Hitting the sweet spot: exploiting HIV-1 glycan shield for induction of broadly neutralizing antibodies

Wagh, Kshitij; Hahn, Beatrice H.; Korber, Bette

doi:10.1097/coh.0000000000000639

Hitting the sweet spot: exploiting HIV-1 glycan shield for induction of broadly neutralizing antibodies

Journal Article · Sat Jul 25 00:00:00 EDT 2020 · Current Opinion in HIV and AIDS

DOI:https://doi.org/10.1097/coh.0000000000000639· OSTI ID:1756809

Wagh, Kshitij ^[1]; Hahn, Beatrice H. ^[2]; Korber, Bette ^[3]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Univ. of Pennsylvania, Philadelphia, PA (United States)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States); New Mexico Consortium, Los Alamos, NM (United States)

The surface of the HIV-1 Env glycoprotein, the target of neutralizing antibodies, is extensively covered by N-linked glycans that create a glycan shield. Broadly neutralizing antibodies (bNAbs), the primary targets of HIV-1 vaccine design, have to negotiate this glycan shield. Here, we review the barriers and opportunities that the HIV-1 glycan shield presents for vaccine induction of bNAbs.

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Laboratory Directed Research and Development (LDRD) Program

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 1756809

Report Number(s):: LA-UR--20-26631

Journal Information:: Current Opinion in HIV and AIDS, Journal Name: Current Opinion in HIV and AIDS Journal Issue: 5 Vol. 15; ISSN 1746-630X

Publisher:: Wolters Kluwer Health, Inc.Copyright Statement

Country of Publication:: United States

Language:: English

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Hitting the sweet spot: exploiting HIV-1 glycan shield for induction of broadly neutralizing antibodies

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