Rapid custom prototyping of soft poroelastic biosensor for simultaneous epicardial recording and imaging

Kim, Bongjoong; Soepriatna, Arvin H.; Park, Woohyun; Moon, Haesoo; Cox, Abigail; Zhao, Jianchao; Gupta, Nevin S.; Park, Chi Hoon; Kim, Kyunghun; Jeon, Yale; Jang, Hanmin; Kim, Dong Rip; Lee, Hyowon; Lee, Kwan-Soo; Goergen, Craig J.; Lee, Chi Hwan

doi:10.1038/s41467-021-23959-3

Title: Rapid custom prototyping of soft poroelastic biosensor for simultaneous epicardial recording and imaging

Journal Article · Thu Jun 17 00:00:00 EDT 2021 · Nature Communications

DOI:https://doi.org/10.1038/s41467-021-23959-3· OSTI ID:1797517

Kim, Bongjoong;

;

; Moon, Haesoo;

; Zhao, Jianchao; Gupta, Nevin S.; Park, Chi Hoon; Kim, Kyunghun; Jeon, Yale;

;

The growing need for the implementation of stretchable biosensors in the body has driven rapid prototyping schemes through the direct ink writing of multidimensional functional architectures. Recent approaches employ biocompatible inks that are dispensable through an automated nozzle injection system. However, their application in medical practices remains challenged in reliable recording due to their viscoelastic nature that yields mechanical and electrical hysteresis under periodic large strains. Herein, we report sponge-like poroelastic silicone composites adaptable for high-precision direct writing of custom-designed stretchable biosensors, which are soft and insensitive to strains. Their unique structural properties yield a robust coupling to living tissues, enabling high-fidelity recording of spatiotemporal electrophysiological activity and real-time ultrasound imaging for visual feedback. In vivo evaluations of custom-fit biosensors in a murine acute myocardial infarction model demonstrate a potential clinical utility in the simultaneous intraoperative recording and imaging on the epicardium, which may guide definitive surgical treatments.

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Research Organization:: Triad National Security, LLC, Los Alamos, NM (United States); Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC52-06NA25396; 89233218CNA000001

OSTI ID:: 1797517

Alternate ID(s):: OSTI ID: 1815481; OSTI ID: 1870629

Report Number(s):: LA-UR-20-26939; 3710; PII: 23959

Journal Information:: Nature Communications, Journal Name: Nature Communications Vol. 12 Journal Issue: 1; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (50)

