Effects of the microalgae Chlamydomonas on gastrointestinal health

Fields, Francis J.; Lejzerowicz, Franck; Schroeder, Dave; Ngoi, Soo M.; Tran, Miller; McDonald, Daniel; Jiang, Lingjing; Chang, John T.; Knight, Rob; Mayfield, Stephen

doi:10.1016/j.jff.2019.103738

Effects of the microalgae Chlamydomonas on gastrointestinal health

Journal Article · Sat Feb 01 00:00:00 EST 2020 · Journal of Functional Foods

DOI:https://doi.org/10.1016/j.jff.2019.103738· OSTI ID:1799472

Fields, Francis J. ^[1]; Lejzerowicz, Franck ^[2]; Schroeder, Dave ^[3]; Ngoi, Soo M. ^[4]; Tran, Miller ^[3]; McDonald, Daniel ^[5]; Jiang, Lingjing ^[5]; Chang, John T. ^[4]; Knight, Rob ^[6]; Mayfield, Stephen ^[7]

Univ. of California, San Diego, La Jolla, CA (United States). The California Center for Algae Biotechnology; Univ. of California, San Diego, La Jolla, CA (United States). Division of Biological Sciences; OSTI
Univ. of California, San Diego, La Jolla, CA (United States). Center for Microbiome Innovation
Triton Algae Innovations, San Diego, CA (United States)
Univ. of California, San Diego, La Jolla, CA (United States). Dept. of Medicine
Univ. of California, San Diego, La Jolla, CA (United States). Dept. of Pediatrics
Univ. of California, San Diego, La Jolla, CA (United States). Center for Microbiome Innovation; Univ. of California, San Diego, La Jolla, CA (United States). Dept. of Pediatrics; Univ. of California, San Diego, La Jolla, CA (United States). Dept. of Computer Science; Univ. of California, San Diego, La Jolla, CA (United States). Dept. of Bioengineering
Univ. of California, San Diego, La Jolla, CA (United States). The California Center for Algae Biotechnology; Univ. of California, San Diego, La Jolla, CA (United States). Division of Biological Sciences

The effects of consuming whole-cell biomass of the green algae Chlamydomonas reinhardtii on gastrointestinal health in mice and humans was examined. A 14-day murine model of acute colitis revealed significantly less weight loss in mice that received C. reinhardtii biomass by oral gavage. Based on this result, human volunteers with varying gastrointestinal symptoms were asked to consume 1 or 3 g of C. reinhardtii daily for 30 days. Participants reported changes in their gastrointestinal health through a questionnaire and provided stool samples to analyze the composition of their gut microbiome. Those who typically experience frequent gastrointestinal symptoms reported significantly less bowel discomfort or diarrhea, significantly less gas or bloating, more regular bowel movements, and better stool consistency when regularly consuming C. reinhardtii. Analysis of participant stool samples suggested the gut microbiome composition in all groups remained complex, and no signs of dysbiosis or adverse effect on microbial composition were observed.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of California, San Diego, CA (United States)

Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE)

Grant/Contract Number:: EE0008246

OSTI ID:: 1799472

Journal Information:: Journal of Functional Foods, Journal Name: Journal of Functional Foods Journal Issue: C Vol. 65; ISSN 1756-4646

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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