Nano on micro: tuning microbial metabolisms by nano-based artificial mediators to enhance and expand production of biochemicals

Chen, Zhu; Zhou, Junping; Wang, Yifen; Wang, Yi

doi:10.1016/j.copbio.2020.03.006

Title: Nano on micro: tuning microbial metabolisms by nano-based artificial mediators to enhance and expand production of biochemicals

Journal Article · Thu Apr 30 00:00:00 EDT 2020 · Current Opinion in Biotechnology

DOI:https://doi.org/10.1016/j.copbio.2020.03.006· OSTI ID:1799515

Chen, Zhu ^[1]; Zhou, Junping ^[1];

^[1]; Wang, Yi ^[1]

Auburn Univ., AL (United States)

Advances in synthetic biology and metabolic engineering across the past few decades have enabled the successful production of many novel chemicals. However, bioproduction of such chemicals is often limited by low yield and titer due to disrupted metabolic homeostasis. Finely tuning cellular metabolism to restore robust metabolic functions entails various genetic modifications, which is often not practical. Alternatively, artificial mediators capable of tailoring microbial metabolisms open a new avenue for restoring physiological functions. In this context, nanoparticle-based artificial mediators have been pursued to tune cellular metabolisms. They can not only enhance production of molecules from endogenous metabolism, but also expand bioproducts spectrum. Here, we reviewed recent advances toward the employment of nano-based artificial mediators for the tuning of cellular metabolism, with a focus on their positive effects on electron transfer and pathway flux. Perspectives for potential applications of artificial mediators for mediating microbial metabolisms in the future were also provided.

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Research Organization:: Auburn Univ., AL (United States)

Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE), Transportation Office. Vehicle Technologies Office; USDOE Office of Energy Efficiency and Renewable Energy (EERE)

Grant/Contract Number:: EE0008483

OSTI ID:: 1799515

Alternate ID(s):: OSTI ID: 1616641

Journal Information:: Current Opinion in Biotechnology, Vol. 64; ISSN 0958-1669

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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