Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease

Agudelo, Marianna; Palus, Martin; Keeffe, Jennifer R.; Bianchini, Filippo; Svoboda, Pavel; Salát, Jiří; Peace, Avery; Gazumyan, Anna; Cipolla, Melissa; Kapoor, Tania; Guidetti, Francesca; Yao, Kai-Hui; Elsterová, Jana; Teislerová, Dana; Chrdle, Aleš; Hönig, Václav; Oliveira, Thiago; West, Jr., Anthony P.; Lee, Yu E.; Rice, Charles M.; MacDonald, Margaret R.; Bjorkman, Pamela J.; Růžek, Daniel; Robbiani, Davide F.; Nussenzweig, Michel C.

doi:10.1084/jem.20210236

Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease

Journal Article · Thu Apr 08 00:00:00 EDT 2021 · Journal of Experimental Medicine

DOI:https://doi.org/10.1084/jem.20210236· OSTI ID:1775151

; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; more »

Tick-borne encephalitis virus (TBEV) is an emerging human pathogen that causes potentially fatal disease with no specific treatment. Mouse monoclonal antibodies are protective against TBEV, but little is known about the human antibody response to infection. Here, we report on the human neutralizing antibody response to TBEV in a cohort of infected and vaccinated individuals. Expanded clones of memory B cells expressed closely related anti-envelope domain III (EDIII) antibodies in both groups of volunteers. However, the most potent neutralizing antibodies, with IC50s below 1 ng/ml, were found only in individuals who recovered from natural infection. These antibodies also neutralized other tick-borne flaviviruses, including Langat, louping ill, Omsk hemorrhagic fever, Kyasanur forest disease, and Powassan viruses. Structural analysis revealed a conserved epitope near the lateral ridge of EDIII adjoining the EDI–EDIII hinge region. Prophylactic or early therapeutic antibody administration was effective at low doses in mice that were lethally infected with TBEV.

View Journal Article

Sponsoring Organization:: USDOE

OSTI ID:: 1775151

Alternate ID(s):: OSTI ID: 1816733

Journal Information:: Journal of Experimental Medicine, Journal Name: Journal of Experimental Medicine Journal Issue: 5 Vol. 218; ISSN 0022-1007

Publisher:: Rockefeller University PressCopyright Statement

Country of Publication:: United States

Language:: English

References (91)

