Unlocking the secrets of the genome

Celniker, Susan E.; Dillon, Laura A.  L.; Gerstein, Mark B.; Gunsalus, Kristin C.; Henikoff, Steven; Karpen, Gary H.; Kellis, Manolis; Lai, Eric C.; Lieb, Jason D.; MacAlpine, David M.; Micklem, Gos; Piano, Fabio; Snyder, Michael; Stein, Lincoln; White, Kevin P.; Waterston, Robert H.

doi:10.1038/459927a

Unlocking the secrets of the genome

Journal Article · Wed Jun 17 00:00:00 EDT 2009 · Nature (London)

DOI:https://doi.org/10.1038/459927a· OSTI ID:1815440

Celniker, Susan E. ^[1]; Dillon, Laura A. L. ^[2]; Gerstein, Mark B. ^[3]; Gunsalus, Kristin C. ^[4]; Henikoff, Steven ^[5]; Karpen, Gary H. ^[6]; Kellis, Manolis ^[7]; Lai, Eric C. ^[8]; Lieb, Jason D. ^[9]; MacAlpine, David M. ^[10]; Micklem, Gos ^[11]; Piano, Fabio ^[4]; Snyder, Michael ^[12]; Stein, Lincoln ^[13]; White, Kevin P. ^[14]; Waterston, Robert H. ^[15]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Dept. of Genome Biology; OSTI
National Institutes of Health (NIH), Bethesda, MD (United States). National Human Genome Research Inst. Division of Extramural Research
Yale Univ., New Haven, CT (United States). Program in Computational Biology and Bioinformatics; Yale Univ., New Haven, CT (United States). Dept. of Computer Scienc. Dept. of Molecular Biophysics and Biochemistry
New York Univ. (NYU), NY (United States). Center for Genomics and Systems Biology
Fred Hutchinson Cancer Research Center, Seattle, WA (United States). Basic Sciences Division
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Dept. of Genome and Computational Biology
Broad Inst. of Massachusetts Institute of Technology and Harvard University, Cambridge, MA (United States); Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Computer Science and Artificial Intelligence Lab.
Sloan-Kettering Inst., New York, NY (United States)
Univ. of North Carolina, Chapel Hill, NC (United States). Carolina Center for Genome Sciences. Dept. of Biology
Duke Univ., Durham, NC (United States). Medical Center. Dept. of Pharmacology and Cancer Biology
Univ. of Cambridge (United Kingdom). Cambridge Systems Biology Centre. Dept. of Genetics
Yale Univ., New Haven, CT (United States). Dept. of Molecular, Cellular and Developmental Biology
Cold Spring Harbor Lab., Cold Spring Harbor, NY (United States)
Univ. of Chicago, IL (United States). Inst. for Genomics & Systems Biology; Argonne National Lab. (ANL), Argonne, IL (United States). Inst. for Genomics & Systems Biology
Univ. of Washington, Seattle, WA (United States). Dept. of Genome Sciences

The primary objective of the Human Genome Project was to produce high-quality sequences not just for the human genome but also for those of the chief model organisms: Escherichia coli, yeast (Saccharomyces cerevisiae), worm (Caenorhabditis elegans), fly (Drosophila melanogaster) and mouse (Mus musculus). Free access to the resultant data has prompted much biological research, including development of a map of common human genetic variants (the International HapMap Project), expression profiling of healthy and diseased cells and in-depth studies of many individual genes. These genome sequences have enabled researchers to carry out genetic and functional genomic studies not previously possible, revealing new biological insights with broad relevance across the animal kingdom.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Contributing Organization:: modENCODE Consortium

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1815440

Journal Information:: Nature (London), Journal Name: Nature (London) Journal Issue: 7249 Vol. 459; ISSN 0028-0836

