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Title: Methods for delineating cellular regions and classifying regions of histopathology and microanatomy

Patent ·
OSTI ID:1735267
; ;

Embodiments disclosed herein provide methods and systems for delineating cell nuclei and classifying regions of histopathology or microanatomy while remaining invariant to batch effects. These systems and methods can include providing a plurality of reference images of histology sections. A first set of basis functions can then be determined from the reference images. Then, the histopathology or microanatomy of the histology sections can be classified by reference to the first set of basis functions, or reference to human engineered features. A second set of basis functions can then be calculated for delineating cell nuclei from the reference images and delineating the nuclear regions of the histology sections based on the second set of basis functions.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE; National Institutes of Health (NIH)
DOE Contract Number:
AC02-05CH11231; CA1437991; CA140663
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
10,776,606
Application Number:
14/493,208
OSTI ID:
1735267
Resource Relation:
Patent File Date: 09/22/2014
Country of Publication:
United States
Language:
English

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59 BASIC BIOLOGICAL SCIENCES