Mapping Influenza-Induced Posttranslational Modifications on Histones from CD8+ T Cells

Rezinciuc, Svetlana; Tian, Zhixin; Wu, Si; Hengel, Shawna; Pasa-Tolic, Ljiljana; Smallwood, Heather S.

doi:10.3390/v12121409

Mapping Influenza-Induced Posttranslational Modifications on Histones from CD8+ T Cells

Journal Article · Tue Dec 08 04:00:00 EST 2020 · Viruses

DOI:https://doi.org/10.3390/v12121409· OSTI ID:1815693

Rezinciuc, Svetlana ^[1]; Tian, Zhixin ^[2]; Wu, Si ^[2]; Hengel, Shawna ^[2]; Pasa-Tolic, Ljiljana ^[2]; ^[3]

Univ. of Tennessee Health Science Center, Memphis, TN (United States). Dept. of Pediatrics; OSTI
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab.
Univ. of Tennessee Health Science Center, Memphis, TN (United States). Dept. of Pediatrics; Children’s Foundation Research Inst., Memphis, TN (United States)

T cell function is determined by transcriptional networks that are regulated by epigenetic programming via posttranslational modifications (PTMs) to histone proteins and DNA. Bottom-up mass spectrometry (MS) can identify histone PTMs, whereas intact protein analysis by MS can detect species missed by bottom-up approaches. We used a novel approach of online two-dimensional liquid chromatography-tandem MS with high-resolution reversed-phase liquid chromatography (RPLC), alternating electron transfer dissociation (ETD) and collision-induced dissociation (CID) on precursor ions to maximize fragmentation of uniquely modified species. The first online RPLC separation sorted histone families, then RPLC or weak cation exchange hydrophilic interaction liquid chromatography (WCX-HILIC) separated species heavily clad in PTMs. Tentative identifications were assigned by matching proteoform masses to predicted theoretical masses that were verified with tandem MS. We used this innovative approach for histone-intact protein PTM mapping (HiPTMap) to identify and quantify proteoforms purified from CD8 T cells after in vivo influenza infection. Activation significantly altered PTMs following influenza infection, histone maps changed as T cells migrated to the site of infection, and T cells responding to secondary infections had significantly more transcription enhancing modifications. Thus, HiPTMap identified and quantified proteoforms and determined changes in CD8 T cell histone PTMs over the course of infection.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1815693

Journal Information:: Viruses, Journal Name: Viruses Journal Issue: 12 Vol. 12; ISSN 1999-4915

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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