Reduced meiotic recombination in rhesus macaques and the origin of the human recombination landscape

Xue, Cheng; Rustagi, Navin; Liu, Xiaoming; Raveendran, Muthuswamy; Harris, R. Alan; Venkata, Manjunath Gorentla; Rogers, Jeffrey; Yu, Fuli

doi:10.1371/journal.pone.0236285

Reduced meiotic recombination in rhesus macaques and the origin of the human recombination landscape

Journal Article · Tue Aug 25 00:00:00 EDT 2020 · PLoS ONE

DOI:https://doi.org/10.1371/journal.pone.0236285· OSTI ID:1815887

^[1]; Rustagi, Navin ^[2]; ^[3]; Raveendran, Muthuswamy ^[2]; ^[2]; Venkata, Manjunath Gorentla ^[4]; Rogers, Jeffrey ^[2]; Yu, Fuli ^[2]

Baylor Univ., Houston, TX (United States). College of Medicine. Dept. of Molecular and Human Genetics. Human Genome Sequencing Center; OSTI
Baylor Univ., Houston, TX (United States). College of Medicine. Dept. of Molecular and Human Genetics. Human Genome Sequencing Center
Univ. of South Florida, Tampa, FL (United States). USF Genomics & College of Public Health
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Characterizing meiotic recombination rates across the genomes of nonhuman primates is important for understanding the genetics of primate populations, performing genetic analyses of phenotypic variation and reconstructing the evolution of human recombination. Rhesus macaques (Macaca mulatta) are the most widely used nonhuman primates in biomedical research. We constructed a high-resolution genetic map of the rhesus genome based on whole genome sequence data from Indian-origin rhesus macaques. The genetic markers used were approximately 18 million SNPs, with marker density 6.93 per kb across the autosomes. We report that the genome-wide recombination rate in rhesus macaques is significantly lower than rates observed in apes or humans, while the distribution of recombination across the macaque genome is more uniform. These observations provide new comparative information regarding the evolution of recombination in primates.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1815887

Journal Information:: PLoS ONE, Journal Name: PLoS ONE Journal Issue: 8 Vol. 15; ISSN 1932-6203

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

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