Evaluation of a visual interpretation method for tau-PET with 18F-flortaucipir

Sonni, Ida; Lesman Segev, Orit H.; Baker, Suzanne L.; Iaccarino, Leonardo; Korman, Deniz; Rabinovici, Gil D.; Jagust, William J.; Landau, Susan M.; La Joie, Renaud

doi:10.1002/dad2.12133

Evaluation of a visual interpretation method for tau-PET with ¹⁸F-flortaucipir

Journal Article · Sat Nov 28 00:00:00 EST 2020 · Alzheimer's & Dementia. Diagnosis, Assessment & Disease Monitoring

DOI:https://doi.org/10.1002/dad2.12133· OSTI ID:1762162

^[1]; Lesman Segev, Orit H. ^[2]; Baker, Suzanne L. ^[3]; Iaccarino, Leonardo ^[4]; Korman, Deniz ^[5]; Rabinovici, Gil D. ^[6]; Jagust, William J. ^[7]; Landau, Susan M. ^[5]; ^[4]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Los Angeles, CA (United States)
Univ. of California, San Francisco, CA (United States); Sheba Medical Center, Ramat Gan (Israel)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Univ. of California, San Francisco, CA (United States)
Univ. of California, Berkeley, CA (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, San Francisco, CA (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States)

Introduction: Positron emission tomography targeting tau (tau-PET) is a promising diagnostic tool for the identification of Alzheimer's disease (AD). Currently available data rely on quantitative measures, and a visual interpretation method, critical for clinical translation, is needed. Methods: In this work, we developed a visual interpretation method for ¹⁸F-flortaucipir tau-PET and tested it on 274 individuals (cognitively normal controls, patients with mild cognitive impairment [MCI], AD dementia, and non-AD diagnoses). Two readers interpreted ¹⁸F-flortaucipir PET using two complementary indices: a global visual score and a visual distribution pattern. Results: Global visual scores were reliable, correlated with global cortical ¹⁸F-flortaucipir standardized uptake value ratio (SUVR) and were associated with clinical diagnosis and amyloid status. The AD-like ¹⁸F-flortaucipir pattern had good sensitivity and specificity to identify amyloid-positive patients with AD dementia or MCI. Discussion: This ¹⁸F-flortaucipir visual rating scheme is associated with SUVR quantification, clinical diagnosis, and amyloid status, and constitutes a promising approach to tau measurement in clinical settings.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: Alzheimer's Association; Alzheimer's Disease Neuroimaging Initiative; National Institute on Aging; USDOD; USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1762162

Journal Information:: Alzheimer's & Dementia. Diagnosis, Assessment & Disease Monitoring, Journal Name: Alzheimer's & Dementia. Diagnosis, Assessment & Disease Monitoring Journal Issue: 1 Vol. 12; ISSN 2352-8729

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
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qualitative assessment
tau positron emission tomography
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Evaluation of a visual interpretation method for tau-PET with 18F-flortaucipir

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References (49)

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Evaluation of a visual interpretation method for tau-PET with ¹⁸F-flortaucipir