|
Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors
|
journal
|
November 2016 |
|
The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors
|
journal
|
February 2015 |
|
Inhibition of Pim1 Kinase Activation Attenuates Allergen-Induced Airway Hyperresponsiveness and Inflammation
|
journal
|
April 2012 |
|
Structure-based design of low-nanomolar PIM kinase inhibitors
|
journal
|
February 2015 |
|
Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design
|
journal
|
June 2013 |
|
For better or for worse: the role of Pim oncogenes in tumorigenesis
|
journal
|
December 2010 |
|
Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser 112 gatekeeper site
|
journal
|
July 2004 |
|
Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor
|
journal
|
October 2009 |
|
Discovery of 3 H -Benzo[4,5]thieno[3,2- d ]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases
|
journal
|
November 2009 |
|
Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors
|
journal
|
October 2013 |
|
Identification of N -(4-((1 R ,3 S ,5 S )-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies
|
journal
|
October 2015 |
|
Inhibition of Pim1 kinase prevents peanut allergy by enhancing Runx3 expression and suppressing TH2 and TH17 T-cell differentiation
|
journal
|
October 2012 |
|
Hit to Lead Account of the Discovery of a New Class of Inhibitors of Pim Kinases and Crystallographic Studies Revealing an Unusual Kinase Binding Mode †
|
journal
|
April 2009 |
|
Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors
|
journal
|
June 2016 |
|
Structural Basis of Constitutive Activity and a Unique Nucleotide Binding Mode of Human Pim-1 Kinase
|
journal
|
February 2005 |
|
Overexpression of Pim-1 during progression of prostatic adenocarcinoma
|
journal
|
March 2006 |
|
Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors
|
journal
|
February 2012 |
|
Potential Use of Selective and Nonselective Pim Kinase Inhibitors for Cancer Therapy: Miniperspective
|
journal
|
September 2012 |
|
Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor
|
journal
|
December 2011 |
|
7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: A novel class of Pim kinase inhibitors with potent cell antiproliferative activity
|
journal
|
November 2011 |
|
A Selective PIM Kinase Inhibitor Is Highly Active In Multiple Myeloma: The Biology of Single Agent and PI3K/AKT/mTOR Combination Activity
|
journal
|
November 2010 |
|
Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases
|
journal
|
November 2011 |
|
Identification and structure–activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase
|
journal
|
May 2010 |
|
The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias.
|
journal
|
November 1989 |
|
Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents
|
journal
|
November 2012 |
|
A Selective PIM Kinase Inhibitor Is Highly Active In Multiple Myeloma: Mechanism of Action and Signal Transduction Studies
|
journal
|
November 2010 |
|
Inhibition of Pim-1 Kinase Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mice
|
journal
|
April 2012 |
|
Discovery of N -substituted 7-azaindoles as PIM1 kinase inhibitors – Part I
|
journal
|
October 2017 |
|
Structure and Substrate Specificity of the Pim-1 Kinase
|
journal
|
October 2005 |
|
Elucidation of fluorine's impact on p K a and in vitro Pgp-mediated efflux for a series of PDE9 inhibitors
|
journal
|
January 2018 |
|
The role of PIM kinases in human and mouse CD4+ T cell activation and inflammatory bowel disease
|
journal
|
January 2012 |
|
Rational Evolution of a Novel Type of Potent and Selective Proviral Integration Site in Moloney Murine Leukemia Virus Kinase 1 (PIM1) Inhibitor from a Screening-Hit Compound
|
journal
|
May 2012 |
|
Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases
|
journal
|
December 2013 |
|
Docking Study Yields Four Novel Inhibitors of the Protooncogene Pim-1 Kinase †
|
journal
|
March 2008 |
|
Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer
|
journal
|
September 2004 |
|
Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT 1D Receptor Ligands with Improved Pharmacokinetic Profiles
|
journal
|
June 1999 |
|
Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma
|
journal
|
April 2005 |
|
Mice Deficient for All PIM Kinases Display Reduced Body Size and Impaired Responses to Hematopoietic Growth Factors
|
journal
|
July 2004 |
|
Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors
|
journal
|
July 2013 |
|
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers
|
journal
|
February 2010 |
|
Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles
|
journal
|
September 2010 |
|
Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling
|
journal
|
October 2008 |
|
Discovery of N -substituted 7-azaindoles as Pan-PIM kinase inhibitors – Lead series identification – Part II
|
journal
|
October 2017 |
|
Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase
|
journal
|
June 2009 |
|
Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold
|
journal
|
May 2016 |
|
The PIM-2 Kinase Phosphorylates BAD on Serine 112 and Reverses BAD-induced Cell Death
|
journal
|
November 2003 |
|
Pim-1 Ligand-bound Structures Reveal the Mechanism of Serine/Threonine Kinase Inhibition by LY294002
|
journal
|
April 2005 |
|
Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors – Lead optimization – Part III
|
journal
|
February 2019 |
|
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
|
journal
|
January 2007 |