Correction of Q Factor Effects for Simultaneous Collection of Elemental Analysis and Relaxation Times by Nuclear Magnetic Resonance

Widgeon Paisner, Scarlett; Janicke, Michael Timothy; Kaseman, Derrick C.; Frankle, Rachel K.; Yoder, Jacob Luther; Alvarez, Marc Anthony; Espy, Michelle A.; Williams, Robert F.

doi:10.1021/acs.analchem.9b05603

Correction of Q Factor Effects for Simultaneous Collection of Elemental Analysis and Relaxation Times by Nuclear Magnetic Resonance

Journal Article · Mon Apr 27 00:00:00 EDT 2020 · Analytical Chemistry

DOI:https://doi.org/10.1021/acs.analchem.9b05603· OSTI ID:1734715

^[1]; ^[1]; ^[1]; Frankle, Rachel K. ^[1]; ^[1]; ^[1]; ^[1]; ^[1]

Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

A new method for measurement of elemental analysis by nuclear magnetic resonance (NMR) of unknown samples is discussed in this report as a quick and robust means to measure elemental ratios without the use of internal or external calibration standards. The determination of elemental ratios was done by normalizing the signal intensities by the frequency dependent quality factor (Q) and the gyromagnetic ratios (γ) for each measured nucleus. The correction for the frequency dependence was found by characterizing the output signal of the probe as a function of the quality factor (Q) and the frequency, and the correction for γ was discussed in a previous study. A Carr–Purcell–Meiboom–Gill (CPMG) pulse sequence was used for evaluation of the relative signal intensities, which allows for derivation of elemental ratios, and was correspondingly used to simultaneously measure the T₂* of samples for an added parameter for more accurate identification of unknown samples.

View Accepted Manuscript (DOE)

Research Organization:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE; US Department of Homeland Security (DHS)

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 1734715

Report Number(s):: LA-UR--19-26783

Journal Information:: Analytical Chemistry, Journal Name: Analytical Chemistry Journal Issue: 10 Vol. 92; ISSN 0003-2700

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

References (19)

