Stepping on the Gas to a Circular Economy: Accelerating Development of Carbon-Negative Chemical Production from Gas Fermentation

Fackler, Nick; Heijstra, Björn D.; Rasor, Blake J.; Brown, Hunter; Martin, Jacob; Ni, Zhuofu; Shebek, Kevin M.; Rosin, Rick R.; Simpson, Séan D.; Tyo, Keith E.; Giannone, Richard J.; Hettich, Robert L.; Tschaplinski, Timothy J.; Leang, Ching; Brown, Steven D.; Jewett, Michael C.; Köpke, Michael

doi:10.1146/annurev-chembioeng-120120-021122

Stepping on the Gas to a Circular Economy: Accelerating Development of Carbon-Negative Chemical Production from Gas Fermentation

Journal Article · Mon Apr 19 00:00:00 EDT 2021 · Annual Review of Chemical and Biomolecular Engineering

DOI:https://doi.org/10.1146/annurev-chembioeng-120120-021122· OSTI ID:1807218

Fackler, Nick ^[1]; Heijstra, Björn D. ^[1]; Rasor, Blake J. ^[2]; Brown, Hunter ^[2]; Martin, Jacob ^[2]; Ni, Zhuofu ^[2]; Shebek, Kevin M. ^[2]; Rosin, Rick R. ^[1]; Simpson, Séan D. ^[1]; Tyo, Keith E. ^[2]; Giannone, Richard J. ^[3]; Hettich, Robert L. ^[3]; Tschaplinski, Timothy J. ^[3]; Leang, Ching ^[1]; Brown, Steven D. ^[1]; Jewett, Michael C. ^[2]; Köpke, Michael ^[1]

LanzaTech Inc., Skokie, IL (United States)
Northwestern Univ., Evanston, IL (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Owing to rising levels of greenhouse gases in our atmosphere and oceans, climate change poses significant environmental, economic, and social challenges globally. Technologies that enable carbon capture and conversion of greenhouse gases into useful products will help mitigate climate change by enabling a new circular carbon economy. Gas fermentation using carbon-fixing microorganisms offers an economically viable and scalable solution with unique feedstock and product flexibility that has been commercialized recently. Here, we review the state of the art of gas fermentation and discuss opportunities to accelerate future development and rollout. We discuss the current commercial process for conversion of waste gases to ethanol, including the underlying biology, challenges in process scale-up, and progress on genetic tool development and metabolic engineering to expand the product spectrum. We emphasize key enabling technologies to accelerate strain development for acetogens and other nonmodel organisms.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); USDOE Office of Energy Efficiency and Renewable Energy (EERE)

Grant/Contract Number:: AC05-00OR22725; SC0018249

OSTI ID:: 1807218

Journal Information:: Annual Review of Chemical and Biomolecular Engineering, Journal Name: Annual Review of Chemical and Biomolecular Engineering Journal Issue: 1 Vol. 12; ISSN 1947-5438

Publisher:: Annual ReviewsCopyright Statement

Country of Publication:: United States

Language:: English

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