Evaluation of Waveform Profiles for Traveling Wave Ion Mobility Separations in Structures for Lossless Ion Manipulations

Conant, Christopher R.; Attah, Isaac K.; Garimella, Sandilya B. B.; Nagy, Gabe; Bilbao, Aivett; Smith, Richard D.; Ibrahim, Yehia M.

doi:10.1021/jasms.0c00282

Evaluation of Waveform Profiles for Traveling Wave Ion Mobility Separations in Structures for Lossless Ion Manipulations

Journal Article · Fri Oct 30 00:00:00 EDT 2020 · Journal of the American Society for Mass Spectrometry

DOI:https://doi.org/10.1021/jasms.0c00282· OSTI ID:1763296

Conant, Christopher R. ^[1]; Attah, Isaac K. ^[1]; ^[1]; ^[1]; ^[1]; ^[1]; ^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Structures for lossless ion manipulations (SLIM) have recently enabled a powerful implementation of traveling wave ion mobility spectrometry (TWIMS) for ultra-high resolution separations. However, optimization of experimental parameters remains challenging. Most TWIMS separations have utilized square-shaped waveforms applied by time-dependent voltage stepping across a repeating sets of electrodes; however, alternative waveforms may provide further improvements to resolution. In this work, we characterize five waveforms (including square and sine) in terms of their transmission efficiency, IMS resolution, and resolving power, and explore the effects of TW amplitude and speed on the performance of each. We found, consistent with previous work, separations were generally improved with higher TW amplitudes, moderately improved by lower speeds (limited by ion ‘surfing’ with the waves), and found decreases in signal intensity at the extremes of operating conditions. The triangle and asymmetric ‘ramp forward’ shaped profiles were found to provide modestly greater resolution and resolving power, an observation we tentatively attribute to their relatively uniform fields and minimal low-field regions.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)

Sponsoring Organization:: National Cancer Institute (NCI); National Institute of General Medical Sciences (NIGMS); National Institutes of Health (NIH); USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1763296

Report Number(s):: PNNL-SA--154551

Journal Information:: Journal of the American Society for Mass Spectrometry, Journal Name: Journal of the American Society for Mass Spectrometry Journal Issue: 1 Vol. 32; ISSN 1044-0305

Publisher:: American Society for Mass SpectrometryCopyright Statement

Country of Publication:: United States

Language:: English

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