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Title: Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome

Journal Article · · J. Med. Chem.

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY; National Institutes of Health (NIH)
OSTI ID:
1797476
Journal Information:
J. Med. Chem., Vol. 64, Issue (9)
Country of Publication:
United States
Language:
ENGLISH

References (47)

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Prokaryotic Ubiquitin-Like Protein Provides a Two-Part Degron to Mycobacterium Proteasome Substrates journal June 2010
Proteasome substrate capture and gate opening by the accessory factor PafE from Mycobacterium tuberculosis journal March 2018
Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis journal March 2016
The Mycobacterium tuberculosis Proteasome Active Site Threonine Is Essential for Persistence Yet Dispensable for Replication and Resistance to Nitric Oxide journal August 2010
Inhibitors selective for mycobacterial versus human proteasomes journal September 2009
N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets journal June 2013
Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome journal September 2019
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The exploration of macrocycles for drug discovery — an underexploited structural class journal July 2008
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Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti‐malaria Activity in Humanized Mice journal March 2021
New 26S Proteasome Inhibitors with High Selectivity for Chymotrypsin-Like Activity and p53-Dependent Cytotoxicity journal November 2012
Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome journal December 2016
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“Depupylation” of Prokaryotic Ubiquitin-like Protein from Mycobacterial Proteasome Substrates journal September 2010
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Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2 journal April 2014
Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in vitro journal February 2020
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The mycobacterial Mpa–proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminus journal March 2010
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Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation journal October 2010
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