Tissue-Specific Regulation of the Wnt/[beta]-Catenin Pathway by PAGE4 Inhibition of Tankyrase

Koirala, Sajjan; Klein, Jonathon; Zheng, Yumei; Glenn, Nicole O.; Eisemann, Travis; Tacer, Klementina Fon; Miller, Darcie J.; Kulak, Ozlem; Lu, Meifen; Finkelstein, David B.; Neale, Geoffrey; Tillman, Heather; Vogel, Peter; Strand, Douglas W.; Lum, Lawrence; Brautigam, Chad A.; Pascal, John M.; Clements, Wilson K.; Potts, Patrick Ryan

doi:10.1016/j.celrep.2020.107922

Tissue-Specific Regulation of the Wnt/[beta]-Catenin Pathway by PAGE4 Inhibition of Tankyrase

Journal Article · Wed Jul 01 04:00:00 EDT 2020 · Cell Reports

DOI:https://doi.org/10.1016/j.celrep.2020.107922· OSTI ID:1763099

Koirala, Sajjan; Klein, Jonathon; Zheng, Yumei; Glenn, Nicole O.; Eisemann, Travis; Tacer, Klementina Fon; Miller, Darcie J.; Kulak, Ozlem; Lu, Meifen; Finkelstein, David B.; Neale, Geoffrey; Tillman, Heather; Vogel, Peter; Strand, Douglas W.; Lum, Lawrence; Brautigam, Chad A.; Pascal, John M.; Clements, Wilson K.; Potts, Patrick Ryan

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; FOREIGN

OSTI ID:: 1763099

Journal Information:: Cell Reports, Journal Name: Cell Reports Journal Issue: (3) Vol. 32

Country of Publication:: United States

Language:: ENGLISH

References (75)