Ability of inactivated vaccines based on far‐eastern tick‐borne encephalitis virus strains to induce humoral immune response in originally seropositive and seronegative recipients Maikova, Galina B.; Chernokhaeva, Liubov L.; Rogova, Yulia V. Journal of Medical Virology, Vol. 91, Issue 2 https://doi.org/10.1002/jmv.25316	journal	October 2018
Severe tick-borne encephalitis following passive immunization Waldvogel, K.; Bossart, W.; Huisman, T. European Journal of Pediatrics, Vol. 155, Issue 9 https://doi.org/10.1007/BF02002905	journal	September 1996
A simple method for displaying the hydropathic character of a protein Kyte, Jack; Doolittle, Russell F. Journal of Molecular Biology, Vol. 157, Issue 1, p. 105-132 https://doi.org/10.1016/0022-2836(82)90515-0	journal	May 1982
Antibodies against tick-borne encephalitis virus (TBEV) non-structural and structural proteins in human sera and spinal fluid Matveeva, V. A.; Popova, R. V.; Kvetkova, E. A. Immunology Letters, Vol. 46, Issue 1-2 https://doi.org/10.1016/0165-2478(95)00021-V	journal	May 1995
Amino acid side-chain partition energies and distribution of residues in soluble proteins Guy, H. R. Biophysical Journal, Vol. 47, Issue 1 https://doi.org/10.1016/S0006-3495(85)83877-7	journal	January 1985
Pathogenic flaviviruses Gould, Ea; Solomon, T. The Lancet, Vol. 371, Issue 9611 https://doi.org/10.1016/S0140-6736(08)60238-X	journal	February 2008
Tickborne encephalitis despite specific immunoglobulin prophylaxis Kluger, G.; Schöttler, A.; Waldvogel, K. The Lancet, Vol. 346, Issue 8988 https://doi.org/10.1016/S0140-6736(95)92527-9	journal	December 1995
Do specific hyperimmunoglobulins aggravate clinical course of tick-borne encephalitis? Arras, C.; Fescharek, R.; Gregersen, J. P. The Lancet, Vol. 347, Issue 9011 https://doi.org/10.1016/S0140-6736(96)90977-0	journal	May 1996
Diagnosis of tick-borne encephalitis Holzmann, Heidemarie Vaccine, Vol. 21 https://doi.org/10.1016/S0264-410X(02)00819-8	journal	April 2003
A tick-borne encephalitis ceiling in Central Europe has moved upwards during the last 30 years: Possible impact of global warming? Zeman, Petr; Beneš, Cestmir International Journal of Medical Microbiology Supplements, Vol. 293 https://doi.org/10.1016/S1433-1128(04)80008-1	journal	April 2004
Tick-borne encephalitis in Europe and Russia: Review of pathogenesis, clinical features, therapy, and vaccines Ruzek, Daniel; Avšič Županc, Tatjana; Borde, Johannes Antiviral Research, Vol. 164 https://doi.org/10.1016/j.antiviral.2019.01.014	journal	April 2019
Antigen–antibody interface properties: Composition, residue interactions, and features of 53 non-redundant structures Ramaraj, Thiruvarangan; Angel, Thomas; Dratz, Edward A. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1824, Issue 3 https://doi.org/10.1016/j.bbapap.2011.12.007	journal	March 2012
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico Robbiani, Davide F.; Bozzacco, Leonia; Keeffe, Jennifer R. Cell, Vol. 169, Issue 4 https://doi.org/10.1016/j.cell.2017.04.024	journal	May 2017
Emerging Pandemic Diseases: How We Got to COVID-19 Morens, David M.; Fauci, Anthony S. Cell, Vol. 182, Issue 5 https://doi.org/10.1016/j.cell.2020.08.021	journal	September 2020
A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates Keeffe, Jennifer R.; Van Rompay, Koen K. A.; Olsen, Priscilla C. Cell Reports, Vol. 25, Issue 6 https://doi.org/10.1016/j.celrep.2018.10.031	journal	November 2018
