PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Ebola Virus Infection, Processed Experimental Dataset Catalog

Dataset · Mon Jan 18 00:00:00 EST 2021

DOI:https://doi.org/10.25584/LHVEBOV/1784282· OSTI ID:1784282

Anderson, Lindsey N.  ^[1]; Eisfeld, Amie J.  ^[2]; Waters, Katrina M.  ^[1]

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1. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
2. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department

Ebola virus (EBOV) is high risk biological agent, classified as a Category A priority pathogen (Flaviviridae) by the National Institute of Allergy and Infectious Diseases (NIAID), known to cause hemorrhagic fever with high mortality rates in humans. Lethal host-pathogen invasion mechanisms and the cellular intricacies behind these fatal infections still remain unclear. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-pathogen viral dataset downloads contain one or more statistically processed (normalization data transformation)  quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics (P), metabolomics (M), lipidomics (L), and transcriptomics (T) dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific Ebola virus [NCBITAXON:186536] (Zaire/Makona or Zaire/Mayinga) experimental infection study. Human host samples types include peripheral blood mononuclear cells isolated from blood plasma ["PBMC", BTO:0001025], human hepatoma carcinoma cells ["HUH", BTO:0001950], human umbilical vein endothelial cells ["HUVEC", BTO:0001949], immortalized human hepatocyte cells ["IHH", BTO:0006147], and human histiocytic lymphoma cells ["U937", BTO:0001412]. 

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
• Contributing Organization: Modeling Host Responses to Understand Severe Human Virus Infections Program Project
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1784282
• Report Number(s): LHVEBOV; EH001; EHUH001; EHUH002; EHUH003; EHUVEC001; EIHH001; EIHH002; EU937001
• Availability: [e-mail]
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Virology [edam.topic:0781]
Immune Response [GO:0006955]
Human virus [NCIT:C14317]
Ebolavirus [NCBITAXON:186536]
Time Sampled Measurement Datasets [IAO:0000584]
Mass spectrometry data [edam.data:2536]
MassIVE dataset identifier [MS:1002487]
Gene expression profile data [edam.data:0928]
BioProject Accession Number [NCIT:C175890]
Omics [edam.topic:3391]
Multi-omics [edam.topic:4021]
data transformation [SIO:000594]
differential expression analysis [SWO:7000018]
Dataset Collection [schema:DataCatalog]