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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The Complex Contributions of Genetics and Nutrition to Immunity in Drosophila melanogaster Unckless, Robert L.; Rottschaefer, Susan M.; Lazzaro, Brian P. PLOS Genetics, Vol. 11, Issue 3 https://doi.org/10.1371/journal.pgen.1005030	journal	March 2015
The Landscape of A-to-I RNA Editome Is Shaped by Both Positive and Purifying Selection Yu, Yao; Zhou, Hongxia; Kong, Yimeng PLOS Genetics, Vol. 12, Issue 7 https://doi.org/10.1371/journal.pgen.1006191	journal	July 2016
Dynamic genome wide expression profiling of Drosophila head development reveals a novel role of Hunchback in retinal glia cell development and blood-brain barrier integrity Torres-Oliva, Montserrat; Schneider, Julia; Wiegleb, Gordon PLOS Genetics, Vol. 14, Issue 1 https://doi.org/10.1371/journal.pgen.1007180	journal	January 2018
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Heme peroxidase HPX-2 protects Caenorhabditis elegans from pathogens Liu, Yi; Kaval, Karan Gautam; van Hoof, Ambro PLOS Genetics, Vol. 15, Issue 1 https://doi.org/10.1371/journal.pgen.1007944	journal	January 2019
Sperm-Leucylaminopeptidases are required for male fertility as structural components of mitochondrial paracrystalline material in Drosophila melanogaster sperm Laurinyecz, Barbara; Vedelek, Viktor; Kovács, Attila L. PLOS Genetics, Vol. 15, Issue 2 https://doi.org/10.1371/journal.pgen.1007987	journal	February 2019
Gene Expression of the Tumour Suppressor LKB1 Is Mediated by Sp1, NF-Y and FOXO Transcription Factors Lützner, Nicolas; De-Castro Arce, Johanna; Rösl, Frank PLoS ONE, Vol. 7, Issue 3 https://doi.org/10.1371/journal.pone.0032590	journal	March 2012
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The Genetic Architecture of Degenerin/Epithelial Sodium Channels in Drosophila Zelle, Kathleen M.; Lu, Beika; Pyfrom, Sarah C. G3 Genes\|Genomes\|Genetics, Vol. 3, Issue 3 https://doi.org/10.1534/g3.112.005272	journal	March 2013
Gene Model Annotations for Drosophila melanogaster : Impact of High-Throughput Data Matthews, Beverley B.; dos Santos, Gilberto; Crosby, Madeline A. G3: Genes\|Genomes\|Genetics, Vol. 5, Issue 8 https://doi.org/10.1534/g3.115.018929	journal	June 2015
flyDIVaS : A Comparative Genomics Resource for Drosophila Divergence and Selection Stanley, Craig E.; Kulathinal, Rob J. G3: Genes\|Genomes\|Genetics, Vol. 6, Issue 8 https://doi.org/10.1534/g3.116.031138	journal	May 2016
An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock Agrawal, Parul; Hardin, Paul E. G3 Genes\|Genomes\|Genetics, Vol. 6, Issue 12 https://doi.org/10.1534/g3.116.035345	journal	December 2016
Genome-Wide Association Analysis of Anoxia Tolerance in Drosophila melanogaster Campbell, Jacob B.; Overby, Paula F.; Gray, Alyx E. G3 Genes\|Genomes\|Genetics, Vol. 9, Issue 9 https://doi.org/10.1534/g3.119.400421	journal	September 2019
Genetics on the Fly: A Primer on the Drosophila Model System Hales, Karen G.; Korey, Christopher A.; Larracuente, Amanda M. Genetics, Vol. 201, Issue 3 https://doi.org/10.1534/genetics.115.183392	journal	November 2015
Epidermal Remodeling in Caenorhabditis elegans Dauers Requires the Nidogen Domain Protein DEX-1 Flatt, Kristen M.; Beshers, Caroline; Unal, Cagla Genetics, Vol. 211, Issue 1 https://doi.org/10.1534/genetics.118.301557	journal	November 2018
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Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents Cowell, Ian G.; Austin, Caroline A. International Journal of Environmental Research and Public Health, Vol. 9, Issue 6 https://doi.org/10.3390/ijerph9062075	journal	May 2012
The First 50 Plant Genomes Michael, Todd P.; Jackson, Scott The Plant Genome, Vol. 6, Issue 2 https://doi.org/10.3835/plantgenome2013.03.0001in	journal	July 2013
Transcription termination between polo and snap, two closely spaced tandem genes of D. melanogaster Henriques, Telmo; Ji, Zhe; Tan-Wong, Sue Mei Transcription, Vol. 3, Issue 4 https://doi.org/10.4161/trns.21967	journal	July 2012
Analysis of C. elegans intestinal gene expression and polyadenylation by fluorescence-activated nuclei sorting and 3'-end-seq Haenni, Simon; Ji, Zhe; Hoque, Mainul Oxford University Press https://doi.org/10.5167/uzh-61843	text	January 2012
Conservation of transcription factor binding specificities across 600 million years of bilateria evolution Nitta, Kazuhiro R.; Jolma, Arttu; Yin, Yimeng eLife, Vol. 4 https://doi.org/10.7554/elife.04837	journal	March 2015
Establishment and maintenance of heritable chromatin structure during early Drosophila embryogenesis Blythe, Shelby A.; Wieschaus, Eric F. eLife, Vol. 5 https://doi.org/10.7554/elife.20148	journal	November 2016
Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells Viswanatha, Raghuvir; Li, Zhongchi; Hu, Yanhui eLife, Vol. 7 https://doi.org/10.7554/elife.36333	journal	July 2018

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