PDGFRα ⁺ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo Greicius, Gediminas; Kabiri, Zahra; Sigmundsson, Kristmundur Proceedings of the National Academy of Sciences, Vol. 115, Issue 14 https://doi.org/10.1073/pnas.1713510115	journal	March 2018
Calculations and Publication-Quality Illustrations for Analytical Ultracentrifugation Data Brautigam, Chad A. Methods in Enzymology https://doi.org/10.1016/bs.mie.2015.05.001	book	January 2015
Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling Callow, Marinella G.; Tran, Hoanh; Phu, Lilian PLoS ONE, Vol. 6, Issue 7 https://doi.org/10.1371/journal.pone.0022595	journal	July 2011
Refinement of Macromolecular Structures by the Maximum-Likelihood Method Murshudov, G. N.; Vagin, A. A.; Dodson, E. J. Acta Crystallographica Section D Biological Crystallography, Vol. 53, Issue 3 https://doi.org/10.1107/S0907444996012255	journal	May 1997
Wnt signalling in stem cells and cancer Reya, Tannishtha; Clevers, Hans Nature, Vol. 434, Issue 7035 https://doi.org/10.1038/nature03319	journal	April 2005
Can we safely target the WNT pathway? Kahn, Michael Nature Reviews Drug Discovery, Vol. 13, Issue 7 https://doi.org/10.1038/nrd4233	journal	July 2014
The wnt Signaling Pathway in Development and Disease Logan, Catriona Y.; Nusse, Roel Annual Review of Cell and Developmental Biology, Vol. 20, Issue 1 https://doi.org/10.1146/annurev.cellbio.20.010403.113126	journal	November 2004
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin Huelsken, Joerg; Vogel, Regina; Erdmann, Bettina Cell, Vol. 105, Issue 4 https://doi.org/10.1016/S0092-8674(01)00336-1	journal	May 2001
Control of β-Catenin Stability Salic, Adrian; Lee, Ethan; Mayer, Leslie Molecular Cell, Vol. 5, Issue 3 https://doi.org/10.1016/S1097-2765(00)80446-3	journal	March 2000
Apc Tumor Suppressor Gene Is the “Zonation-Keeper” of Mouse Liver Benhamouche, Samira; Decaens, Thomas; Godard, Cécile Developmental Cell, Vol. 10, Issue 6 https://doi.org/10.1016/j.devcel.2006.03.015	journal	June 2006
Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins Wang, Wenqi; Li, Nan; Li, Xu Cell Reports, Vol. 13, Issue 3 https://doi.org/10.1016/j.celrep.2015.09.014	journal	October 2015
Detection and analysis of ?-catenin mutations in prostate cancer Chesire, Dennis R.; Ewing, Charles M.; Sauvageot, Jurga The Prostate, Vol. 45, Issue 4 https://doi.org/10.1002/1097-0045(20001201)45:4<323::AID-PROS7>3.0.CO;2-W	journal	January 2000
Studying multiprotein complexes by multisignal sedimentation velocity analytical ultracentrifugation Balbo, A.; Minor, K. H.; Velikovsky, C. A. Proceedings of the National Academy of Sciences, Vol. 102, Issue 1 https://doi.org/10.1073/pnas.0408399102	journal	December 2004
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
PAGE4 Positivity Is Associated with Attenuated AR Signaling and Predicts Patient Survival in Hormone-Naive Prostate Cancer Sampson, Natalie; Ruiz, Christian; Zenzmaier, Christoph The American Journal of Pathology, Vol. 181, Issue 4 https://doi.org/10.1016/j.ajpath.2012.06.040	journal	October 2012
Liver-specific loss of β-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice Sekine, Shigeki; Lan, Billy Yu-Ang; Bedolli, Melanie Hepatology, Vol. 43, Issue 4 https://doi.org/10.1002/hep.21131	journal	January 2006
Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase Yeh, Tsung-Yin J.; Sbodio, Juan I.; Tsun, Zhi-Yang Biochemical Journal, Vol. 402, Issue 2 https://doi.org/10.1042/BJ20060793	journal	February 2007
Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification Eisemann, Travis; McCauley, Michael; Langelier, Marie-France Structure, Vol. 24, Issue 10 https://doi.org/10.1016/j.str.2016.07.014	journal	October 2016
WNT and DKK Determine Hair Follicle Spacing Through a Reaction-Diffusion Mechanism Sick, S.; Reinker, S.; Timmer, J. Science, Vol. 314, Issue 5804 https://doi.org/10.1126/science.1130088	journal	December 2006
Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes Thorvaldsen, Tor Espen; Pedersen, Nina Marie; Wenzel, Eva M. Molecular Cancer Research, Vol. 13, Issue 11 https://doi.org/10.1158/1541-7786.MCR-15-0125	journal	June 2015
Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling Sennett, Rachel; Rendl, Michael Seminars in Cell & Developmental Biology, Vol. 23, Issue 8 https://doi.org/10.1016/j.semcdb.2012.08.011	journal	October 2012
MolProbity : all-atom structure validation for macromolecular crystallography Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042073	journal	December 2009
Targeting the Wnt pathway in zebrafish as a screening method to identify novel therapeutic compounds Robertson, Joshua K.; Danzmann, Kestral; Charles, Sherise Experimental Biology and Medicine, Vol. 239, Issue 2 https://doi.org/10.1177/1535370213514322	journal	December 2013
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
Wnt/β-Catenin Signaling in Development and Disease Clevers, Hans Cell, Vol. 127, Issue 3 https://doi.org/10.1016/j.cell.2006.10.018	journal	November 2006
Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease Guettler, Sebastian; LaRose, Jose; Petsalaki, Evangelia Cell, Vol. 147, Issue 6 https://doi.org/10.1016/j.cell.2011.10.046	journal	December 2011
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities Nusse, Roel; Clevers, Hans Cell, Vol. 169, Issue 6 https://doi.org/10.1016/j.cell.2017.05.016	journal	June 2017
Resolution of Sister Telomere Association Is Required for Progression Through Mitosis Dynek, J. N. Science, Vol. 304, Issue 5667 https://doi.org/10.1126/science.1094754	journal	April 2004
Binding of GSK3beta to the APC-beta -Catenin Complex and Regulation of Complex Assembly Rubinfeld, B.; Albert, I.; Porfiri, E. Science, Vol. 272, Issue 5264 https://doi.org/10.1126/science.272.5264.1023	journal	May 1996
Linking Colorectal Cancer to Wnt Signaling Bienz, Mariann; Clevers, Hans Cell, Vol. 103, Issue 2 https://doi.org/10.1016/S0092-8674(00)00122-7	journal	October 2000
Activation of β-Catenin Signaling in Androgen Receptor–Negative Prostate Cancer Cells Wan, Xinhai; Liu, Jie; Lu, Jing-Fang Clinical Cancer Research, Vol. 18, Issue 3 https://doi.org/10.1158/1078-0432.CCR-11-2521	journal	January 2012
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling Zhang, Yue; Liu, Shanming; Mickanin, Craig Nature Cell Biology, Vol. 13, Issue 5 https://doi.org/10.1038/ncb2222	journal	April 2011
DKK1, a negative regulator of Wnt signaling, is a target of the β-catenin/TCF pathway Niida, Atsushi; Hiroko, Takatoshi; Kasai, Mana Oncogene, Vol. 23, Issue 52 https://doi.org/10.1038/sj.onc.1207892	journal	September 2004
Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity Kulkarni, Prakash; Jolly, Mohit Kumar; Jia, Dongya Proceedings of the National Academy of Sciences, Vol. 114, Issue 13 https://doi.org/10.1073/pnas.1700082114	journal	March 2017
Endothelial Wnts regulate β‐catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt–Wnt situation Preziosi, Morgan; Okabe, Hirohisa; Poddar, Minakshi Hepatology Communications, Vol. 2, Issue 7 https://doi.org/10.1002/hep4.1196	journal	May 2018
HTSeq--a Python framework to work with high-throughput sequencing data Anders, S.; Pyl, P. T.; Huber, W. Bioinformatics, Vol. 31, Issue 2 https://doi.org/10.1093/bioinformatics/btu638	journal	September 2014
Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling Schuck, Peter Biophysical Journal, Vol. 78, Issue 3 https://doi.org/10.1016/S0006-3495(00)76713-0	journal	March 2000
An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members Gjerstorff, M. F.; Ditzel, H. J. Tissue Antigens, Vol. 71, Issue 3 https://doi.org/10.1111/j.1399-0039.2007.00997.x	journal	March 2008
Lymphoid enhancer factor/T cell factor expression in colorectal cancer Waterman, Marian L. Cancer and Metastasis Reviews, Vol. 23, Issue 1/2 https://doi.org/10.1023/A:1025858928620	journal	January 2004
Cancer/testis antigens, gametogenesis and cancer Simpson, Andrew J. G.; Caballero, Otavia L.; Jungbluth, Achim Nature Reviews Cancer, Vol. 5, Issue 8 https://doi.org/10.1038/nrc1669	journal	July 2005