High-Density Stretchable Electrode Grids for Chronic Neural Recording Tybrandt, Klas; Khodagholy, Dion; Dielacher, Bernd Advanced Materials, Vol. 30, Issue 15 https://doi.org/10.1002/adma.201706520	journal	February 2018
3D Printing of PDMS Improves Its Mechanical and Cell Adhesion Properties Ozbolat, Veli; Dey, Madhuri; Ayan, Bugra ACS Biomaterials Science & Engineering, Vol. 4, Issue 2 https://doi.org/10.1021/acsbiomaterials.7b00646	journal	June 2017
Generic Top-Functionalization of Patterned Antifouling Zwitterionic Polymers on Indium Tin Oxide Li, Yan; Giesbers, Marcel; Gerth, Marieke Langmuir, Vol. 28, Issue 34 https://doi.org/10.1021/la3022563	journal	August 2012
Rheological Modification of Liquid Metal for Additive Manufacturing of Stretchable Electronics Daalkhaijav, Uranbileg; Yirmibesoglu, Osman Dogan; Walker, Stephanie Advanced Materials Technologies, Vol. 3, Issue 4 https://doi.org/10.1002/admt.201700351	journal	February 2018
Mechanical vs. electrical hysteresis of carbon nanotube/styrene–butadiene–styrene composites and their influence in the electromechanical response Costa, P.; Ribeiro, S.; Lanceros-Mendez, S. Composites Science and Technology, Vol. 109 https://doi.org/10.1016/j.compscitech.2015.01.006	journal	March 2015
ST-segment elevation: Distinguishing ST elevation myocardial infarction from ST elevation secondary to nonischemic etiologies Deshpande, Alok World Journal of Cardiology, Vol. 6, Issue 10 https://doi.org/10.4330/wjc.v6.i10.1067	journal	January 2014
3D Printed Functional and Biological Materials on Moving Freeform Surfaces Zhu, Zhijie; Guo, Shuang-Zhuang; Hirdler, Tessa Advanced Materials, Vol. 30, Issue 23 https://doi.org/10.1002/adma.201707495	journal	April 2018
Three-dimensional myocardial strain correlates with murine left ventricular remodelling severity post-infarction Soepriatna, Arvin H.; Yeh, A. Kevin; Clifford, Abigail D. Journal of The Royal Society Interface, Vol. 16, Issue 160 https://doi.org/10.1098/rsif.2019.0570	journal	November 2019
Materials and Fractal Designs for 3D Multifunctional Integumentary Membranes with Capabilities in Cardiac Electrotherapy Xu, Lizhi; Gutbrod, Sarah R.; Ma, Yinji Advanced Materials, Vol. 27, Issue 10 https://doi.org/10.1002/adma.201405017	journal	January 2015
3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Xu, Lizhi; Gutbrod, Sarah R.; Bonifas, Andrew P. Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms4329	journal	February 2014
Hybrid 3D Printing of Soft Electronics Valentine, Alexander D.; Busbee, Travis A.; Boley, John William Advanced Materials, Vol. 29, Issue 40 https://doi.org/10.1002/adma.201703817	journal	September 2017
The Electrophysiological Cardiac Ventricular Substrate in Patients After Myocardial Infarction Cuculich, Phillip S.; Zhang, Junjie; Wang, Yong Journal of the American College of Cardiology, Vol. 58, Issue 18 https://doi.org/10.1016/j.jacc.2011.07.029	journal	October 2011
Surface hydration for antifouling and bio-adhesion Del Grosso, Chelsey A.; Leng, Chuan; Zhang, Kexin Chemical Science, Vol. 11, Issue 38 https://doi.org/10.1039/D0SC03690K	journal	January 2020
A two year in vivo study of polyvinyl alcohol-hydrogel (PVA-H) artificial meniscus Kobayashi, Masanori; Chang, Yong-Shun; Oka, Masanori Biomaterials, Vol. 26, Issue 16 https://doi.org/10.1016/j.biomaterials.2004.08.028	journal	June 2005
3D printed deformable sensors Zhu, Zhijie; Park, Hyun Soo; McAlpine, Michael C. Science Advances, Vol. 6, Issue 25 https://doi.org/10.1126/sciadv.aba5575	journal	June 2020
A photonic sintering derived Ag flake/nanoparticle-based highly sensitive stretchable strain sensor for human motion monitoring Kim, Inhyuk; Woo, Kyoohee; Zhong, Zhaoyang Nanoscale, Vol. 10, Issue 17 https://doi.org/10.1039/C7NR09421C	journal	January 2018
Biocompatibility of polymer-based biomaterials and medical devices – regulations, in vitro screening and risk-management Bernard, Mélisande; Jubeli, Emile; Pungente, Michael D. Biomaterials Science, Vol. 6, Issue 8 https://doi.org/10.1039/C8BM00518D	journal	January 2018
