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Title: Bisubstrate inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: Transition state anal

Journal Article · · Bioorgan. Med. Chem.
; ; ; ;

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; NCI; National Institutes of Health (NIH)
OSTI ID:
1765221
Journal Information:
Bioorgan. Med. Chem., Vol. 29
Country of Publication:
United States
Language:
ENGLISH

References (31)

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Specific inhibitors in vitamin biosynthesis. Part 7. Syntheses of blocked 7,8-dihydropteridines viaα-amino ketones journal January 1985
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2.0 Å X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue journal July 1999
Role of Protein Conformational Dynamics in the Catalysis by 6-Hydroxymethyl-7, 8-Dihydropterin Pyrophosphokinase journal April 2011
Reaction Trajectory of Pyrophosphoryl Transfer Catalyzed by 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase journal March 2004
Bisubstrate Analogue Inhibitors of 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase:  Synthesis and Biochemical and Crystallographic Studies † journal April 2001
Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties journal January 2012
Bisubstrate analog inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New lead exhibits a distinct binding mode journal July 2012
Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis journal July 2014
Dissecting the nucleotide binding properties of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase with fluorescent 3′(2)′-o-anthraniloyladenosine 5′-triphosphate journal May 2000
Chemical Transformation Is Not Rate-Limiting in the Reaction Catalyzed by Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase † journal July 2002
Exploring the Chemical Space around 8-Mercaptoguanine as a Route to New Inhibitors of the Folate Biosynthesis Enzyme HPPK journal April 2013
Structure-Based Design and Development of Functionalized Mercaptoguanine Derivatives as Inhibitors of the Folate Biosynthesis Pathway Enzyme 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus journal October 2014
Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli journal April 2016
The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase journal April 2014
In-silico analysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK): a potential drug target against Salmonella enterica serovar typhi journal June 2013
Fragment Screening on Staphylococcus aureus HPPK – a Folate Pathway Target journal January 2013
Catalytic Center Assembly of HPPK as Revealed by the Crystal Structure of a Ternary Complex at 1.25 Å Resolution journal October 2000
Dynamic Roles of Arginine Residues 82 and 92 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase:  Crystallographic Studies † , ‡ journal February 2003
Catalytic Roles of Arginine Residues 82 and 92 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase:  Site-Directed Mutagenesis and Biochemical Studies † journal February 2003
Essential Roles of a Dynamic Loop in the Catalysis of 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase † journal February 2004
Is the Critical Role of Loop 3 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase in Catalysis Due to Loop-3 Residues Arginine-84 and Tryptophan-89? Site-Directed Mutagenesis, Biochemical, and Crystallographic Studies † , ‡ journal June 2005
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Conjugation of Cell-Penetrating Peptides to Antimicrobial Peptides Enhances Antibacterial Activity journal September 2019
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