limma powers differential expression analyses for RNA-sequencing and microarray studies Ritchie, Matthew E.; Phipson, Belinda; Wu, Di Nucleic Acids Research, Vol. 43, Issue 7 https://doi.org/10.1093/nar/gkv007	journal	January 2015
Cancer/Testis Antigens: “Smart” Biomarkers for Diagnosis and Prognosis of Prostate and Other Cancers Kulkarni, Prakash; Uversky, Vladimir International Journal of Molecular Sciences, Vol. 18, Issue 4 https://doi.org/10.3390/ijms18040740	journal	March 2017
Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase Xu, Wenshu; Lau, Yu Heng; Fischer, Gerhard Journal of the American Chemical Society, Vol. 139, Issue 6 https://doi.org/10.1021/jacs.6b10234	journal	February 2017
Transcriptomes of human prostate cells Oudes, Asa J.; Campbell, Dave S.; Sorensen, Carrie M. BMC Genomics, Vol. 7, Issue 1 https://doi.org/10.1186/1471-2164-7-92	journal	April 2006
Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase Pollock, Katie; Liu, Manjuan; Zaleska, Mariola Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-55240-5	journal	December 2019
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin Kitagawa, Masatoshi; Hatakeyama, Shigetsugu; Shirane, Michiko The EMBO Journal, Vol. 18, Issue 9 https://doi.org/10.1093/emboj/18.9.2401	journal	May 1999
The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell Hart, M.; Concordet, J-P.; Lassot, I. Current Biology, Vol. 9, Issue 4 https://doi.org/10.1016/S0960-9822(99)80091-8	journal	February 1999
The -Catenin Destruction Complex Stamos, J. L.; Weis, W. I. Cold Spring Harbor Perspectives in Biology, Vol. 5, Issue 1 https://doi.org/10.1101/cshperspect.a007898	journal	November 2012
A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases Lee, Anna K.; Potts, Patrick Ryan Journal of Molecular Biology, Vol. 429, Issue 8 https://doi.org/10.1016/j.jmb.2017.03.005	journal	April 2017
MAGE cancer-testis antigens protect the mammalian germline under environmental stress Fon Tacer, Klementina; Montoya, Marhiah C.; Oatley, Melissa J. Science Advances, Vol. 5, Issue 5 https://doi.org/10.1126/sciadv.aav4832	journal	May 2019
How good are my data and what is the resolution? Evans, Philip R.; Murshudov, Garib N. Acta Crystallographica Section D Biological Crystallography, Vol. 69, Issue 7 https://doi.org/10.1107/S0907444913000061	journal	June 2013
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos Molenaar, Miranda; van de Wetering, Marc; Oosterwegel, Mariette Cell, Vol. 86, Issue 3 https://doi.org/10.1016/S0092-8674(00)80112-9	journal	August 1996
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling Huang, Shih-Min A.; Mishina, Yuji M.; Liu, Shanming Nature, Vol. 461, Issue 7264 https://doi.org/10.1038/nature08356	journal	September 2009
Cancer/Testis Antigen PAGE4, a Regulator of c-Jun Transactivation, Is Phosphorylated by Homeodomain-Interacting Protein Kinase 1, a Component of the Stress-Response Pathway Mooney, Steven M.; Qiu, Ruoyi; Kim, John J. Biochemistry, Vol. 53, Issue 10 https://doi.org/10.1021/bi500013w	journal	March 2014
Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms Wei, Xing; Zhang, Li; Zhou, Zhicheng Cell Stem Cell, Vol. 24, Issue 5 https://doi.org/10.1016/j.stem.2019.03.010	journal	May 2019
OMIP-040: Optimized gating of human prostate cellular subpopulations: OMIP-040 Henry, Gervaise H.; Loof, Nicolas; Strand, Douglas W. Cytometry Part A, Vol. 91, Issue 12 https://doi.org/10.1002/cyto.a.23187	journal	August 2017
Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment Morrone, S.; Cheng, Z.; Moon, R. T. Proceedings of the National Academy of Sciences, Vol. 109, Issue 5 https://doi.org/10.1073/pnas.1116618109	journal	January 2012
Wnt/β-catenin signalling in prostate cancer Kypta, Robert M.; Waxman, Jonathan Nature Reviews Urology, Vol. 9, Issue 8 https://doi.org/10.1038/nrurol.2012.116	journal	June 2012
Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination Wang, Z.; Michaud, G. A.; Cheng, Z. Genes & Development, Vol. 26, Issue 3 https://doi.org/10.1101/gad.182618.111	journal	January 2012
Functional Subdomain in the Ankyrin Domain of Tankyrase 1 Required for Poly(ADP-Ribosyl)ation of TRF1 and Telomere Elongation Seimiya, Hiroyuki; Muramatsu, Yukiko; Smith, Susan Molecular and Cellular Biology, Vol. 24, Issue 5 https://doi.org/10.1128/MCB.24.5.1944-1955.2004	journal	March 2004
PP2A:B56 is required for Wnt/ -catenin signaling during embryonic development Yang, J. Development, Vol. 130, Issue 23 https://doi.org/10.1242/dev.00762	journal	December 2003
The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro Winston, J. T.; Strack, P.; Beer-Romero, P. Genes & Development, Vol. 13, Issue 3 https://doi.org/10.1101/gad.13.3.270	journal	February 1999
Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal DaRosa, Paul A.; Wang, Zhizhi; Jiang, Xiaomo Nature, Vol. 517, Issue 7533 https://doi.org/10.1038/nature13826	journal	October 2014
Wnt/β-Catenin Signaling and Disease Clevers, Hans; Nusse, Roel Cell, Vol. 149, Issue 6 https://doi.org/10.1016/j.cell.2012.05.012	journal	June 2012
Functional interaction of β-catenin with the transcription factor LEF-1 Behrens, Jürgen; von Kries, Jens P.; Kühl, Michael Nature, Vol. 382, Issue 6592 https://doi.org/10.1038/382638a0	journal	August 1996
Tankyrase, a Poly(ADP-Ribose) Polymerase at Human Telomeres Smith, S. Science, Vol. 282, Issue 5393 https://doi.org/10.1126/science.282.5393.1484	journal	November 1998
Fully automated 5-plex fluorescent immunohistochemistry with tyramide signal amplification and same species antibodies Zhang, Wenjun; Hubbard, Antony; Jones, Tobin Laboratory Investigation, Vol. 97, Issue 7 https://doi.org/10.1038/labinvest.2017.37	journal	May 2017
Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase Eisemann, Travis; Langelier, Marie-France; Pascal, John M. Journal of Biological Chemistry, Vol. 294, Issue 40 https://doi.org/10.1074/jbc.RA119.009200	journal	August 2019
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin Gat, Uri; DasGupta, Ramanuj; Degenstein, Linda Cell, Vol. 95, Issue 5 https://doi.org/10.1016/S0092-8674(00)81631-1	journal	November 1998
The MAGE protein family and cancer Weon, Jenny L.; Potts, Patrick Ryan Current Opinion in Cell Biology, Vol. 37 https://doi.org/10.1016/j.ceb.2015.08.002	journal	December 2015
Tankyrase 1 and Tankyrase 2 Are Essential but Redundant for Mouse Embryonic Development Chiang, Y. Jeffrey; Hsiao, Susan J.; Yver, Dena PLoS ONE, Vol. 3, Issue 7 https://doi.org/10.1371/journal.pone.0002639	journal	July 2008
The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway Lee, Ethan; Salic, Adrian; Krüger, Roland PLoS Biology, Vol. 1, Issue 1 https://doi.org/10.1371/journal.pbio.0000010	journal	October 2003
Rapid evolution of cancer/testis genes on the X chromosome Stevenson, Brian J.; Iseli, Christian; Panji, Sumir BMC Genomics, Vol. 8, Issue 1 https://doi.org/10.1186/1471-2164-8-129	journal	January 2007
Tankyrase 2 Poly(ADP-Ribose) Polymerase Domain-Deleted Mice Exhibit Growth Defects but Have Normal Telomere Length and Capping Hsiao, Susan J.; Poitras, Marc F.; Cook, Brandoch D. Molecular and Cellular Biology, Vol. 26, Issue 6 https://doi.org/10.1128/MCB.26.6.2044-2054.2006	journal	March 2006

Similar Records

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase

Journal Article · Tue Jun 30 20:00:00 EDT 2020 · Cell Reports · OSTI ID:1640259

Disruption of Wnt/[beta]-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells

Journal Article · Fri Oct 30 00:00:00 EDT 2015 · Mol. Cell Biol. · OSTI ID:1208678

Murrayafoline A attenuates the Wnt/{beta}-catenin pathway by promoting the degradation of intracellular {beta}-catenin proteins

Journal Article · Thu Dec 31 23:00:00 EST 2009 · Biochemical and Biophysical Research Communications · OSTI ID:22199993

Tissue-Specific Regulation of the Wnt/[beta]-Catenin Pathway by PAGE4 Inhibition of Tankyrase

Citation Formats

References (75)

Similar Records

Related Subjects