Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds

Lindsey, Jonathan S.; Zhang, Shaofei

Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds

Patent · Tue Nov 17 04:00:00 EST 2020

OSTI ID:1771632

Lindsey, Jonathan S.; Zhang, Shaofei

Described herein are bacteriochlorins comprising an annulated isocyclic ring such as a compound Formula I: or a metal conjugate thereof, wherein: R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, and Z are each as defined herein. Also described are methods and intermediates for the synthesis of bacteriochlorins comprising an annulated isocyclic ring, and methods of using such bacteriochlorins for, among other things, diagnostic and therapeutic purposes such as, e.g., luminescent compounds in flow cytometry, and/or as active agents in photodynamic therapy (PDT).

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Research Organization:: North Carolina State Univ., Raleigh, NC (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-05ER15661

Assignee:: North Carolina State University (Raleigh, NC)

Patent Number(s):: 10,836,774

Application Number:: 16/464,728

OSTI ID:: 1771632

Country of Publication:: United States

Language:: English

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