Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces
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journal
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March 2016 |
Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.
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May 1995 |
KFC2: A knowledge-based hot spot prediction method based on interface solvation, atomic density, and plasticity features: KFC2: A Knowledge-Based Hot Spot Prediction Method
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July 2011 |
Identification of a receptor binding site in the carboxyl terminus of human interleukin-6.
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July 1992 |
Structure-function analysis of human interleukin-6: Evidence for the involvement of the carboxy-terminus in function
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March 1990 |
An automated decision-tree approach to predicting protein interaction hot spots
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June 2007 |
Inhibition of Classic Signaling Is a Novel Function of Soluble Glycoprotein 130 (sgp130), Which Is Controlled by the Ratio of Interleukin 6 and Soluble Interleukin 6 Receptor
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December 2011 |
CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data
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July 2013 |
Scalable molecular dynamics with NAMD
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January 2005 |
Molecular evolution of affinity and flexibility in the immune system
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May 2007 |
High-Resolution Comparative Modeling with RosettaCM
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October 2013 |
Characterizing the Diversity of the CDR-H3 Loop Conformational Ensembles in Relationship to Antibody Binding Properties
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January 2019 |
Structure-Function analysis of human IL-6: Identification of two distinct regions that are important for receptor binding
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December 1994 |
Molecular cloning and expression of an IL-6 signal transducer, gp130
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journal
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December 1990 |
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses: Soluble gp130 inhibits transsignaling responses
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January 2001 |
Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes
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March 1977 |
A hot spot of binding energy in a hormone-receptor interface
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January 1995 |
Molecular Description of Flexibility in an Antibody Combining Site
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May 2010 |
Comparison of simple potential functions for simulating liquid water
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July 1983 |
Re-epithelialization and immune cell behaviour in an ex vivo human skin model
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January 2020 |
The fundamental role of flexibility on the strength of molecular binding
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January 2012 |
Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis
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July 2007 |
Constant pressure molecular dynamics simulation: The Langevin piston method
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September 1995 |
The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.
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April 1996 |
Conformational Flexibility of the MHC Class I α1-α2 Domain in Peptide Bound and Free States: A Molecular Dynamics Simulation Study
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October 2004 |
gp 130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES
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April 1997 |
Sarilumab Plus Methotrexate in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate: Results of a Phase III Study
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May 2015 |
1.9 Acrystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling
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March 1997 |
Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.
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April 1993 |
Involvement of the Arg179 in the active site of human IL-6
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February 1993 |
CHARMM-GUI: A web-based graphical user interface for CHARMM
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March 2008 |
Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial
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March 2008 |
Structure-activity relationship study of human interleukin-3: role of the C-terminal region for biological activity.
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August 1991 |
Hepcidin regulation in the anemia of inflammation
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January 2016 |
The pro- and anti-inflammatory properties of the cytokine interleukin-6
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May 2011 |
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway1
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September 1998 |
Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems
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June 1993 |
Interleukin-6 in Aging and Chronic Disease: A Magnificent Pathway
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June 2006 |
Analysis of Inflammatory and Anemia-Related Biomarkers in a Randomized, Double-Blind, Placebo-Controlled Study of Siltuximab (Anti-IL6 Monoclonal Antibody) in Patients With Multicentric Castleman Disease
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June 2015 |
Interleukin-6 biology is coordinated by membrane bound and soluble receptors.
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September 2003 |
Analysis of the Human Interleukin-6/Human Interleukin-6 Receptor Binding Interface at the Amino Acid Level: Proposed Mechanism of Interaction
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February 1997 |
High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis
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June 1989 |
Hexameric Structure and Assembly of the Interleukin-6/IL-6 -Receptor/gp130 Complex
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June 2003 |
Direct Determination of Vibrational Density of States Change on Ligand Binding to a Protein
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July 2004 |
Interleukin-6 family of cytokines and gp130
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journal
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August 1995 |
Molecular Dynamics Simulations Reveal Key Roles of the Interleukin-6 Alpha Receptor in the Assembly of the Human Interleukin-6 Receptor Complex
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August 2017 |
Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies
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February 2018 |
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor
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August 1988 |
Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study
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March 2009 |
Considering new lessons about the use of IL-6 inhibitors in arthritis
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November 2018 |
Redistribution of Flexibility in Stabilizing Antibody Fragment Mutants Follows Le Châtelier’s Principle
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March 2014 |
Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial
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March 2008 |
Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints
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October 2013 |
Evidence for the importance of a positive charge and an α-helical structure of the C-terminus for biological activity of human IL-6
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May 1991 |
VMD: Visual molecular dynamics
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February 1996 |
Rational design of a receptor super-antagonist of human interleukin-6.
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December 1994 |