Emerging Modalities and Implantable Technologies for Neuromodulation Won, Sang Min; Song, Enming; Reeder, Jonathan T. Cell, Vol. 181, Issue 1 https://doi.org/10.1016/j.cell.2020.02.054	journal	April 2020
Highly Stretchable and Sensitive Strain Sensor Based on Silver Nanowire–Elastomer Nanocomposite Amjadi, Morteza; Pichitpajongkit, Aekachan; Lee, Sangjun ACS Nano, Vol. 8, Issue 5 https://doi.org/10.1021/nn501204t	journal	April 2014
Inkjet-printed stretchable and low voltage synaptic transistor array Molina-Lopez, F.; Gao, T. Z.; Kraft, U. Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-10569-3	journal	June 2019
Nanoporous materials for biomedical devices Adiga, Shashishekar P.; Curtiss, Larry A.; Elam, Jeffrey W. JOM, Vol. 60, Issue 3 https://doi.org/10.1007/s11837-008-0028-9	journal	March 2008
A New Frontier of Printed Electronics: Flexible Hybrid Electronics Khan, Yasser; Thielens, Arno; Muin, Sifat Advanced Materials, Vol. 32, Issue 15 https://doi.org/10.1002/adma.201905279	journal	April 2020
Intrinsically stretchable electrode array enabled in vivo electrophysiological mapping of atrial fibrillation at cellular resolution Liu, Jia; Zhang, Xinyuan; Liu, Yuxin Proceedings of the National Academy of Sciences, Vol. 117, Issue 26 https://doi.org/10.1073/pnas.2000207117	journal	June 2020
Zwitterionic liquid crystalline polythiophene as an antibiofouling biomaterial Xu, Jinjia; Xu, Jian; Moon, Haesoo Journal of Materials Chemistry B, Vol. 9, Issue 2 https://doi.org/10.1039/D0TB02264K	journal	January 2021
SimVascular: An Open Source Pipeline for Cardiovascular Simulation Updegrove, Adam; Wilson, Nathan M.; Merkow, Jameson Annals of Biomedical Engineering, Vol. 45, Issue 3 https://doi.org/10.1007/s10439-016-1762-8	journal	December 2016
Gold-Plated Electrode with High Scratch Strength for Electrophysiological Recordings Vafaiee, Mohaddeseh; Vossoughi, Manouchehr; Mohammadpour, Raheleh Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-39138-w	journal	February 2019
Highly conductive, stretchable and biocompatible Ag–Au core–sheath nanowire composite for wearable and implantable bioelectronics Choi, Suji; Han, Sang Ihn; Jung, Dongjun Nature Nanotechnology, Vol. 13, Issue 11 https://doi.org/10.1038/s41565-018-0226-8	journal	August 2018
Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing Lind, Johan U.; Busbee, Travis A.; Valentine, Alexander D. Nature Materials, Vol. 16, Issue 3 https://doi.org/10.1038/nmat4782	journal	October 2016
Structural Effect on Electrochemical Performance of Ordered Porous Carbon Electrodes for Na-Ion Batteries Jo, Changshin; Park, Yuwon; Jeong, Jooyoung ACS Applied Materials & Interfaces, Vol. 7, Issue 22 https://doi.org/10.1021/acsami.5b03186	journal	May 2015
Enhancing the Performance of Stretchable Conductors for E‐Textiles by Controlled Ink Permeation Jin, Hanbit; Matsuhisa, Naoji; Lee, Sungwon Advanced Materials, Vol. 29, Issue 21 https://doi.org/10.1002/adma.201605848	journal	March 2017
Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics Kim, Dae-Hyeong; Viventi, Jonathan; Amsden, Jason J. Nature Materials, Vol. 9, Issue 6, p. 511-517 https://doi.org/10.1038/nmat2745	journal	April 2010
One-Step Large-Scale Nanotexturing of Nonplanar PTFE Surfaces to Induce Bactericidal and Anti-inflammatory Properties Xu, Jian; Moon, Haesoo; Xu, Jinjia ACS Applied Materials & Interfaces, Vol. 12, Issue 24 https://doi.org/10.1021/acsami.0c04729	journal	May 2020
Ink Development and Printing of Conducting Polymers for Intrinsically Stretchable Interconnects and Circuits Kraft, Ulrike; Molina‐Lopez, Francisco; Son, Donghee Advanced Electronic Materials, Vol. 6, Issue 1 https://doi.org/10.1002/aelm.201900681	journal	November 2019
A Rubberlike Stretchable Active Matrix Using Elastic Conductors Sekitani, Tsuyoshi; Noguchi, Yoshiaki; Hata, Kenji Science, Vol. 321, Issue 5895, p. 1468-1472 https://doi.org/10.1126/science.1160309	journal	September 2008
