In vivo biosensors: mechanisms, development, and applications

Shi, Shuobo; Ang, Ee Lui; Zhao, Huimin

doi:10.1007/s10295-018-2004-x

Title: In vivo biosensors: mechanisms, development, and applications

Journal Article · Sun Jul 01 00:00:00 EDT 2018 · Journal of Industrial Microbiology and Biotechnology

DOI:https://doi.org/10.1007/s10295-018-2004-x· OSTI ID:1773513

Shi, Shuobo ^[1]; Ang, Ee Lui ^[2]; Zhao, Huimin ^[3]

0000 0004 0637 0221 grid.185448.4 Metabolic Engineering Research Laboratory, Science and Engineering Institutes Agency for Science, Technology and Research Singapore Singapore, 0000 0000 9931 8406 grid.48166.3d Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing People’s Republic of China
0000 0004 0637 0221 grid.185448.4 Metabolic Engineering Research Laboratory, Science and Engineering Institutes Agency for Science, Technology and Research Singapore Singapore
0000 0004 0637 0221 grid.185448.4 Metabolic Engineering Research Laboratory, Science and Engineering Institutes Agency for Science, Technology and Research Singapore Singapore, 0000 0000 9931 8406 grid.48166.3d Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing People’s Republic of China, 0000 0004 1936 9991 grid.35403.31 Department of Chemical and Biomolecular Engineering University of Illinois at Urbana-Champaign Urbana IL USA

Abstract In vivo biosensors can recognize and respond to specific cellular stimuli. In recent years, biosensors have been increasingly used in metabolic engineering and synthetic biology, because they can be implemented in synthetic circuits to control the expression of reporter genes in response to specific cellular stimuli, such as a certain metabolite or a change in pH. There are many types of natural sensing devices, which can be generally divided into two main categories: protein-based and nucleic acid-based. Both can be obtained either by directly mining from natural genetic components or by engineering the existing genetic components for novel specificity or improved characteristics. A wide range of new technologies have enabled rapid engineering and discovery of new biosensors, which are paving the way for a new era of biotechnological progress. Here, we review recent advances in the design, optimization, and applications of in vivo biosensors in the field of metabolic engineering and synthetic biology.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0018260

OSTI ID:: 1773513

Journal Information:: Journal of Industrial Microbiology and Biotechnology, Journal Name: Journal of Industrial Microbiology and Biotechnology Vol. 45 Journal Issue: 7; ISSN 1367-5435

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: Germany

Language:: English

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Cited by: 34 works

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