High-sensitivity in vivo contrast for ultra-low field magnetic resonance imaging using superparamagnetic iron oxide nanoparticles

Waddington, David E.  J.; Boele, Thomas; Maschmeyer, Richard; Kuncic, Zdenka; Rosen, Matthew S.

doi:10.1126/sciadv.abb0998

High-sensitivity in vivo contrast for ultra-low field magnetic resonance imaging using superparamagnetic iron oxide nanoparticles

Journal Article · Fri Jul 17 00:00:00 EDT 2020 · Science Advances

DOI:https://doi.org/10.1126/sciadv.abb0998· OSTI ID:1799100

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Univ. of Sydney, NSW (Australia). School of Physics. Inst. of Medical Physics; A. A. Martinos Center for Biomedical Imaging, Charlestown, MA (United States); Univ. of Sydney, NSW (Australia). Faculty of Medicine and Health. ACRF Image X Inst.; OSTI
A. A. Martinos Center for Biomedical Imaging, Charlestown, MA (United States); Univ. of Sydney, NSW (Australia). School of Physics. ARC Centre of Excellence for Engineered Quantum Systems
Univ. of Sydney, NSW (Australia). School of Physics. Inst. of Medical Physics
Univ. of Sydney, NSW (Australia). School of Physics. Inst. of Medical Physics.; Univ. of Sydney, NSW (Australia). Nano Inst.
A. A. Martinos Center for Biomedical Imaging, Charlestown, MA (United States); Harvard Univ., Cambridge, MA (United States). Dept. of Physics; Harvard Medical School, Boston, MA (United States)

Magnetic resonance imaging (MRI) scanners operating at ultra-low magnetic fields (ULF; <10 mT) are uniquely positioned to reduce the cost and expand the clinical accessibility of MRI. A fundamental challenge for ULF MRI is obtaining high-contrast images without compromising acquisition sensitivity to the point that scan times become clinically unacceptable. Here, we demonstrate that the high magnetization of superparamagnetic iron oxide nanoparticles (SPIONs) at ULF makes possible relaxivity- and susceptibility-based effects unachievable with conventional contrast agents (CAs). We leverage these effects to acquire high-contrast images of SPIONs in a rat model with ULF MRI using short scan times. This work overcomes a key limitation of ULF MRI by enabling in vivo imaging of biocompatible CAs. These results open a new clinical translation pathway for ULF MRI and have broader implications for disease detection with low-field portable MRI scanners.

View Accepted Manuscript (DOE)

Research Organization:: Texas A & M Univ., College Station, TX (United States). Texas A & M AgriLife Research

Sponsoring Organization:: USDOE Advanced Research Projects Agency - Energy (ARPA-E)

Grant/Contract Number:: AR0000823

OSTI ID:: 1799100

Journal Information:: Science Advances, Journal Name: Science Advances Journal Issue: 29 Vol. 6; ISSN 2375-2548

Publisher:: AAASCopyright Statement

Country of Publication:: United States

Language:: English

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