Structural Insights into the Mechanisms of Antibody-Mediated Neutralization of Flavivirus Infection: Implications for Vaccine Development Pierson, Theodore C.; Fremont, Daved H.; Kuhn, Richard J. Cell Host & Microbe, Vol. 4, Issue 3 https://doi.org/10.1016/j.chom.2008.08.004	journal	September 2008
The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity Beltramello, Martina; Williams, Katherine L.; Simmons, Cameron P. Cell Host & Microbe, Vol. 8, Issue 3 https://doi.org/10.1016/j.chom.2010.08.007	journal	September 2010
A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations Wang, Qiao; Michailidis, Eleftherios; Yu, Yingpu Cell Host & Microbe, Vol. 28, Issue 2 https://doi.org/10.1016/j.chom.2020.05.010	journal	August 2020
Tick-Borne Flaviviruses LaSala, P. Rocco; Holbrook, Michael Clinics in Laboratory Medicine, Vol. 30, Issue 1 https://doi.org/10.1016/j.cll.2010.01.002	journal	March 2010
Tick-borne encephalitis virus vaccination breakthrough infections in Germany: a retrospective analysis from 2001 to 2018 Dobler, G.; Kaier, K.; Hehn, P. Clinical Microbiology and Infection, Vol. 26, Issue 8 https://doi.org/10.1016/j.cmi.2019.12.001	journal	August 2020
VH1-69 antiviral broadly neutralizing antibodies: genetics, structures, and relevance to rational vaccine design Chen, Fang; Tzarum, Netanel; Wilson, Ian A. Current Opinion in Virology, Vol. 34 https://doi.org/10.1016/j.coviro.2019.02.004	journal	February 2019
Tick-Borne Encephalitis Kaiser, Reinhard Infectious Disease Clinics of North America, Vol. 22, Issue 3 https://doi.org/10.1016/j.idc.2008.03.013	journal	September 2008
TBE incidence versus virus prevalence and increased prevalence of the TBE virus in Ixodes ricinus removed from humans Süss, Jochen; Klaus, Christine; Diller, Roland International Journal of Medical Microbiology, Vol. 296 https://doi.org/10.1016/j.ijmm.2005.12.005	journal	May 2006
Autoreactivity in Human IgG+ Memory B Cells Tiller, Thomas; Tsuiji, Makoto; Yurasov, Sergey Immunity, Vol. 26, Issue 2 https://doi.org/10.1016/j.immuni.2007.01.009	journal	February 2007
Inference of Macromolecular Assemblies from Crystalline State Krissinel, Evgeny; Henrick, Kim Journal of Molecular Biology, Vol. 372, Issue 3 https://doi.org/10.1016/j.jmb.2007.05.022	journal	September 2007
Factors associated with severity of tick-borne encephalitis: A prospective observational study Bogovič, Petra; Lotrič-Furlan, Stanka; Avšič-Županc, Tatjana Travel Medicine and Infectious Disease, Vol. 26 https://doi.org/10.1016/j.tmaid.2018.10.003	journal	November 2018
Seroprevalence of Borrelia burgdorferi sensu lato and tick-borne encephalitis virus in zoo animal species in the Czech Republic Širmarová, Jana; Tichá, Lucie; Golovchenko, Marina Ticks and Tick-borne Diseases, Vol. 5, Issue 5 https://doi.org/10.1016/j.ttbdis.2014.03.008	journal	September 2014
The long-term outcome of tick-borne encephalitis in Central Europe Bogovič, Petra; Stupica, Daša; Rojko, Tereza Ticks and Tick-borne Diseases, Vol. 9, Issue 2 https://doi.org/10.1016/j.ttbdis.2017.12.001	journal	February 2018
Chimeric antibodies against tick-borne encephalitis virus Levanov, Lev N.; Matveev, Leonid E.; Goncharova, Elena P. Vaccine, Vol. 28, Issue 32 https://doi.org/10.1016/j.vaccine.2010.05.060	journal	July 2010
The current perspective on tick-borne encephalitis awareness and prevention in six Central and Eastern European countries: Report from a meeting of experts convened to discuss TBE in their region Kollaritsch, Herwig; Chmelík, Václav; Dontsenko, Irina Vaccine, Vol. 29, Issue 28 https://doi.org/10.1016/j.vaccine.2011.04.061	journal	June 2011
