skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity

Journal Article · · Metabolic Engineering

Not provided.

Research Organization:
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
Sponsoring Organization:
USDOE Office of Energy Efficiency and Renewable Energy (EERE)
DOE Contract Number:
EE0007531; SC0008744
OSTI ID:
1799302
Journal Information:
Metabolic Engineering, Vol. 61, Issue C; ISSN 1096-7176
Publisher:
Elsevier
Country of Publication:
United States
Language:
English

References (36)

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli journal September 2010
Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli journal May 2005
Production of isoprenoid pharmaceuticals by engineered microbes journal November 2006
Current development in isoprenoid precursor biosynthesis and regulation journal August 2013
Two-step pathway for isoprenoid synthesis journal December 2018
Synthetic and systems biology for microbial production of commodity chemicals journal April 2016
The isoprenoid alcohol pathway, a synthetic route for isoprenoid biosynthesis journal June 2019
Metabolic engineering of Saccharomyces cerevisiae for production of butanol isomers journal June 2015
Lycopene: Progress in microbial production journal October 2016
Introduction: Natural Product Synthesis journal August 2017
Paclitaxel: biosynthesis, production and future prospects journal May 2014
Recent advances in bioengineering of the oleaginous yeast Yarrowia lipolytica journal January 2016
Extraction and Analysis of Terpenes/Terpenoids journal March 2016
The isoprenoid pathway and transcriptional response to its inhibitors in the yeast Saccharomyces cerevisiae journal February 2010
Constructing Tailored Isoprenoid Products by Structure-Guided Modification of Geranylgeranyl Reductase journal July 2014
Yarrowia lipolytica as a biotechnological chassis to produce usual and unusual fatty acids journal January 2016
Biotechnological applications of Yarrowia lipolytica: Past, present and future journal December 2015
13C Metabolic Flux Analysis of acetate conversion to lipids by Yarrowia lipolytica journal November 2016
Isoprenoid biosynthesis in eukaryotic phototrophs: A spotlight on algae journal April 2012
An Artificial Pathway for Isoprenoid Biosynthesis Decoupled from Native Hemiterpene Metabolism journal January 2019
Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene journal March 2019
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids journal June 2003
Production of Lycopene in the Non-Carotenoid-Producing Yeast Yarrowia lipolytica journal December 2013
Occurrence, biosynthesis and function of isoprenoid quinones journal September 2010
Isoprenoid lipid chains increase membrane resistance to pore formation journal October 2014
Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism journal January 2017
Regulation of lipid accumulation in oleaginous micro-organisms journal November 2002
Exploring natural biodiversity to expand access to microbial terpene synthesis journal February 2019
Standardized Markerless Gene Integration for Pathway Engineering in Yarrowia lipolytica journal November 2016
Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production journal January 2013
Recent advances in synthetic biology for engineering isoprenoid production in yeast journal October 2017
Metabolic engineering of Escherichia coli for the production of isoprenoids journal March 2018
Cell free biosynthesis of isoprenoids from isopentenol
  • Ward, Valerie C. A.; Chatzivasileiou, Alkiviadis Orfefs; Stephanopoulos, Gregory
  • Biotechnology and Bioengineering, Vol. 116, Issue 12 https://doi.org/10.1002/bit.27146
journal September 2019
The oxidative pentose phosphate pathway is the primary source of NADPH for lipid overproduction from glucose in Yarrowia lipolytica journal July 2015
Improved squalene production through increasing lipid contents in Saccharomyces cerevisiae journal April 2018
Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals journal September 2016

Similar Records

Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity
Journal Article · Tue Sep 01 00:00:00 EDT 2020 · Metabolic Engineering · OSTI ID:1799302

Cell free biosynthesis of isoprenoids from isopentenol
Journal Article · Tue Aug 20 00:00:00 EDT 2019 · Biotechnology and Bioengineering · OSTI ID:1799302

Two-step pathway for isoprenoid synthesis
Journal Article · Mon Dec 24 00:00:00 EST 2018 · Proceedings of the National Academy of Sciences of the United States of America · OSTI ID:1799302