Engineering the atomic structure of sequence-defined peptoid polymers and their assemblies

Xuan, Sunting; Zuckermann, Ronald N.

doi:10.1016/j.polymer.2020.122691

Title: Engineering the atomic structure of sequence-defined peptoid polymers and their assemblies

Journal Article · Sat Jun 06 00:00:00 EDT 2020 · Polymer

DOI:https://doi.org/10.1016/j.polymer.2020.122691· OSTI ID:1782161

Xuan, Sunting ^[1]; Zuckermann, Ronald N. ^[1]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Peptoids are a family of sequence-defined, non-natural biomimetic polymers which show excellent properties including good chemical and enzymatic stability and high structural tunability. The solid-phase submonomer synthesis method allows precise control over the identity and sequence of chemically diverse side chains, enabling the atomic engineering of their chemical structures for a variety of applications. This unprecedented level of structural control enables access to atomically defined three-dimensional chain conformations and assemblies, facilitating the design and optimization of a variety of nanoscale architectures that can function in biology and materials science. In order to approach the rational design of peptoid materials in a more predictive and precise manner, it is crucial to fully understand how chemical information, in the form of the monomer sequence, encodes their folding and assembly into structurally defined, functional 3D shapes. Furthermore, this perspective focuses on recent studies into the atomic engineering of peptoid nanostructures by examining the impact of sequence variations on their secondary and three-dimensional structures, as well as their functional properties.

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Research Organization:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1782161

Alternate ID(s):: OSTI ID: 1633397

Journal Information:: Polymer, Vol. 202; ISSN 0032-3861

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Sequence-defined polymers
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Title: Engineering the atomic structure of sequence-defined peptoid polymers and their assemblies

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