Concomitant wrinkling and buckle-delamination of elastic thin films on compliant substrates Mei, Haixia; Landis, Chad M.; Huang, Rui Mechanics of Materials, Vol. 43, Issue 11 https://doi.org/10.1016/j.mechmat.2011.08.003	journal	November 2011
Characterization of a Low Cost, Automated and Field Deployable 2-Lead Myocardial Infarction Detection System Arora, Neha; Mishra, Biswajit 2020 International Conference on COMmunication Systems & NETworkS (COMSNETS) https://doi.org/10.1109/COMSNETS48256.2020.9027451	conference	January 2020
Electrically conductive polymer composites for smart flexible strain sensors: a critical review Liu, Hu; Li, Qianming; Zhang, Shuaidi Journal of Materials Chemistry C, Vol. 6, Issue 45 https://doi.org/10.1039/C8TC04079F	journal	January 2018
Zwitterionic Porous Conjugated Polymers as a Versatile Platform for Antibiofouling Implantable Bioelectronics Xu, Jinjia; Xu, Jian; Moon, Haesoo ACS Applied Polymer Materials, Vol. 2, Issue 2 https://doi.org/10.1021/acsapm.9b00950	journal	December 2019
Three dimensional core-shell structured liquid metal/elastomer composite via coaxial direct ink writing for electromagnetic interference shielding Wang, Zhenyu; Ren, Jun; Liu, Rui Composites Part A: Applied Science and Manufacturing, Vol. 136 https://doi.org/10.1016/j.compositesa.2020.105957	journal	September 2020
Strain- and Strain-Rate-Invariant Conductance in a Stretchable and Compressible 3D Conducting Polymer Foam Chen, Gan; Rastak, Reza; Wang, Yue Matter, Vol. 1, Issue 1 https://doi.org/10.1016/j.matt.2019.03.011	journal	July 2019
Galectin-1 in Early Acute Myocardial Infarction Al-Salam, Suhail; Hashmi, Satwat PLoS ONE, Vol. 9, Issue 1 https://doi.org/10.1371/journal.pone.0086994	journal	January 2014
Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging Lang, Roberto M.; Badano, Luigi P.; Mor-Avi, Victor European Heart Journal – Cardiovascular Imaging, Vol. 16, Issue 3 https://doi.org/10.1093/ehjci/jev014	journal	February 2015
Biomechanics and repair of articular cartilge Oka, Masanori Journal of Orthopaedic Science, Vol. 6, Issue 5 https://doi.org/10.1007/s007760170014	journal	September 2001
Embedded 3D Printing of Strain Sensors within Highly Stretchable Elastomers Muth, Joseph T.; Vogt, Daniel M.; Truby, Ryan L. Advanced Materials, Vol. 26, Issue 36, p. 6307-6312 https://doi.org/10.1002/adma.201400334	journal	June 2014
High-Performance, Transparent, and Stretchable Electrodes Using Graphene–Metal Nanowire Hybrid Structures Lee, Mi-Sun; Lee, Kyongsoo; Kim, So-Yun Nano Letters, Vol. 13, Issue 6 https://doi.org/10.1021/nl401070p	journal	May 2013
Measuring left ventricular volume and ejection fraction with the biplane Simpson's method Otterstad, J. E. Heart, Vol. 88, Issue 6 https://doi.org/10.1136/heart.88.6.559	journal	December 2002
Integrated Printed Microfluidic Biosensors Loo, Jacky F. C.; Ho, Aaron H. P.; Turner, Anthony P. F. Trends in Biotechnology, Vol. 37, Issue 10 https://doi.org/10.1016/j.tibtech.2019.03.009	journal	October 2019
Solderable and electroplatable flexible electronic circuit on a porous stretchable elastomer Jeong, Gi Seok; Baek, Dong-Hyun; Jung, Ha Chul Nature Communications, Vol. 3, Issue 1 https://doi.org/10.1038/ncomms1980	journal	January 2012
Metal nanowire percolation micro-grids embedded in elastomers for stretchable and transparent conductors Park, Sang-Min; Jang, Nam-Su; Ha, Sung-Hun Journal of Materials Chemistry C, Vol. 3, Issue 31 https://doi.org/10.1039/C5TC00740B	journal	January 2015
Direct Ink Writing of 3D Functional Materials Lewis, J. A. Advanced Functional Materials, Vol. 16, Issue 17 https://doi.org/10.1002/adfm.200600434	journal	November 2006

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Title: Rapid custom prototyping of soft poroelastic biosensor for simultaneous epicardial recording and imaging

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