Fluorescent detection of cholesterol using p-Sulfonatocalix[4]arene functionalized carbon nanotubes and thermally reduced graphite oxide composites

Aryal, Krishna Prasad; Ekanayaka, Thilini K.; Gilbert, Simeon; Dowben, Peter A.; Jeong, Hae Kyung

doi:10.1016/j.cplett.2019.136856

Title: Fluorescent detection of cholesterol using p-Sulfonatocalix[4]arene functionalized carbon nanotubes and thermally reduced graphite oxide composites

Journal Article · Fri Oct 11 00:00:00 EDT 2019 · Chemical Physics Letters

DOI:https://doi.org/10.1016/j.cplett.2019.136856· OSTI ID:1800396

Aryal, Krishna Prasad ^[1]; Ekanayaka, Thilini K. ^[2]; Gilbert, Simeon ^[2]; Dowben, Peter A. ^[2];

^[1]

Daegu Univ., Gyeongsan (Korea, Republic of)
Univ. of Nebraska, Lincoln, NE (United States)

In the present study, carbon nanotube (CNT), thermally reduced graphite oxide (TRGO), and CNT-TRGO were functionalized with p-sulfonatocalix[4]arene (SC4) and then investigated for fluorescent detection of cholesterol in the presence of rhodamine 6G (R6G). All of the composite samples show effective quenching of R6G fluorescent intensity without cholesterol, but the fluorescence intensity significantly increases with the addition of cholesterol. The results indicate a strong interaction between SC4 composites and cholesterol rather than between the SC4 composites and R6G, increasing R6G fluorescence intensity in the presence of cholesterol due to the release of R6G from the SC4 composites. Formation of the complex, made of the SC4 composite plus the cholesterol, enables the detection of cholesterol in the wide range of cholesterol concentration up to 109 µM. The binding constant between SC4 and cholesterol has been calculated, indicating that the SC4 composites display the maximum binding constant of 1.9 × 10⁴ M^-1 with cholesterol.

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Research Organization:: Univ. of Central Florida, Orlando, FL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: FG02-07ER15842

OSTI ID:: 1800396

Alternate ID(s):: OSTI ID: 1659332

Journal Information:: Chemical Physics Letters, Vol. 738; ISSN 0009-2614

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 4 works

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References (18)

