Unveiling molecular signatures of preeclampsia and gestational diabetes mellitus with multi-omics and innovative cheminformatics visualization tools

Odenkirk, Melanie T.; Stratton, Kelly G.; Gritsenko, Marina A.; Bramer, Lisa M.; Webb-Robertson, Bobbie-Jo M.; Bloodsworth, Kent J.; Weitz, Karl K.; Lipton, Anna K.; Monroe, Matthew E.; Ash, Jeremy; Fourches, Denis; Taylor, Brandie D.; Burnum-Johnson, Kristin E.; Baker, Erin S.

doi:10.1039/d0mo00074d

Title: Unveiling molecular signatures of preeclampsia and gestational diabetes mellitus with multi-omics and innovative cheminformatics visualization tools

Journal Article · Tue Dec 01 00:00:00 EST 2020 · Molecular Omics

DOI:https://doi.org/10.1039/d0mo00074d· OSTI ID:1770564

Odenkirk, Melanie T. ^[1];

^[2];

^[2]; Webb-Robertson, Bobbie-Jo M. ^[2];

^[2]; Weitz, Karl K. ^[2]; Lipton, Anna K. ^[2];

^[2]; Ash, Jeremy ^[1]; Fourches, Denis ^[1]; Taylor, Brandie D. ^[3];

^[2]; Baker, Erin S. ^[1]

North Carolina State University
BATTELLE (PACIFIC NW LAB)
Temple University

To fully enable the development of diagnostic tools and progressive pharmaceutical drugs, it is imperative to understand the molecular changes occurring before and during disease onset and progression. Systems biology assessments utilizing multi-omic analyses (e.g. the combination of proteomics, lipidomics, genomics, etc.) have shown enormous value in determining molecules prevalent in diseases and their associated mechanisms. Herein, we utilized multi-omic evaluations, multi-dimensional analysis methods, and new cheminformatics-based visualization tools to provide an in depth understanding of the molecular changes taking place in preeclampsia (PRE) and gestational diabetes mellitus (GDM) patients. Since PRE and GDM are two prevalent pregnancy complications that result in adverse health effects for both the mother and fetus during pregnancy and later in life, a better understanding of each is essential. The multi-omic evaluations performed here provide new insight into the end-stage molecular profiles of each disease, thereby supplying crucial information for earlier diagnosis and potential treatments.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1770564

Report Number(s):: PNNL-SA-152804

Journal Information:: Molecular Omics, Vol. 16, Issue 6

Country of Publication:: United States

Language:: English

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