Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

Yuan, Meng; Huang, Deli; Lee, Chang-Chun D.; Wu, Nicholas C.; Jackson, Abigail M.; Zhu, Xueyong; Liu, Hejun; Peng, Linghang; van Gils, Marit J.; Sanders, Rogier W.; Burton, Dennis R.; Reincke, S. Momsen; Prüss, Harald; Kreye, Jakob; Nemazee, David; Ward, Andrew B.; Wilson, Ian A.

doi:10.1126/science.abh1139

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

Journal Article · Fri Aug 13 00:00:00 EDT 2021 · Science

DOI:https://doi.org/10.1126/science.abh1139· OSTI ID:1784370

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Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam, Netherlands.
Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam, Netherlands., Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.
Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Ragon Institute of MGH, Harvard, and MIT, Cambridge, MA 02139, USA.
German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany., Department of Neurology and Experimental Neurology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Berlin, Germany.
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Defenses against SARS-CoV-2 variants

Our key defense against the COVID-19 pandemic is neutralizing antibodies against the SARS-CoV-2 virus elicited by natural infection or vaccination. Recent emerging viral variants have raised concern because of their potential to escape antibody neutralization. Wang et al . identified four antibodies from early-outbreak convalescent donors that are potent against 23 variants, including variants of concern, and characterized their binding to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Yuan et al . examined the impact of emerging mutations in the receptor-binding domain of the spike protein on binding to the host receptor ACE2 and to a range of antibodies. These studies may be helpful for developing more broadly effective vaccines and therapeutic antibodies. —VV

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1784370

Alternate ID(s):: OSTI ID: 1816279
OSTI ID: 1831202
OSTI ID: 1832585

Journal Information:: Science, Journal Name: Science Journal Issue: 6556 Vol. 373; ISSN 0036-8075

Publisher:: American Association for the Advancement of Science (AAAS)Copyright Statement

Country of Publication:: United States

Language:: English

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