Biopharmaceutical applications of calixarenes Da Silva, E.; Lazar, A. N.; Coleman, A. W. Journal of Drug Delivery Science and Technology, Vol. 14, Issue 1 https://doi.org/10.1016/S1773-2247(04)50001-1	journal	January 2004
Fluorescent cholesterol sensing using enzyme-modified CdSe/ZnS quantum dots Kim, Ki-Eun; Kim, Tae Geun; Sung, Yun-Mo Journal of Nanoparticle Research, Vol. 14, Issue 10 https://doi.org/10.1007/s11051-012-1179-8	journal	September 2012
Functionalization of thermally reduced graphite oxide and carbon nanotubes by p-sulfonatocalix[4]arene and supramolecular recognition of tyrosine Aryal, Krishna Prasad; Jeong, Hae Kyung Chemical Physics Letters, Vol. 714 https://doi.org/10.1016/j.cplett.2018.10.074	journal	January 2019
Calixarene-functionalized graphene oxide composites fixed on glassy carbon electrodes for electrochemical detection Zhang, Peng; Wang, Yaling; Zhang, Dongxiang RSC Advances, Vol. 6, Issue 94 https://doi.org/10.1039/C6RA19674H	journal	January 2016
Evidence of Graphitic AB Stacking Order of Graphite Oxides Jeong, Hae-Kyung; Lee, Yun Pyo; Lahaye, Rob J. W. E. Journal of the American Chemical Society, Vol. 130, Issue 4 https://doi.org/10.1021/ja076473o	journal	January 2008
Comparison of Binding Affinities of Water-Soluble Calixarenes with the Organophosphorus Nerve Agent Soman (GD) and Commonly-Used Nerve Agent Simulants Ede, Jayne; Cragg, Peter; Sambrook, Mark Molecules, Vol. 23, Issue 1 https://doi.org/10.3390/molecules23010207	journal	January 2018
Comparison of interfacial behavior and silver extraction kinetics with various types calix[4]arene derivatives at heterogeneous liquid-liquid interfaces Kim, Jee Young; Morisada, Shintaro; Kawakita, Hidetaka Journal of Chromatography A, Vol. 1558 https://doi.org/10.1016/j.chroma.2018.04.013	journal	July 2018
Calix[4,6,8]arenesulfonates Functionalized Reduced Graphene Oxide with High Supramolecular Recognition Capability: Fabrication and Application for Enhanced Host–Guest Electrochemical Recognition Zhou, Jun; Chen, Ming; Diao, Guowang ACS Applied Materials & Interfaces, Vol. 5, Issue 3 https://doi.org/10.1021/am302289v	journal	January 2013
Polarographic method for rapid microdetermination of cholesterol with cholesterol esterase and cholesterol oxidase. Noma, A.; Nakayama, K. Clinical Chemistry, Vol. 22, Issue 3 https://doi.org/10.1093/clinchem/22.3.336	journal	March 1976
Voltammetric Sensor for Total Cholesterol Determination Derina, Ksenia V.; Korotkova, Elena I.; Dorozhko, Elena V. Procedia Chemistry, Vol. 10 https://doi.org/10.1016/j.proche.2014.10.087	journal	January 2014
A carbon dot–hemoglobin complex-based biosensor for cholesterol detection Bui, Trang Thi; Park, Soo-Young Green Chemistry, Vol. 18, Issue 15 https://doi.org/10.1039/C6GC00507A	journal	January 2016
Fluorescent detection of cholesterol using β-cyclodextrin functionalized graphene Mondal, Avijit; Jana, Nikhil R. Chemical Communications, Vol. 48, Issue 58 https://doi.org/10.1039/c2cc33410k	journal	January 2012
Electrochemical Oxidation of Cholesterol Catalyzed by Cholesterol Oxidase with Use of an Artificial Electron Mediator Nakaminami, Takahiro; Kuwabata, Susumu; Yoneyama, Hiroshi Analytical Chemistry, Vol. 69, Issue 13 https://doi.org/10.1021/ac960996p	journal	July 1997
An improved HPLC method to purify erythrocyte cholesterol for estimation of in vivo cholesterol synthesis using the deuterium method Wong, William W.; Hachey, David L.; Clarke, Lucinda L. Applied Radiation and Isotopes, Vol. 45, Issue 4 https://doi.org/10.1016/0969-8043(94)90121-X	journal	April 1994
Recognition of aromatic amino acids and proteins with p -sulfonatocalix[4]arene - A luminescence and theoretical approach: BINDING OF AROMATIC AMINO ACIDS AND PROTEINS Muthu Mareeswaran, Paulpandian; Prakash, Muthuramalingam; Subramanian, Venkatesan Journal of Physical Organic Chemistry, Vol. 25, Issue 12 https://doi.org/10.1002/poc.2996	journal	December 2012
Study on the intermolecular complexation behavior between p-sulfonatocalix[4]arene with l-tyrosine Zhang, Guomei; Li, Yinghui; Zhao, Xuan Journal of Inclusion Phenomena and Macrocyclic Chemistry, Vol. 72, Issue 3-4 https://doi.org/10.1007/s10847-011-9963-0	journal	May 2011
Novel Cavity Design Using Calix[ n ]arene Skeletons: Toward Molecular Recognition and Metal Binding Ikeda, Atsushi; Shinkai, Seiji Chemical Reviews, Vol. 97, Issue 5 https://doi.org/10.1021/cr960385x	journal	August 1997
Cyclodextrin-carbon nanotube composites for fluorescent detection of cholesterol Gilbert, Simeon; Jeong, Hae Kyung; Dowben, P. A. Chemical Physics Letters, Vol. 687 https://doi.org/10.1016/j.cplett.2017.09.024	journal	November 2017

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
p-sulfonatocalix[4]arene
rhodamine 6G
cholesterol
reduced graphite oxide
carbon nanotube
host–guest complex

Title: Fluorescent detection of cholesterol using p-Sulfonatocalix[4]arene functionalized carbon nanotubes and thermally reduced graphite oxide composites

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