Power frequency magnetic fields do not contribute to transformation of JB6 cells.

Journal Article · Tue Jul 15 04:00:00 EDT 1997 · Carcinogenesis

DOI:https://doi.org/10.1093/carcin/18.7.1365· OSTI ID:1756020

Saffer, Jeffrey D. ^[1]; Chen, Guang ^[1]; Colburn, Nancy H. ^[2]; Colburn, Nancy H. ^[2]; Thurston, Sarah J. ^[1]

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1. BATTELLE (PACIFIC NW LAB)
2. National Cancer Institute

The potential for power frequency magnetic fields to enhance neoplastic transformation has been investigated in vitro using promotion-sensitive mouse epidermal JB6 cells. In a soft agar assay, 60-Hz magnetic fields of 0.01, 0.1, 1.0, or 1.1 mT flux density did not induce anchorage-independent growth. In addition, these magnetic fields did not enhance tumor promoter-induced transformation showing no increase in the maximum number of transformed colonies and no shift in the dose-response curve. Thus, these data do not support the notion that environmental exposures to magnetic fields contribute to transformation.

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1756020
• Report Number(s): PNNL-SA-28896
• Journal Information: Carcinogenesis, Journal Name: Carcinogenesis Journal Issue: 7 Vol. 18; ISSN 1460-2180
• Country of Publication: United States
• Language: English

Related Subjects

epidermis
Agar
neoplastic cell transformation
dose-response relationship
drug
environmental exposure
Malta
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Mice
neoplasms
movement time