PNNL DataHub Project: Omics Lethal Human Viruses Project Profiling of the Host Response to Influenza A Virus Infection, Processed Experimental Dataset Catalog

Dataset · Mon Jan 18 00:00:00 EST 2021

DOI:https://doi.org/10.25584/LHVFLU/1773428· OSTI ID:1773428

Anderson, Lindsey N.  ^[1]; Eisfeld, Amie J.  ^[2]; Waters, Katrina M.  ^[1]

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1. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
2. Univ. of Wisconsin, Madison, WI (United States). School of Veterinary Medicine. Pathology Department

Influenza A virus (IAV) is a high risk biological agent, classified as a Category C priority pathogen (Orthomyxoviridae) by the National Institute of Allergy and Infectious Diseases (NIAID), and is known to cause severe respiratory disease with high mortality rates in humans. Lethal host-pathogen invasion mechanisms and the cellular intricacies behind these fatal infections still remain unclear. The NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program project (2013-2018) aimed to develop an improved comprehensive understanding of the host response to a suite of viruses causing lethal infections leveraging a systems biology approach. Herein, PNNL sub-projects provide a never before released comprehensive infectious disease collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen primary experimental studies for enhanced open-access to viral Omics datasets and project lifecycle metadata. Secondary host-pathogen viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics (P), metabolomics (M), lipidomics (L), and transcriptomics (T) dataset downloads each have a direct relationship to a primary sample submission corresponding to a specific Influenza A virus [NCBITAXON:11320] experimental infection study. Host sample types include human lung adenocarcinoma cells ["Calu-3", BTO:0002750] and whole mouse lung [BTO:0000763] tissue collections.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE Office of Science (SC); National Institute of Allergy and Infectious Diseases (NIAID)
• Contributing Organization: Modeling Host Responses to Understand Severe Human Virus Infections Program Project
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1773428
• Report Number(s): LHVFLU; ICL102; ICL103; ICL104; ICL105; ICL106; IM101; IM102; IM103
• Availability: [e-mail]
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Virology [edam.topic:0781]
Immune Response [GO:0006955]
Human virus [NCIT:C14317]
Influenza A virus [NCBITAXON:11320]
Time Sampled Measurement Datasets [IAO:0000584]
Mass spectrometry data [edam.data:2536]
MassIVE dataset identifier [MS:1002487]
Gene expression profile data [edam.data:0928]
BioProject Accession Number [NCIT:C175890]
Omics [edam.topic:3391]
Multi-omics [edam.topic:4021]
data transformation [SIO:000594]
differential expression analysis [SWO:7000018]
Dataset Collection [schema:DataCatalog]