One of the Substrate Waters for O2 Formation in Photosystem II Is Provided by the Water-Splitting Mn4CaO5 Cluster’s Ca2+ Ion

Kim, Christopher J.; Debus, Richard J.

doi:10.1021/acs.biochem.9b00418

Title: One of the Substrate Waters for O₂ Formation in Photosystem II Is Provided by the Water-Splitting Mn₄CaO₅ Cluster’s Ca²⁺ Ion

Journal Article · Fri Jul 05 00:00:00 EDT 2019 · Biochemistry

DOI:https://doi.org/10.1021/acs.biochem.9b00418· OSTI ID:1785444

Kim, Christopher J. ^[1];

^[1]

Univ. of California, Riverside, CA (United States)

During the catalytic step immediately prior to O–O bond formation in Photosystem II, a water molecule deprotonates and moves next to the water-splitting Mn₄CaO₅ cluster’s O5 oxo bridge. Considerable evidence identifies O5 as one of the two substrate waters that ultimately form O₂. The relocated oxygen, known as O6 or Ox, may be the second. It is currently debated whether O6 or Ox originates as the Mn-bound water denoted W2 or as the Ca²⁺-bound water denoted W3. To distinguish between these two possibilities, we analyzed the D–O–D bending mode of the water molecule that deprotonates/relocates to become O6/Ox. Here, we show that this D–O–D bending mode is not altered by the D1-S169A mutation. Previously, we showed that this D–O–D bending mode is altered substantially when Sr²⁺ is substituted for Ca²⁺. Because Sr²⁺/Ca²⁺ substitution alters this D–O–D bending mode but the D1-S169A mutation does not, we conclude that the water-derived oxygen that relocates and becomes O6/Ox derives from the Ca²⁺-bound W3. This conclusion provides an important constraint for proposed mechanisms of O–O bond formation in Photosystem II.

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Research Organization:: Univ. of California, Riverside, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences & Biosciences Division

Grant/Contract Number:: SC0005291

OSTI ID:: 1785444

Journal Information:: Biochemistry, Vol. 58, Issue 29; ISSN 0006-2960

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 24 works

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Title: One of the Substrate Waters for O₂ Formation in Photosystem II Is Provided by the Water-Splitting Mn₄CaO₅ Cluster’s Ca²⁺ Ion