Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Integration among databases and data sets to support productive nanotechnology: Challenges and recommendations

Journal Article · · NanoImpact
 [1];  [2];  [3];  [2];  [2];  [4];  [4];  [5];  [6];  [7];  [8];  [9];  [10];  [11];  [12];  [13];  [14]
  1. Carnegie Mellon Univ., Pittsburgh, PA (United States); Duke Univ., Durham, NC (United States)
  2. Maastricht Univ. (The Netherlands)
  3. R&R Data Services, Gaithersburg, MD (United States); CODATA-VAMAS Working Group on Nanomaterials, Paris (France)
  4. Leidos Biomedical Research, Inc., Frederick, MD (United States)
  5. Oregon State Univ., Corvallis, OR (United States)
  6. National Inst. for Occupational Safety and Health, Morgantown, WV (United States)
  7. IdeaConsult, Ltd., Sofia (Bulgaria)
  8. Virginia Commonwealth Univ., Richmond, VA (United States)
  9. Univ. of Leeds (United Kingdom); Liverpool John Moores Univ. (United Kingdom)
  10. RTI International, Triangle Park, NC (United States)
  11. Nordic Quantum Computing Group, Oslo (Norway)
  12. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  13. National Technical Univ., Athens (Greence); ATHENA Research and Innovation Centre, Athens (Greece)
  14. Duke Univ., Durham, NC (United States)
This work is one of a series of articles by the Nanomaterial Data Curation Initiative. Other articles in this series discuss data curation workflows, data completeness and quality, curator responsibilities, and metadata. Many groups within the broad nanotechnology field are already developing data repositories and tools driven by their individual organizational goals. Integrating these data across disciplines, and with other non-nanotechnology resources, can support multiple objectives by reusing the same information, and can serve as the impetus for novel scientific discoveries through deeper data analyses. Based on the results of a community-based survey of organizations that maintain nanomaterial repositories, this article discusses current data integration practices in nanoinformatics and mature fields such as genomics, as well as nanotechnology-specific challenges impacting data integration. Recommendations for achieving integration of existing operational nanotechnology resources, as based on results from a community-wide survey, are presented herein. Nanotechnology-specific data integration challenges, if effectively resolved, can foster the application and validation of nanotechnology within and across disciplines.
Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
European Union; National Institutes of Health (NIH); USDOE
Grant/Contract Number:
AC05-76RL01830
OSTI ID:
1737352
Alternate ID(s):
OSTI ID: 1439666
Report Number(s):
PNNL-SA--118813
Journal Information:
NanoImpact, Journal Name: NanoImpact Vol. 9; ISSN 2452-0748
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (63)

