Genome-scale phylogeny and contrasting modes of genome evolution in the fungal phylum Ascomycota

Shen, Xing-Xing; Steenwyk, Jacob L.; LaBella, Abigail L.; Opulente, Dana A.; Zhou, Xiaofan; Kominek, Jacek; Li, Yuanning; Groenewald, Marizeth; Hittinger, Chris T.; Rokas, Antonis

doi:10.1126/sciadv.abd0079

Genome-scale phylogeny and contrasting modes of genome evolution in the fungal phylum Ascomycota

Journal Article · Wed Nov 04 00:00:00 EST 2020 · Science Advances

DOI:https://doi.org/10.1126/sciadv.abd0079· OSTI ID:1764995

^[1]; ^[2]; ^[2]; ^[3]; Zhou, Xiaofan ^[4]; ^[3]; ^[2]; ^[5]; ^[3]; ^[2]

Zhejiang Univ., Hangzhou (China); Vanderbilt University Department of Biological Sciences
Vanderbilt Univ., Nashville, TN (United States)
Univ. of Wisconsin, Madison, WI (United States)
South China Agricultural Univ., Guangzhou (China)
Westerdijk Fungal Biodiversity Inst. (Netherlands)

Ascomycota, the largest and most well-studied phylum of fungi, contains three subphyla: Saccharomycotina (budding yeasts), Pezizomycotina (filamentous fungi), and Taphrinomycotina (fission yeasts). Despite its importance, we lack a comprehensive genome-scale phylogeny or understanding of the similarities and differences in the mode of genome evolution within this phylum. By examining 1107 genomes from Saccharomycotina (332), Pezizomycotina (761), and Taphrinomycotina (14) species, we inferred a robust genome-wide phylogeny that resolves several contentious relationships and estimated that the Ascomycota last common ancestor likely originated in the Ediacaran period. Comparisons of genomic properties revealed that Saccharomycotina and Pezizomycotina differ greatly in their genome properties and enabled inference of the direction of evolutionary change. The Saccharomycotina typically have smaller genomes, lower guanine-cytosine contents, lower numbers of genes, and higher rates of molecular sequence evolution compared with Pezizomycotina. These results provide a robust evolutionary framework for understanding the diversity and ecological lifestyles of the largest fungal phylum.

View Accepted Manuscript (DOE)

Research Organization:: Great Lakes Bioenergy Research Center, Madison, WI (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0018409

OSTI ID:: 1764995

Alternate ID(s):: OSTI ID: 1764996

Journal Information:: Science Advances, Journal Name: Science Advances Journal Issue: 45 Vol. 6; ISSN 2375-2548

Publisher:: AAASCopyright Statement

Country of Publication:: United States

Language:: English

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