A protective chimeric antibody to tick-borne encephalitis virus Baykov, Ivan K.; Matveev, Andrey L.; Stronin, Oleg V. Vaccine, Vol. 32, Issue 29 https://doi.org/10.1016/j.vaccine.2014.05.012	journal	June 2014
Characterization of neutralizing monoclonal antibody against tick-borne encephalitis virus in vivo Matveev, Andrey; Matveev, Leonid; Stronin, Oleg Vaccine, Vol. 38, Issue 27 https://doi.org/10.1016/j.vaccine.2020.04.051	journal	June 2020
A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection Pierson, Theodore C.; Sánchez, Melissa D.; Puffer, Bridget A. Virology, Vol. 346, Issue 1 https://doi.org/10.1016/j.virol.2005.10.030	journal	March 2006
Dengue virus neutralization by human immune sera: Role of envelope protein domain III-reactive antibody Wahala, W. M. P. B.; Kraus, Annette A.; Haymore, Laura B. Virology, Vol. 392, Issue 1 https://doi.org/10.1016/j.virol.2009.06.037	journal	September 2009
The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution Rey, Félix A.; Heinz, Franz X.; Mandl, Christian Nature, Vol. 375, Issue 6529 https://doi.org/10.1038/375291a0	journal	May 1995
Structural basis of West Nile virus neutralization by a therapeutic antibody Nybakken, Grant E.; Oliphant, Theodore; Johnson, Syd Nature, Vol. 437, Issue 7059 https://doi.org/10.1038/nature03956	journal	September 2005
Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice Sapparapu, Gopal; Fernandez, Estefania; Kose, Nurgun Nature, Vol. 540, Issue 7633 https://doi.org/10.1038/nature20564	journal	November 2016
New insights into the immunopathology and control of dengue virus infection Screaton, Gavin; Mongkolsapaya, Juthathip; Yacoub, Sophie Nature Reviews Immunology, Vol. 15, Issue 12 https://doi.org/10.1038/nri3916	journal	November 2015
Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody Füzik, Tibor; Formanová, Petra; Růžek, Daniel Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-02882-0	journal	January 2018
A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus Xu, Meihui; Zuest, Roland; Velumani, Sumathy npj Vaccines, Vol. 2, Issue 1 https://doi.org/10.1038/s41541-016-0003-3	journal	January 2017
Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection McAuley, Alexander J.; Sawatsky, Bevan; Ksiazek, Thomas npj Vaccines, Vol. 2, Issue 1 https://doi.org/10.1038/s41541-017-0009-5	journal	March 2017
Commonality despite exceptional diversity in the baseline human antibody repertoire Briney, Bryan; Inderbitzin, Anne; Joyce, Collin Nature, Vol. 566, Issue 7744 https://doi.org/10.1038/s41586-019-0879-y	journal	January 2019
Convergent antibody responses to SARS-CoV-2 in convalescent individuals Robbiani, Davide F.; Gaebler, Christian; Muecksch, Frauke Nature, Vol. 584, Issue 7821 https://doi.org/10.1038/s41586-020-2456-9	journal	June 2020
Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus Renner, Max; Flanagan, Aleksandra; Dejnirattisai, Wanwisa Nature Immunology, Vol. 19, Issue 11 https://doi.org/10.1038/s41590-018-0227-7	journal	October 2018
Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120 West, Anthony P.; Diskin, Ron; Nussenzweig, Michel C. Proceedings of the National Academy of Sciences, Vol. 109, Issue 30 https://doi.org/10.1073/pnas.1208984109	journal	June 2012
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies Mouquet, H.; Scharf, L.; Euler, Z. Proceedings of the National Academy of Sciences, Vol. 109, Issue 47 https://doi.org/10.1073/pnas.1217207109	journal	October 2012
Computational analysis of anti-HIV-1 antibody neutralization panel data to identify potential functional epitope residues West, A. P.; Scharf, L.; Horwitz, J. Proceedings of the National Academy of Sciences, Vol. 110, Issue 26 https://doi.org/10.1073/pnas.1309215110	journal	June 2013
