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September 2006 |
Geometrical reaction coordinates. II. Nucleophilic addition to a carbonyl group
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July 1973 |
Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226
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February 2012 |
Carbapenemases: the Versatile -Lactamases
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July 2007 |
Overview of the CCP 4 suite and current developments
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March 2011 |
β-Lactamases: A Focus on Current Challenges
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October 2016 |
Enzyme Architecture: Amino Acid Side-Chains That Function To Optimize the Basicity of the Active Site Glutamate of Triosephosphate Isomerase
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June 2018 |
Carbapenems and SHV-1 β-Lactamase Form Different Acyl-Enzyme Populations in Crystals and Solution †
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November 2008 |
Facilitation of the .DELTA.2 .fwdarw. .DELTA.1 pyrroline tautomerization of carbapenem antibiotics by the highly conserved arginine-244 of class A .beta.-lactamases during the course of turnover
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February 1992 |
Single-turnover and steady-state kinetics of hydrolysis of cephalosporins by β-lactamase I from Bacillus cereus
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October 1985 |
The ficin-catalysed hydrolysis of p -nitrophenyl hippurate. Detailed kinetics including the measurement of the apparent dissociation constant for the enzyme-substrate complex
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August 1969 |
Negative Epistasis and Evolvability in TEM-1 β-Lactamase—The Thin Line between an Enzyme's Conformational Freedom and Disorder
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July 2015 |
β-Lactams and β-Lactamase Inhibitors: An Overview
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June 2016 |
Tightly regulated tac promoter vectors useful for the expression of unfused and fused proteins in Escherichia coli
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September 1988 |
Three Decades of the Class A β-Lactamase Acyl-Enzyme
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October 2009 |
Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae
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October 2010 |
Substrate Selectivity and a Novel Role in Inhibitor Discrimination by Residue 237 in the KPC-2 β-Lactamase
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July 2010 |
Population Genomic Analysis of 1,777 Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Isolates, Houston, Texas: Unexpected Abundance of Clonal Group 307
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May 2017 |
Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability
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June 2015 |
Genetic and Structural Insights into the Dissemination Potential of the Extremely Broad-Spectrum Class A β-Lactamase KPC-2 Identified in an Escherichia coli Strain and an Enterobacter cloacae Strain Isolated from the Same Patient in France
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October 2008 |
Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates
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April 2006 |
Effects on Substrate Profile by Mutational Substitutions at Positions 164 and 179 of the Class A TEMpUC19 β-Lactamase from Escherichia coli
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August 1999 |
Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation
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September 2019 |
Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study
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September 2015 |
Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D β-Lactamases
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December 2018 |
Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae
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April 2001 |
UCSF Chimera?A visualization system for exploratory research and analysis
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January 2004 |
The Structure of <latex>$\beta$</latex>-Lactamases
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May 1980 |
Synergistic effects of functionally distinct substitutions in β-lactamase variants shed light on the evolution of bacterial drug resistance
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October 2018 |
Evolution of antibiotic resistance: several different amino acid substitutions in an active site loop alter the substrate profile of ?-lactamase
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April 1994 |
Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases
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February 2018 |
Amino Acid Residues That Contribute to Substrate Specificity of Class A β-Lactamase SME-1
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August 2005 |
A clogged gutter mechanism for protease inhibitors
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July 2002 |
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM
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March 2011 |
A drug-resistant β-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency
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December 2020 |
Crystal Structure of KPC-2: Insights into Carbapenemase Activity in Class A β-Lactamases † , ‡
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May 2007 |
The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace
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February 2017 |
Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A β-Lactamases from the Antibiotic-Resistant Bacteria
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September 1998 |
Magnitude and Origin of the Enhanced Basicity of the Catalytic Glutamate of Triosephosphate Isomerase
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April 2013 |
The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with Doripenem
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December 2009 |
Metallo-β-lactamase structure and function: Metallo-β-lactamase structure and function
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November 2012 |
Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance
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May 2020 |
Coot model-building tools for molecular graphics
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November 2004 |
Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2)
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April 2017 |
Features and development of Coot
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March 2010 |
Inhibition of Class A β-Lactamases by Carbapenems: Crystallographic Observation of Two Conformations of Meropenem in SHV-1
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September 2008 |
Inhibition of the RTEM .beta.-lactamase from Escherichia coli. Interaction of the enzyme with derivatives of olivanic acid
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May 1981 |
Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution
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October 1992 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation
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June 2017 |
A standard numbering scheme for the class A β-lactamases
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May 1991 |
The Basis for Carbapenem Hydrolysis by Class A β-Lactamases: A Combined Investigation using Crystallography and Simulations
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October 2012 |
Molecular replacement with MOLREP
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December 2009 |
KPC-2 β-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate
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January 2021 |
What Makes a Protein Fold Amenable to Functional Innovation? Fold Polarity and Stability Trade-offs
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July 2013 |
Modelling proteins’ hidden conformations to predict antibiotic resistance
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October 2016 |
Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and its Complex with Moxalactam and Imipenem
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September 2016 |
Inhibition of the RTEM .beta.-lactamase from Escherichia coli. Interaction of the enzyme with derivatives of olivanic acid
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June 1982 |
Biochemical and Structural Characterization of Mycobacterium tuberculosis β-Lactamase with the Carbapenems Ertapenem and Doripenem
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May 2010 |
Structure–Function Studies of Hydrophobic Residues That Clamp a Basic Glutamate Side Chain during Catalysis by Triosephosphate Isomerase
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May 2016 |