Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles

Hymel, David; Tsuji, Kohei; Grant, Robert A.; Chingle, Ramesh M.; Kunciw, Dominique L.; Yaffe, Michael B.; Burke, Terrence R.

doi:10.1039/D1OB01120K

Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles

Journal Article · Wed Sep 22 00:00:00 EDT 2021 · Organic and Biomolecular Chemistry

DOI:https://doi.org/10.1039/D1OB01120K· OSTI ID:1811945

Hymel, David ^[1]; ^[1]; ^[2]; Chingle, Ramesh M. ^[1]; Kunciw, Dominique L. ^[1]; ^[2]; ^[1]

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
Department of Biology and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA

A novel macrocyclic peptide strategy utilizing a glutamic acid analog that can work as an alkylated histidine replacement.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1811945

Alternate ID(s):: OSTI ID: 1879684
OSTI ID: 1900708

Journal Information:: Organic and Biomolecular Chemistry, Journal Name: Organic and Biomolecular Chemistry Journal Issue: 36 Vol. 19; ISSN OBCRAK; ISSN 1477-0520

Publisher:: Royal Society of Chemistry (RSC)Copyright Statement

Country of Publication:: United Kingdom

Language:: English

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Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

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Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocycles

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