An Integrated Design of a Polypseudorotaxane-Based Sea Cucumber Mimic

Li, Longyu; Lin, Qianming; Tang, Miao; Tsai, Esther R.; Ke, Chenfeng

doi:10.1002/anie.202017019

An Integrated Design of a Polypseudorotaxane-Based Sea Cucumber Mimic

Journal Article · Fri Feb 19 00:00:00 EST 2021 · Angewandte Chemie (International Edition)

DOI:https://doi.org/10.1002/anie.202017019· OSTI ID:1776536

^[1]; Lin, Qianming ^[1]; Tang, Miao ^[1]; ^[2]; ^[1]

Dartmouth College, Hanover, NH (United States)
Brookhaven National Lab. (BNL), Upton, NY (United States)

The development of integrated systems that mimic the multi-stage stiffness change of marine animals such as the sea cucumber requires the design of molecularly tailored structures. Herein, we used an integrated biomimicry design to fabricate a sea cucumber mimic using sidechain polypseudorotaxanes with tunable nano-to-macroscale properties. A series of polyethylene glycol (PEG)-based sidechain copolymers were synthesized to form sidechain polypseudorotaxanes with α-cyclodextrins (α-CDs). By tailoring the copolymers’ molecular weights and their PEG grafting densities, we rationally tuned the sizes of the formed polypseudorotaxanes crystalline domain and the physical crosslinking density of the hydrogels, which facilitated 3D printing and the mechanical adaptability to these hydrogels. After 3D printing and photo-crosslinking, the obtained hydrogels exhibited large tensile strain and broad elastic-to-plastic variations upon α-CD (de)threading. Finally, these discoveries enabled a successful fabrication of a sea cucumber mimic, demonstrating multi-stage stiffness changes.

View Accepted Manuscript (DOE)

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: National Science Foundation (NSF); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0012704

OSTI ID:: 1776536

Report Number(s):: BNL--221230-2021-JAAM

Journal Information:: Angewandte Chemie (International Edition), Journal Name: Angewandte Chemie (International Edition) Journal Issue: 18 Vol. 60; ISSN 1433-7851

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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36 MATERIALS SCIENCE
3D printing
biomimicry
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polypseudorotaxane
slide-ring gels

An Integrated Design of a Polypseudorotaxane-Based Sea Cucumber Mimic

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