Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyl

Ji, Zhiqin; Clark, Richard F.; Bhat, Vikram; Hansen, T. Matthew; Lasko, Loren M.; Bromberg, Kenneth D.; Manaves, Vlasios; Algire, Mikkel; Martin, Ruth; Qiu, Wei; Torrent, Maricel; Jakob, Clarissa G.; Liu, Hong; Cole, Philip A.; Marmorstein, Ronen; Kesicki, Edward A.; Lai, Albert; Michaelides, Michael R.

doi:10.1016/j.bmcl.2021.127854

Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyl

Journal Article · Sat May 01 04:00:00 EDT 2021 · Bioorg. Med. Chem. Lett.

DOI:https://doi.org/10.1016/j.bmcl.2021.127854· OSTI ID:1787769

Ji, Zhiqin; Clark, Richard F.; Bhat, Vikram; Hansen, T. Matthew; Lasko, Loren M.; Bromberg, Kenneth D.; Manaves, Vlasios; Algire, Mikkel; Martin, Ruth; Qiu, Wei; Torrent, Maricel; Jakob, Clarissa G.; Liu, Hong; Cole, Philip A.; Marmorstein, Ronen; Kesicki, Edward A.; Lai, Albert; Michaelides, Michael R.

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; INDUSTRY

OSTI ID:: 1787769

Journal Information:: Bioorg. Med. Chem. Lett., Journal Name: Bioorg. Med. Chem. Lett. Vol. 39

Country of Publication:: United States

Language:: ENGLISH

References (15)

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Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases Bedford, David C.; Kasper, Lawryn H.; Fukuyama, Tomofusa Epigenetics, Vol. 5, Issue 1 https://doi.org/10.4161/epi.5.1.10449	journal	January 2010
Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation: Histone acetylation and gene activation Jin, Qihuang; Yu, Li-Rong; Wang, Lifeng The EMBO Journal, Vol. 30, Issue 2 https://doi.org/10.1038/emboj.2010.318	journal	December 2010
Super-Enhancers in the Control of Cell Identity and Disease Hnisz, Denes; Abraham, Brian J.; Lee, Tong Ihn Cell, Vol. 155, Issue 4 https://doi.org/10.1016/j.cell.2013.09.053	journal	November 2013
p300/CBP proteins: HATs for transcriptional bridges and scaffolds Chan, Ho Man; La Thangue, Nicholas B. Journal of Cell Science, Vol. 114, Issue 13 https://doi.org/10.1242/jcs.114.13.2363	journal	July 2001
CBP and p300: HATs for different occasions Kalkhoven, Eric Biochemical Pharmacology, Vol. 68, Issue 6 https://doi.org/10.1016/j.bcp.2004.03.045	journal	September 2004
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator Liu, Xin; Wang, Ling; Zhao, Kehao Nature, Vol. 451, Issue 7180 https://doi.org/10.1038/nature06546	journal	February 2008
Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases Michaelides, Michael R.; Kluge, Arthur; Patane, Michael ACS Medicinal Chemistry Letters, Vol. 9, Issue 1 https://doi.org/10.1021/acsmedchemlett.7b00395	journal	December 2017
p300/CBP and cancer Iyer, Narayanan Gopalakrishna; Özdag, Hilal; Caldas, Carlos Oncogene, Vol. 23, Issue 24 https://doi.org/10.1038/sj.onc.1207118	journal	May 2004
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors Yang, Yaxi; Zhang, Rukang; Li, Zhaojun Journal of Medicinal Chemistry, Vol. 63, Issue 3 https://doi.org/10.1021/acs.jmedchem.9b01721	journal	January 2020
Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function Wang, Ling; Tang, Yong; Cole, Philip A. Current Opinion in Structural Biology, Vol. 18, Issue 6 https://doi.org/10.1016/j.sbi.2008.09.004	journal	December 2008
The many roles of histone deacetylases in development and physiology: implications for disease and therapy Haberland, Michael; Montgomery, Rusty L.; Olson, Eric N. Nature Reviews Genetics, Vol. 10, Issue 1 https://doi.org/10.1038/nrg2485	journal	January 2009
Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor Wilson, Jonathan E.; Patel, Gaurav; Patel, Chirag ACS Medicinal Chemistry Letters, Vol. 11, Issue 6 https://doi.org/10.1021/acsmedchemlett.0c00155	journal	April 2020
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours Lasko, Loren M.; Jakob, Clarissa G.; Edalji, Rohinton P. Nature, Vol. 550, Issue 7674 https://doi.org/10.1038/nature24028	journal	September 2017
Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition Wang, Feng; Marshall, Christopher B.; Ikura, Mitsuhiko Cellular and Molecular Life Sciences, Vol. 70, Issue 21 https://doi.org/10.1007/s00018-012-1254-4	journal	January 2013

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