in the clinical setting: Evidence for presumptive language in making a strong recommendation Jacobson, Robert M.; St. Sauver, Jennifer L.; Griffin, Joan M. Human Vaccines & Immunotherapeutics, Vol. 16, Issue 9 https://doi.org/10.1080/21645515.2020.1735226	journal	April 2020
Trends in Kindergarten Rates of Vaccine Exemption and State-Level Policy, 2011–2016 Omer, Saad B.; Porter, Rachael M.; Allen, Kristen Open Forum Infectious Diseases, Vol. 5, Issue 2 https://doi.org/10.1093/ofid/ofx244	journal	November 2017
Coaching primary care clinics for HPV vaccination quality improvement: Comparing in-person and webinar implementation Calo, William A.; Gilkey, Melissa B.; Leeman, Jennifer Translational Behavioral Medicine, Vol. 9, Issue 1 https://doi.org/10.1093/tbm/iby008	journal	February 2018
The growing epidemic of sexually transmitted infections in adolescents: a neglected population Shannon, Chelsea L.; Klausner, Jeffrey D. Current Opinion in Pediatrics, Vol. 30, Issue 1 https://doi.org/10.1097/MOP.0000000000000578	journal	January 2018
Decline in child vaccination coverage during the COVID‐19 pandemic — Michigan Care Improvement Registry, May 2016‐May 2020 Bramer, Cristi A.; Kimmins, Lynsey M.; Swanson, Robert American Journal of Transplantation, Vol. 20, Issue 7 https://doi.org/10.1111/ajt.16112	journal	June 2020
Routine vaccination during covid-19 pandemic response Saxena, Sonia; Skirrow, Helen; Bedford, Helen BMJ https://doi.org/10.1136/bmj.m2392	journal	June 2020
Vaccine attitude surveillance using semantic analysis: constructing a semantically annotated corpus Brien, Stephanie; Naderi, Nona; Shaban-Nejad, Arash Proceedings of the 22nd International Conference on World Wide Web - WWW '13 Companion https://doi.org/10.1145/2487788.2488023	conference	January 2013
Increasing Vaccination: Putting Psychological Science Into Action Brewer, Noel T.; Chapman, Gretchen B.; Rothman, Alexander J. Psychological Science in the Public Interest, Vol. 18, Issue 3 https://doi.org/10.1177/1529100618760521	journal	December 2017
The state of the antivaccine movement in the United States: A focused examination of nonmedical exemptions in states and counties Olive, Jacqueline K.; Hotez, Peter J.; Damania, Ashish PLOS Medicine, Vol. 15, Issue 6 https://doi.org/10.1371/journal.pmed.1002578	journal	June 2018
Mandatory Vaccination in Europe Vaz, Olivia M.; Ellingson, Mallory K.; Weiss, Paul Pediatrics, Vol. 145, Issue 2 https://doi.org/10.1542/peds.2019-0620	journal	January 2020
Measles Outbreak — Minnesota April–May 2017 Hall, Victoria; Banerjee, Emily; Kenyon, Cynthia MMWR. Morbidity and Mortality Weekly Report, Vol. 66, Issue 27 https://doi.org/10.15585/mmwr.mm6627a1	journal	July 2017
Notes from the Field: Measles Outbreaks from Imported Cases in Orthodox Jewish Communities — New York and New Jersey, 2018–2019 McDonald, Robert; Ruppert, Patricia Schnabel; Souto, Maria MMWR. Morbidity and Mortality Weekly Report, Vol. 68, Issue 19 https://doi.org/10.15585/mmwr.mm6819a4	journal	May 2019
National, Regional, State, and Selected Local Area Vaccination Coverage Among Adolescents Aged 13–17 Years — United States, 2018 Walker, Tanja Y.; Elam-Evans, Laurie D.; Yankey, David MMWR. Morbidity and Mortality Weekly Report, Vol. 68, Issue 33 https://doi.org/10.15585/mmwr.mm6833a2	journal	August 2019
Effects of the COVID-19 Pandemic on Routine Pediatric Vaccine Ordering and Administration — United States, 2020 Santoli, Jeanne M.; Lindley, Megan C.; DeSilva, Malini B. MMWR. Morbidity and Mortality Weekly Report, Vol. 69, Issue 19 https://doi.org/10.15585/mmwr.mm6919e2	journal	May 2020
National, Regional, State, and Selected Local Area Vaccination Coverage Among Adolescents Aged 13–17 Years — United States, 2019 Elam-Evans, Laurie D.; Yankey, David; Singleton, James A. MMWR. Morbidity and Mortality Weekly Report, Vol. 69, Issue 33 https://doi.org/10.15585/mmwr.mm6933a1	journal	August 2020
Vaccination Coverage with Selected Vaccines and Exemption Rates Among Children in Kindergarten — United States, 2019–20 School Year Seither, Ranee; McGill, Michael T.; Kriss, Jennifer L. MMWR. Morbidity and Mortality Weekly Report, Vol. 70, Issue 3 https://doi.org/10.15585/mmwr.mm7003a2	journal	January 2021
Vaccine Safety: Myths and Misinformation Geoghegan, Sarah; O’Callaghan, Kevin P.; Offit, Paul A. Frontiers in Microbiology, Vol. 11 https://doi.org/10.3389/fmicb.2020.00372	journal	March 2020
The effect of social determinants on immunization programs Glatman-Freedman, Aharona; Nichols, Katherine Human Vaccines & Immunotherapeutics, Vol. 8, Issue 3 https://doi.org/10.4161/hv.19003	journal	March 2012
Lessons learned and applied: What the 20th century vaccine experience can teach us about vaccines in the 21st century Hebert, Corey Joseph; Hall, Corey M.; Odoms, La’ Nyia J. Human Vaccines & Immunotherapeutics, Vol. 8, Issue 5 https://doi.org/10.4161/hv.19204	journal	May 2012
MMR, Wakefield and The Lancet: what can we learn? Leask, Julie; Booy, Robert; McIntyre, Peter B. Medical Journal of Australia, Vol. 193, Issue 1 https://doi.org/10.5694/j.1326-5377.2010.tb03730.x	journal	July 2010

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Addressing Parental Vaccine Hesitancy and Other Barriers to Childhood/Adolescent Vaccination Uptake During the Coronavirus (COVID-19) Pandemic

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