Long-Term Effects of Very Low Dose Particle Radiation on Gene Expression in the Heart: Degenerative Disease Risks

Garikipati, Venkata Srikanth; Arakelyan, Arsen; Blakely, Eleanor A.; Chang, Polly Y.; Truongcao, May M.; Cimini, Maria; Malaredy, Vandana; Bajpai, Anamika; Addya, Sankar; Bisserier, Malik; Brojakowska, Agnieszka; Eskandari, Abrisham; Khlgatian, Mary K.; Hadri, Lahouaria; Fish, Kenneth M.; Kishore, Raj; Goukassian, David. A.

doi:10.3390/cells10020387

Long-Term Effects of Very Low Dose Particle Radiation on Gene Expression in the Heart: Degenerative Disease Risks

Journal Article · Sat Feb 13 04:00:00 EST 2021 · Cells

DOI:https://doi.org/10.3390/cells10020387· OSTI ID:1807569

Garikipati, Venkata Srikanth ^[1]; ^[2]; Blakely, Eleanor A. ^[3]; Chang, Polly Y. ^[4]; Truongcao, May M. ^[5]; Cimini, Maria ^[5]; Malaredy, Vandana ^[5]; Bajpai, Anamika ^[5]; Addya, Sankar ^[6]; ^[7]; ^[7]; ^[7]; Khlgatian, Mary K. ^[7]; Hadri, Lahouaria ^[7]; Fish, Kenneth M. ^[7]; ^[5]; Goukassian, David. A. ^[7]

The Ohio State Univ., Columbus, OH (United States)
PathVerse, Yerevan (Armenia); The National Academy of Sciences of the Republic of Armenia, Yerevan (Armenia)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
SRI International, Menlo Park, CA (United States)
Temple Univ., Philadelphia, PA (United States)
Thomas Jefferson Univ., Philladelphia, PA (United States)
Icahn School of Medicine at Mount Sinai, New York, NY (United States)

Compared to low doses of gamma irradiation (γ-IR), high-charge-and-energy (HZE) particle IR may have different biological response thresholds in cardiac tissue at lower doses, and these effects may be IR type and dose dependent. Three- to four-month-old female CB6F1/Hsd mice were exposed once to one of four different doses of the following types of radiation: γ-IR 137Cs (40-160 cGy, 0.662 MeV), 14Si-IR (4-32 cGy, 260 MeV/n), or 22Ti-IR (3-26 cGy, 1 GeV/n). At 16 months post-exposure, animals were sacrificed and hearts were harvested and archived as part of the NASA Space Radiation Tissue Sharing Forum. These heart tissue samples were used in our study for RNA isolation and microarray hybridization. Functional annotation of twofold up/down differentially expressed genes (DEGs) and bioinformatics analyses revealed the following: (i) there were no clear lower IR thresholds for HZE- or γ-IR; (ii) there were 12 common DEGs across all 3 IR types; (iii) these 12 overlapping genes predicted various degrees of cardiovascular, pulmonary, and metabolic diseases, cancer, and aging; and (iv) these 12 genes revealed an exclusive non-linear DEG pattern in 14Si- and 22Ti-IR-exposed hearts, whereas two-thirds of γ-IR-exposed hearts revealed a linear pattern of DEGs. Thus, our study may provide experimental evidence of excess relative risk (ERR) quantification of low/very low doses of full-body space-type IR-associated degenerative disease development.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

OSTI ID:: 1807569

Alternate ID(s):: OSTI ID: 1810752

Journal Information:: Cells, Journal Name: Cells Journal Issue: 2 Vol. 10; ISSN 2073-4409

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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