Synthesis, antibiotic structure–activity relationships, and cellulose dissolution studies of new room-temperature ionic liquids derived from lignin

Liu, Shihong; Gonzalez, Michael; Kong, Celine; Weir, Scott; Socha, Aaron M.

doi:10.1186/s13068-021-01898-x

Title: Synthesis, antibiotic structure–activity relationships, and cellulose dissolution studies of new room-temperature ionic liquids derived from lignin

Journal Article · Tue Feb 23 00:00:00 EST 2021 · Biotechnology for Biofuels

DOI:https://doi.org/10.1186/s13068-021-01898-x· OSTI ID:1808520

Liu, Shihong ^[1]; Gonzalez, Michael ^[2]; Kong, Celine ^[2]; Weir, Scott ^[2];

^[1]

Queens Univ. of Charlotte, NC (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Queens Univ. of Charlotte, NC (United States)

Ionic liquids (ILs) are promising pretreatment solvents for lignocellulosic biomass, but are largely prepared from petroleum precursors. Benzaldehydes from depolymerized lignin, such as vanillin, syringaldehyde, and 4-methoxy benzaldehyde, represent renewable feedstocks for the synthesis of ionic liquids. We herein report syntheses of novel lignin-derived ionic liquids, with extended N-alkyl chains, and examine their melting points, cellulose dissolution capacities, and toxicity profiles against Daphnia magna and E. coli strain 1A1. The latter organism has been engineered to produce isoprenol, a drop-in biofuel and precursor for commodity chemicals. The new N,N-diethyl and N,N-dipropyl methyl benzylammonium ILs were liquids at room temperature, showing 75–100 °C decreased melting points as compared to their N,N,N-trimethyl benzylammonium analog. Extension of N-alkyl chains also increased antibacterial activity threefold, while ionic liquids prepared from vanillin showed 2- to 4-fold lower toxicity as compared to those prepared from syringaldehyde and 4-methoxybenzaldehyde. The trend of antibacterial activity for anions of lignin-derived ILs was found to be methanesulfonate < acetate < hydroxide. Microcrystalline cellulose dissolution, from 2 to 4 wt% after 20 min at 100 °C, was observed in all new ILs using light microscopy and IR spectroscopy. Ionic liquids prepared from H-, S- and G-lignin oxidation products provided differential cytotoxic activity against E. coli and D. magna, suggesting these compounds could be tailored for application specificity within a biorefinery.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE), Energy Efficiency Office. Building Technologies Office; National Science Foundation (NSF)

Grant/Contract Number:: AC02-05CH11231; 1601636

OSTI ID:: 1808520

Journal Information:: Biotechnology for Biofuels, Vol. 14, Issue 1; ISSN 1754-6834

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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Additional file 1 of Synthesis, antibiotic structure–activity relationships, and cellulose dissolution studies of new room-temperature ionic liquids derived from lignin Liu, Shihong; Gonzalez, Michael; Kong, Celine https://doi.org/10.6084/m9.figshare.14100610 The current record is supplemented by this text	text	January 2021
Synthesis, antibiotic structure–activity relationships, and cellulose dissolution studies of new room-temperature ionic liquids derived from lignin Liu, Shihong; Gonzalez, Michael; Kong, Celine https://doi.org/10.6084/m9.figshare.c.5316187.v1 The current record is supplemented by this collection	collection	January 2021
Synthesis, antibiotic structure–activity relationships, and cellulose dissolution studies of new room-temperature ionic liquids derived from lignin Liu, Shihong; Gonzalez, Michael; Kong, Celine https://doi.org/10.6084/m9.figshare.c.5316187 The current record is supplemented by this collection	collection	January 2021
Additional file 1 of Synthesis, antibiotic structure–activity relationships, and cellulose dissolution studies of new room-temperature ionic liquids derived from lignin Liu, Shihong; Gonzalez, Michael; Kong, Celine https://doi.org/10.6084/m9.figshare.14100610.v1 The current record is supplemented by this text	text	January 2021

Title: Synthesis, antibiotic structure–activity relationships, and cellulose dissolution studies of new room-temperature ionic liquids derived from lignin

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