Recent establishment of tick-borne encephalitis foci with distinct viral lineages in the Helsinki area, Finland Smura, Teemu; Tonteri, Elina; Jääskeläinen, Anu Emerging Microbes & Infections, Vol. 8, Issue 1 https://doi.org/10.1080/22221751.2019.1612279	journal	January 2019
CDR3 length in antigen-specific immune receptors. Rock, E. P.; Sibbald, P. R.; Davis, M. M. Journal of Experimental Medicine, Vol. 179, Issue 1 https://doi.org/10.1084/jem.179.1.323	journal	January 1994
Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants Klein, Florian; Nogueira, Lilian; Nishimura, Yoshiaki The Journal of Experimental Medicine, Vol. 211, Issue 12 https://doi.org/10.1084/jem.20141050	journal	November 2014
Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge Zhao, Haiyan; Xu, Lily; Bombardi, Robin Journal of Experimental Medicine, Vol. 217, Issue 2 https://doi.org/10.1084/jem.20191792	journal	November 2019
Generation of a Lineage II Powassan Virus (Deer Tick Virus) cDNA Clone: Assessment of Flaviviral Genetic Determinants of Tick and Mosquito Vector Competence Kenney, Joan L.; Anishchenko, Michael; Hermance, Meghan Vector-Borne and Zoonotic Diseases, Vol. 18, Issue 7 https://doi.org/10.1089/vbz.2017.2224	journal	July 2018
Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data: Table 1. Gupta, Namita T.; Vander Heiden, Jason A.; Uduman, Mohamed Bioinformatics, Vol. 31, Issue 20 https://doi.org/10.1093/bioinformatics/btv359	journal	June 2015
Anti-tick-borne encephalitis (TBE) virus neutralizing antibodies dynamics in natural infections versus vaccination Remoli, Maria Elena; Marchi, Antonella; Fortuna, Claudia Pathogens and Disease, Vol. 73, Issue 2 https://doi.org/10.1093/femspd/ftu002	journal	December 2014
IgBLAST: an immunoglobulin variable domain sequence analysis tool Ye, Jian; Ma, Ning; Madden, Thomas L. Nucleic Acids Research, Vol. 41, Issue W1 https://doi.org/10.1093/nar/gkt382	journal	May 2013
Antibody-dependent Enhancement of Tick-borne Encephalitis Virus Infectivity Phillpotts, R. J.; Stephenson, J. R.; Porterfield, J. S. Journal of General Virology, Vol. 66, Issue 8 https://doi.org/10.1099/0022-1317-66-8-1831	journal	August 1985
Antigenic Relationships between Flaviviruses as Determined by Cross-neutralization Tests with Polyclonal Antisera Calisher, C. H.; Karabatsos, N.; Dalrymple, J. M. Journal of General Virology, Vol. 70, Issue 1 https://doi.org/10.1099/0022-1317-70-1-37	journal	January 1989
Flavivirus-induced antibody cross-reactivity Mansfield, Karen L.; Horton, Daniel L.; Johnson, Nicholas Journal of General Virology, Vol. 92, Issue 12 https://doi.org/10.1099/vir.0.031641-0	journal	December 2011
WebLogo: A Sequence Logo Generator Crooks, Gavin E.; Hon, Gary; Chandonia, John-Marc Genome Research, Vol. 14, Issue 6, p. 1188-1190 https://doi.org/10.1101/gr.849004	journal	May 2004
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
Overview of the CCP 4 suite and current developments Winn, Martyn D.; Ballard, Charles C.; Cowtan, Kevin D. Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4 https://doi.org/10.1107/S0907444910045749	journal	March 2011
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM Battye, T. Geoff G.; Kontogiannis, Luke; Johnson, Owen Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4 https://doi.org/10.1107/S0907444910048675	journal	March 2011
Tick-borne encephalitis in patients vaccinated against this disease Lotrič-Furlan, S.; Bogovič, P.; Avšič-Županc, T. Journal of Internal Medicine, Vol. 282, Issue 2 https://doi.org/10.1111/joim.12625	journal	May 2017