Quantitation and characterization of process impurities and extractables in protein-containing solutions using proton NMR as a general tool Skidmore, Ken; Hewitt, Daniel; Kao, Yung-Hsiang Biotechnology Progress, Vol. 28, Issue 6 https://doi.org/10.1002/btpr.1620	journal	November 2012
13C and1H NMR investigations of quinic acid derivatives: Complete spectral assignment and elucidation of preferred conformations Flores-Parra, Angelina; Gutiérrez-Avella, Dora Marina; Contreras, Rosalinda Magnetic Resonance in Chemistry, Vol. 27, Issue 6 https://doi.org/10.1002/mrc.1260270607	journal	June 1989
Perfusion imaging with NMR contrast agents Rosen, Bruce R.; Belliveau, John W.; Vevea, James M. Magnetic Resonance in Medicine, Vol. 14, Issue 2 https://doi.org/10.1002/mrm.1910140211	journal	May 1990
Improving NMR sensitivity by use of salt-tolerant cryogenically cooled probes Robosky, Lora C.; Reily, Michael D.; Avizonis, Daina Analytical and Bioanalytical Chemistry, Vol. 387, Issue 2 https://doi.org/10.1007/s00216-006-0982-4	journal	November 2006
NMR-based metabolomics at work in phytochemistry Verpoorte, R.; Choi, Y. H.; Kim, H. K. Phytochemistry Reviews, Vol. 6, Issue 1 https://doi.org/10.1007/s11101-006-9031-3	journal	February 2007
Improved quantification from 1H-NMR spectra using reduced repetition times Bharti, Santosh Kumar; Sinha, Neeraj; Joshi, Bhawani Shankar Metabolomics, Vol. 4, Issue 4 https://doi.org/10.1007/s11306-008-0130-6	journal	September 2008
The signal-to-noise ratio of the nuclear magnetic resonance experiment Hoult, D. I.; Richards, R. E. Journal of Magnetic Resonance (1969), Vol. 24, Issue 1, p. 71-85 https://doi.org/10.1016/0022-2364(76)90233-X	journal	October 1976
Radiofrequency losses in NMR experiments on electrically conducting samples Gadian, D. G.; Robinson, F. N. H. Journal of Magnetic Resonance (1969), Vol. 34, Issue 2 https://doi.org/10.1016/0022-2364(79)90023-4	journal	May 1979
The detection and estimation of the relative amounts of primary and secondary hydroxyl groups using N.M.R. Mathias, A. Analytica Chimica Acta, Vol. 31 https://doi.org/10.1016/S0003-2670(00)88882-0	journal	January 1964
The depletion of protein signals in metabonomics analysis with the WET–CPMG pulse sequence Van, Que N.; Chmurny, Gwendolyn N.; Veenstra, Timothy D. Biochemical and Biophysical Research Communications, Vol. 301, Issue 4 https://doi.org/10.1016/S0006-291X(03)00079-2	journal	February 2003
Optimal electric fields for different sample shapes in high resolution NMR spectroscopy de Swiet, Thomas M. Journal of Magnetic Resonance, Vol. 174, Issue 2 https://doi.org/10.1016/j.jmr.2005.02.007	journal	June 2005
Elemental analysis by NMR Takeda, Kazuyuki; Ichijo, Naoki; Noda, Yasuto Journal of Magnetic Resonance, Vol. 224 https://doi.org/10.1016/j.jmr.2012.09.004	journal	November 2012
Concentration Measurement by Proton NMR Using the ERETIC Method Akoka, Serge; Barantin, Laurent; Trierweiler, Michel Analytical Chemistry, Vol. 71, Issue 13 https://doi.org/10.1021/ac981422i	journal	July 1999
Identification by NMR Spectroscopy of the Two Stereoisomers of the Platinum Complex [PtCl ₂ ( S -ahaz)] ( S -ahaz = 3( S )-Aminohexahydroazepine) Bound to a DNA 14-mer Oligonucleotide. NMR Evidence of Structural Alteration of a Platinated A·T-rich 14-mer DNA Duplex Diakos, Connie I.; Messerle, Barbara A.; del Socorro Murdoch, P. Inorganic Chemistry, Vol. 48, Issue 7 https://doi.org/10.1021/ic802207m	journal	March 2009
Modified Spin‐Echo Method for Measuring Nuclear Relaxation Times Meiboom, S.; Gill, D. Review of Scientific Instruments, Vol. 29, Issue 8 https://doi.org/10.1063/1.1716296	journal	August 1958
Limits of measurement in magnetic resonance Hill, H. D. W.; Richards, R. E. Journal of Physics E: Scientific Instruments, Vol. 1, Issue 10 https://doi.org/10.1088/0022-3735/1/10/202	journal	October 1968
Effects of Diffusion on Free Precession in Nuclear Magnetic Resonance Experiments Carr, H. Y.; Purcell, E. M. Physical Review, Vol. 94, Issue 3 https://doi.org/10.1103/PhysRev.94.630	journal	May 1954
Design procedure for permanent magnet assemblies with uniform magnetic fields for MRI devices Podol'skii, A. IEEE Transactions on Magnetics, Vol. 36, Issue 2 https://doi.org/10.1109/20.825819	journal	March 2000
Applications of solid-state NMR to pharmaceutical polymorphism and related matters* Harris, Robin K. Journal of Pharmacy and Pharmacology, Vol. 59, Issue 2 https://doi.org/10.1211/jpp.59.2.0009	journal	February 2007

Similar Records

Nuclear magnetic resonance pulse sequences for use with borehole logging tools

Patent · Tue Jun 11 00:00:00 EDT 1991 · OSTI ID:6006999

The effect of diffusion in internal gradients on nuclear magnetic resonance transverse relaxation measurements

Journal Article · Tue Nov 12 23:00:00 EST 2013 · AIP Conference Proceedings · OSTI ID:22257173

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
calibration
elemental analysis
magnetic properties
nuclear magnetic resonance
nuclear magnetic resonance spectroscopy
polarity
probes

Correction of Q Factor Effects for Simultaneous Collection of Elemental Analysis and Relaxation Times by Nuclear Magnetic Resonance

Citation Formats

References (19)

Similar Records

Related Subjects