A Systematic Approach for Evaluating the Quality of Experimental Toxicological and Ecotoxicological Data journal February 1997
Scientific Lenses to Support Multiple Views over Linked Chemistry Data book January 2014
Chemical databases: curation or integration by user-defined equivalence? journal July 2015
NanoParticle Ontology for cancer nanotechnology research journal February 2011
Emerging practices for mapping and linking life sciences data using RDF — A case series journal July 2012
Jaqpot Quattro: A Novel Computational Web Platform for Modeling and Analysis in Nanoinformatics journal August 2017
A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury journal July 2017
The Semantic Web journal May 2001
How should the completeness and quality of curated nanomaterial data be evaluated? journal January 2016
Impact of storage conditions and storage time on silver nanoparticles' physicochemical properties and implications for their biological effects journal January 2015
BioPortal: ontologies and integrated data resources at the click of a mouse journal May 2009
ChEBI in 2016: Improved services and an expanding collection of metabolites journal October 2015
PubChem Substance and Compound databases journal September 2015
AMBIT RESTful web services: an implementation of the OpenTox application programming interface journal May 2011
eNanoMapper: harnessing ontologies to enable data integration for nanomaterial risk assessment journal March 2015
Extracting more value from data silos: using the semantic web to link chemistry and biology for innovation journal October 2013
Bioconductor : open software development for computational biology and bioinformatics text January 2004
The European Commission's recommendation on the definition of nanomaterial makes an impact journal August 2012
Environmental impacts of nanomaterials: providing comprehensive information on exposure, transport and ecotoxicity - the project DaNa2.0 text January 2014
Informatics and standards for nanomedicine technology
  • Thomas, Dennis G.; Klaessig, Fred; Harper, Stacey L.
  • Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, Vol. 3, Issue 5 https://doi.org/10.1002/wnan.152
journal June 2011
Toward principles for the design of ontologies used for knowledge sharing? journal November 1995
Nanomaterial registry: database that captures the minimal information about nanomaterial physico-chemical characteristics journal January 2014
A Definition Framework for the Terms Nanomaterial and Nanoparticle journal January 2016
A Database Perspective on Consuming Linked Data on the Web journal August 2010
Open PHACTS: semantic interoperability for drug discovery journal November 2012
NCI Thesaurus: A semantic model integrating cancer-related clinical and molecular information journal February 2007
Dependence of QSAR Models on the Selection of Trial Descriptor Sets: A Demonstration Using Nanotoxicity Endpoints of Decorated Nanotubes journal December 2012
Minimum information about a microarray experiment (MIAME)—toward standards for microarray data journal December 2001
The FAIR Guiding Principles for scientific data management and stewardship journal March 2016
Impact of storage conditions and storage time on silver nanoparticles' physicochemical properties and implications for their biological effects journal January 2015
Data Sharing journal January 2016
Current situation on the availability of nanostructure–biological activity data journal January 2015
The Nanoparticle Information Library (NIL): A Prototype for Linking and Sharing Emerging Data journal October 2007
Considerations about the implementation of a public knowledge base regarding nanotechnology journal January 2014
The Chemical Translation Service--a web-based tool to improve standardization of metabolomic reports journal September 2010
The EBI RDF platform: linked open data for the life sciences journal January 2014
Entrez Gene: gene-centered information at NCBI journal December 2004
DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs journal November 2010
Identifiers.org and MIRIAM Registry: community resources to provide persistent identification journal December 2011
PubChem BioAssay: 2014 update journal November 2013
Application of an Informatics-Based Decision-Making Framework and Process to the Assessment of Radiation Safety in Nanotechnology journal January 2015
The description of nanomaterials: A multi-disiciplinary uniform description system conference November 2014
'Omics Data Sharing journal October 2009
Challenges and Opportunities of Open Data in Ecology journal February 2011
A journey to Semantic Web query federation in the life sciences journal October 2009
The BridgeDb framework: standardized access to gene, protein and metabolite identifier mapping services journal January 2010
ISA-TAB-Nano: A Specification for Sharing Nanomaterial Research Data in Spreadsheet-based Format journal January 2013
Linked open drug data for pharmaceutical research and development journal May 2011
Bioconductor: open software development for computational biology and bioinformatics journal September 2004
Environmental impacts of nanomaterials: providing comprehensive information on exposure, transport and ecotoxicity - the project DaNa2.0 journal October 2014
UniChem: extension of InChI-based compound mapping to salt, connectivity and stereochemistry layers journal September 2014
InChI, the IUPAC International Chemical Identifier journal May 2015
The Chemical Information Ontology: Provenance and Disambiguation for Chemical Data on the Biological Semantic Web journal October 2011
Extracting more value from data silos: using the semantic web to link chemistry and biology for innovation journal October 2013
Proactively designing nanomaterials to enhance performance and minimise hazard journal January 2008
Acute toxicity of 31 different nanoparticles to zebrafish (Danio rerio) tested in adulthood and in early life stages – comparative study journal June 2013
Nanoscale reference materials for environmental, health and safety measurements: needs, gaps and opportunities journal October 2012
The eNanoMapper database for nanomaterial safety information journal January 2015
The Nanomaterial Data Curation Initiative: A collaborative approach to assessing, evaluating, and advancing the state of the field journal January 2015
Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory journal January 2015
Nanocuration workflows: Establishing best practices for identifying, inputting, and sharing data to inform decisions on nanomaterials journal January 2015
An ISA-TAB-Nano based data collection framework to support data-driven modelling of nanotoxicology journal January 2015
Current situation on the availability of nanostructure–biological activity data dataset January 2015

Cited By (11)

Contribution of mesocosm testing to a single-step and exposure-driven environmental risk assessment of engineered nanomaterials journal January 2019
Harmonizing across environmental nanomaterial testing media for increased comparability of nanomaterial datasets journal January 2020
Practices and Trends of Machine Learning Application in Nanotoxicology journal January 2020
Toward Rigorous Materials Production: New Approach Methodologies Have Extensive Potential to Improve Current Safety Assessment Practices journal January 2020
Computational Design of Nucleic Acid-Based Bioreceptor for Contaminants of Emerging Concern book October 2019
A One Health approach to managing the applications and implications of nanotechnologies in agriculture journal June 2019
Best practices from nano-risk analysis relevant for other emerging technologies journal November 2019
Fifteen years of nanoEHS research advances science and fosters a vibrant community journal November 2019
Nanotoxicology data for in silico tools: a literature review journal February 2020
Building an International Consensus on Multi-Disciplinary Metadata Standards: A CODATA Case History in Nanotechnology journal January 2019
A Method for Extending Ontologies with Application to the Materials Science Domain journal January 2019

Similar Records

Integration among databases and data sets to support productive nanotechnology: Challenges and recommendations
Journal Article · Sun Dec 31 23:00:00 EST 2017 · NanoImpact · OSTI ID:1439666

Standardizng Data
Journal Article · Mon Feb 04 23:00:00 EST 2013 · Nature Nanotechnology, 8(2):73-74 · OSTI ID:1063695

ISA-TAB-Nano: A Specification for Sharing Nanomaterial Research Data in Spreadsheet-based Format
Journal Article · Sun Jan 13 19:00:00 EST 2013 · BMC Biotechnology (Online) · OSTI ID:1626537