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding Scheid, J. F.; Mouquet, H.; Ueberheide, B. Science, Vol. 333, Issue 6049 https://doi.org/10.1126/science.1207227	journal	July 2011
Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection Stettler, K.; Beltramello, M.; Espinosa, D. A. Science, Vol. 353, Issue 6301 https://doi.org/10.1126/science.aaf8505	journal	July 2016
Tick-Borne Encephalitis Virus-Neutralizing Antibodies in Different Immunoglobulin Preparations Rabel, Philip O.; Planitzer, Christina B.; Farcet, Maria R. Clinical and Vaccine Immunology, Vol. 19, Issue 4 https://doi.org/10.1128/CVI.05705-11	journal	February 2012
Tick-Borne Encephalitis Virus Nonstructural Protein 1 IgG Enzyme-Linked Immunosorbent Assay for Differentiating Infection versus Vaccination Antibody Responses Girl, P.; Bestehorn-Willmann, M.; Zange, S. Journal of Clinical Microbiology, Vol. 58, Issue 4 https://doi.org/10.1128/JCM.01783-19	journal	January 2020
Antibodies to Envelope Glycoprotein of Dengue Virus during the Natural Course of Infection Are Predominantly Cross-Reactive and Recognize Epitopes Containing Highly Conserved Residues at the Fusion Loop of Domain II Lai, Chih-Yun; Tsai, Wen-Yang; Lin, Su-Ru Journal of Virology, Vol. 82, Issue 13 https://doi.org/10.1128/JVI.00316-08	journal	April 2008
Molecular Basis of a Protective/Neutralizing Monoclonal Antibody Targeting Envelope Proteins of both Tick-Borne Encephalitis Virus and Louping Ill Virus Yang, Xu; Qi, Jianxun; Peng, Ruchao Journal of Virology, Vol. 93, Issue 8 https://doi.org/10.1128/JVI.02132-18	journal	February 2019
Phylogeny of the Genus Flavivirus Kuno, Goro; Chang, Gwong-Jen J.; Tsuchiya, K. Richard Journal of Virology, Vol. 72, Issue 1 https://doi.org/10.1128/JVI.72.1.73-83.1998	journal	January 1998
Neutralizing Antibodies Protect against Lethal Flavivirus Challenge but Allow for the Development of Active Humoral Immunity to a Nonstructural Virus Protein Kreil, Thomas R.; Maier, Elisabeth; Fraiss, Sabine Journal of Virology, Vol. 72, Issue 4 https://doi.org/10.1128/JVI.72.4.3076-3081.1998	journal	April 1998
Monoclonal Antibodies That Bind to Domain III of Dengue Virus E Glycoprotein Are the Most Efficient Blockers of Virus Adsorption to Vero Cells Crill, Wayne D.; Roehrig, John T. Journal of Virology, Vol. 75, Issue 16 https://doi.org/10.1128/JVI.75.16.7769-7773.2001	journal	August 2001
Identification of Neutralizing Epitopes within Structural Domain III of the West Nile Virus Envelope Protein Beasley, David W. C.; Barrett, Alan D. T. Journal of Virology, Vol. 76, Issue 24 https://doi.org/10.1128/JVI.76.24.13097-13100.2002	journal	December 2002
Dengue Antibody-Dependent Enhancement: Knowns and Unknowns Halstead, Scott B. Microbiology Spectrum, Vol. 2, Issue 6 https://doi.org/10.1128/microbiolspec.AID-0022-2014	journal	November 2014
Comparison of the Immunogenicity and Safety of Two Pediatric TBE Vaccines Based on the Far Eastern and European Virus Subtypes Vorovitch, Mikhail F.; Maikova, Galina B.; Chernokhaeva, Liubov L. Advances in Virology, Vol. 2019 https://doi.org/10.1155/2019/5323428	journal	December 2019
Changes in cytokine and chemokine profiles in mouse serum and brain, and in human neural cells, upon tick-borne encephalitis virus infection Pokorna Formanova, Petra; Palus, Martin; Salat, Jiri Journal of Neuroinflammation, Vol. 16, Issue 1 https://doi.org/10.1186/s12974-019-1596-z	journal	November 2019
