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Evaluation of fosphenytoin, levetiracetam, and propofol as treatments for nerve agent-induced seizures in pediatric and adult rats

Journal Article · · Neurotoxicology
Not Available
Sponsoring Organization:
USDOE
OSTI ID:
1776413
Journal Information:
Neurotoxicology, Journal Name: Neurotoxicology Journal Issue: C Vol. 79; ISSN 0161-813X
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (34)

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Propofol Use for Toxin-Related Seizures
  • Cantrell, F. Lee; Wardi, Gabriel; O'Connell, Charles
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Control of nerve agent-induced seizures is critical for neuroprotection and survival☆ ☆The animals used in these studies were handled in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals, proposed by the Committee to Revise the Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources, National Research Council, and published by National Academy Press, 1996, and the Animal Welfare Act of 1966, as amended. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as reflecting the views of the Department of the Army or the Department of Defense. journal April 2003
Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial journal May 2019
Neuropharmacological Mechanisms of Nerve Agent-induced Seizure and Neuropathology 1 1The animals used in studies performed in, or sponsored by, this Institute were handled in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals, proposed by the Committee on Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources, National Research Council, DHHA, National Institute of Health Publication #85–23, 1985, and the Animal Welfare Act of 1966, as amended. The opinions, or assertions contained herein are the private views of the authors, and are not to be construed as reflecting the views of the Department of the Army or the Department of Defense. journal January 1997
Preparation for Terrorist Threats: Biologic and Chemical Agents journal September 2009
Organophosphate and Carbamate Poisoning journal February 2015
Age-dependent behaviors, seizure severity and neuronal damage in response to nerve agents or the organophosphate DFP in immature and adult rats journal May 2018
Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats journal September 2019
Intravenous levetiracetam in the rat pilocarpine-induced status epilepticus model: Behavioral, physiological and histological studies journal March 2010
Intravenous levetiracetam: Treatment experience with the first 50 critically ill patients journal April 2008
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus journal November 2019
Levetiracetam in toxic seizures journal July 2017
Effects of Fosphenytoin on Nerve Agent‐Induced Status epilepticus journal November 2004
The intensive care treatment of convulsive status epilepticus in the UK.: Results of a national survey and recommendations journal February 1995
Treatment of Refractory Status Epilepticus with Propofol: Clinical and Pharmacokinetic Findings journal January 1998
Neuroprotective Effects of Diazepam, Carbamazepine, Phenytoin and Ketamine after Pilocarpine-induced Status Epilepticus journal June 2009
Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents: Models of chemical-induced seizures journal July 2016
Managing status epilepticus journal April 2000
Rapid Infusion of a Loading Dose of Intravenous Levetiracetam With Minimal Dilution: A Safety Study journal March 2009
Propofol and barbiturates for the anesthesia of refractory convulsive status epilepticus: pros and cons journal October 2007
Nerve Agent Attacks on Children: Diagnosis and Management journal August 2003
Prehospital Preparedness for Pediatric Mass-Casualty Events journal October 2007
Time-dependent reduction in the anticonvulsant effectiveness of diazepam against soman-induced seizures in guinea pigs journal April 2010
Clinical Pharmacology and Pharmacokinetics of Levetiracetam journal January 2013
Mechanisms of Levetiracetam in the Control of Status Epilepticus and Epilepsy journal January 2014
Disaster preparedness, pediatric considerations in primary blast injury, chemical, and biological terrorism journal January 2014
Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society journal January 2016

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