Upscaling X-ray nanoimaging to macroscopic specimens

Du, Ming; Di, Zichao; Gürsoy, Dogˇa; Xian, R. Patrick; Kozorovitskiy, Yevgenia; Jacobsen, Chris

doi:10.1107/S1600576721000194

Title: Upscaling X-ray nanoimaging to macroscopic specimens

Journal Article · Fri Feb 19 00:00:00 EST 2021 · Journal of Applied Crystallography (Online)

DOI:https://doi.org/10.1107/S1600576721000194· OSTI ID:1766352

Du, Ming; Di, Zichao; Gürsoy, Dogˇa; Xian, R. Patrick; Kozorovitskiy, Yevgenia;

Upscaling X-ray nanoimaging to macroscopic specimens has the potential for providing insights across multiple length scales, but its feasibility has long been an open question. By combining the imaging requirements and existing proof-of-principle examples in large-specimen preparation, data acquisition and reconstruction algorithms, the authors provide imaging time estimates for howX-ray nanoimaging can be scaled to macroscopic specimens. To arrive at this estimate, a phase contrast imaging model that includes plural scattering effects is used to calculate the required exposure and corresponding radiation dose. The coherent X-ray flux anticipated from upcoming diffraction-limited light sources is then considered. This imaging time estimation is in particular applied to the case of the connectomes of whole mouse brains. To image the connectome of the whole mouse brain, electron microscopy connectomics might require years, whereas optimized X-ray microscopy connectomics could reduce this to one week. Furthermore, this analysis points to challenges that need to be overcome (such as increased X-ray detector frame rate) and opportunities that advances in artificial-intelligence-based `smart' scanning might provide. While the technical advances required are daunting, it is shown that X-ray microscopy is indeed potentially applicable to nanoimaging of millimetre- or even centimetre-size specimens.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division; National Institutes of Health (NIH)

Grant/Contract Number:: AC02-06CH11357; R01MH115265; R01NS107539

OSTI ID:: 1766352

Alternate ID(s):: OSTI ID: 1774018

Journal Information:: Journal of Applied Crystallography (Online), Journal Name: Journal of Applied Crystallography (Online) Vol. 54 Journal Issue: 2; ISSN 1600-5767

Publisher:: International Union of Crystallography (IUCr)Copyright Statement

Country of Publication:: Denmark

Language:: English

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