Epidemiology and pathological mechanisms of tick-borne encephalitis Yoshii, Kentaro Journal of Veterinary Medical Science, Vol. 81, Issue 3 https://doi.org/10.1292/jvms.18-0373	journal	January 2019
Tick-borne encephalitis: A review of epidemiology, clinical characteristics, and management Bogovic, Petra World Journal of Clinical Cases, Vol. 3, Issue 5 https://doi.org/10.12998/wjcc.v3.i5.430	journal	January 2015
Onset of Immune Senescence Defined by Unbiased Pyrosequencing of Human Immunoglobulin mRNA Repertoires Rubelt, Florian; Sievert, Volker; Knaust, Florian PLoS ONE, Vol. 7, Issue 11 https://doi.org/10.1371/journal.pone.0049774	journal	November 2012
A Public Database of Memory and Naive B-Cell Receptor Sequences DeWitt, William S.; Lindau, Paul; Snyder, Thomas M. PLOS ONE, Vol. 11, Issue 8 https://doi.org/10.1371/journal.pone.0160853	journal	August 2016
A Therapeutic Antibody against West Nile Virus Neutralizes Infection by Blocking Fusion within Endosomes Thompson, Bruce S.; Moesker, Bastiaan; Smit, Jolanda M. PLoS Pathogens, Vol. 5, Issue 5 https://doi.org/10.1371/journal.ppat.1000453	journal	May 2009
Potent Dengue Virus Neutralization by a Therapeutic Antibody with Low Monovalent Affinity Requires Bivalent Engagement Edeling, Melissa A.; Austin, S. Kyle; Shrestha, Bimmi PLoS Pathogens, Vol. 10, Issue 4 https://doi.org/10.1371/journal.ppat.1004072	journal	April 2014
Distinction between serological responses following tick-borne encephalitis virus (TBEV) infection vs vaccination, Sweden 2017 Albinsson, Bo; Vene, Sirkka; Rombo, Lars Eurosurveillance, Vol. 23, Issue 3 https://doi.org/10.2807/1560-7917.ES.2018.23.3.17-00838	journal	January 2018
Tick-borne encephalitis in Europe, 2012 to 2016 Beauté, Julien; Spiteri, Gianfranco; Warns-Petit, Eva Eurosurveillance, Vol. 23, Issue 45 https://doi.org/10.2807/1560-7917.ES.2018.23.45.1800201	journal	November 2018
Tick-borne encephalitis transmitted by unpasteurised cow milk in western Hungary, September to October 2011 Caini, S.; Szomor, K.; Ferenczi, E. Eurosurveillance, Vol. 17, Issue 12 https://doi.org/10.2807/ese.17.12.20128-en	journal	March 2012
Tick-borne Encephalitis from Eating Goat Cheese in a Mountain Region of Austria Holzmann, Heidemarie; Aberle, Stephan W.; Stiasny, Karin Emerging Infectious Diseases, Vol. 15, Issue 10 https://doi.org/10.3201/eid1510.090743	journal	October 2009
Development of Antibody Therapeutics against Flaviviruses Sun, Haiyan; Chen, Qiang; Lai, Huafang International Journal of Molecular Sciences, Vol. 19, Issue 1 https://doi.org/10.3390/ijms19010054	journal	December 2017
Tick-Borne Encephalitis Virus: A Structural View Pulkkinen, Lauri; Butcher, Sarah; Anastasina, Maria Viruses, Vol. 10, Issue 7 https://doi.org/10.3390/v10070350	journal	June 2018
Seropersistence of tick-borne encephalitis antibodies, safety and booster response to FSME-IMMUN ^® 0.5 ml in adults aged 18-67 years Loew-Baselli, Alexandra; Poellabauer, Eva-Maria; Pavlova, Borislava G. Human Vaccines, Vol. 5, Issue 8 https://doi.org/10.4161/hv.5.8.8571	journal	August 2009

Similar Records

Inhibition of tick-borne encephalitis virus in cell cultures by ribavirin

Journal Article · Mon Jun 12 00:00:00 EDT 2023 · Frontiers in Microbiology · OSTI ID:1984569

Characterization of a novel insect-specific flavivirus from Brazil: Potential for inhibition of infection of arthropod cells with medically important flaviviruses.

Journal Article · Sat Jan 11 23:00:00 EST 2014 · Journal of General Virology · OSTI ID:1185007

Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease

Citation Formats

References (91)

Similar Records

Related Subjects