The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association

Suslova, Klara G.; Efimov, Alexander V.; Sokolova, Alexandra B.; Napier, Bruce A.; Miller, Scott C.

doi:10.1371/journal.pone.0242151

The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association

Journal Article · Thu Nov 12 23:00:00 EST 2020 · PLoS ONE

DOI:https://doi.org/10.1371/journal.pone.0242151· OSTI ID:1721689

Suslova, Klara G. ^[1]; Efimov, Alexander V. ^[1]; Sokolova, Alexandra B. ^[1]; ^[2]; Miller, Scott C. ^[3]

Southern Urals Biophysics Institute (SUBI), Ozyorsk, (Russian Federation)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Univ. of Utah, Salt Lake City, UT (United States)

The radiochemical analysis of plutonium activity in urine is the main method for indirect estimation of doses of internal exposure from plutonium incorporation in professional workers. It was previously shown that late-in-life acute diseases, particularly those that affect the liver, can promote accelerated rates of release of plutonium from the liver with enhanced excretion rates. This initial study examines the relationships of some chronic diseases on plutonium excretion as well as the terminal relative distribution of plutonium between the liver and skeleton. Fourteen cases from former workers at the Mayak Production Association (Mayak PA) who provided from 4–9 urine plutonium bioassays for plutonium, had an autopsy conducted after death, and had sufficient clinical records to document their health status were used in this study. Enhanced plutonium excretion was associated with more serious chronic diseases, including cardiovascular diseases and other diseases that involved the liver. These chronic diseases were also associated with relatively less plutonium found in the liver relative to the skeleton determined by analyses conducted after autopsy. These data further document health conditions that affect plutonium biokinetics and organ deposition and retention patterns and suggest that health status should be considered when conducting plutonium bioassays as these may alter subsequent dosimetry and risk models.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Environment, Health, Safety and Security (AU); Federal Medical Biological Agency of the Russian Federation

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1721689

Report Number(s):: PNNL-SA--126480

Journal Information:: PLoS ONE, Journal Name: PLoS ONE Journal Issue: 11 Vol. 15; ISSN 1932-6203

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

References (32)

A scintillation method for determination of actinide alpha-activity in samples Khokhryakov, V. F.; Kudravtseva, T. I.; Chernikov, V. I. Journal of Radioanalytical and Nuclear Chemistry, Vol. 234, Issue 1-2 https://doi.org/10.1007/bf02389788	journal	August 1998
Evaluation of tissue metal and trace element content in a rat model of non-alcoholic fatty liver disease using ICP-DRC-MS Gatiatulina, Eugenia R.; Popova, Elizaveta V.; Polyakova, Valentina S. Journal of Trace Elements in Medicine and Biology, Vol. 39 https://doi.org/10.1016/j.jtemb.2016.08.007	journal	January 2017
Effect of ethanol on the retention of americium‐241 in the baboon liver Cohen, Norman; Antonelli, Richard; Lo Sasso, Thomas Journal of Toxicology and Environmental Health, Vol. 4, Issue 5-6 https://doi.org/10.1080/15287397809529703	journal	January 1978
The effect of state of health on organ distribution and excretion of systemic plutonium in the Mayak workers G. Suslova, K.; F. Khokhryakov, V.; B. Tokarskaya, Z. Radiation Protection Dosimetry, Vol. 105, Issue 1-4 https://doi.org/10.1093/oxfordjournals.rpd.a006228	journal	July 2003
Multiparameter Analysis of Fall-Out Plutonium Burdens in Human Liver Griffith, W. C.; Guilmette, R. A. Radiation Protection Dosimetry, Vol. 38, Issue 1-3 https://doi.org/10.1093/oxfordjournals.rpd.a081079	journal	September 1991
Comparison of Systemic Plutonium Deposition Estimates from Urinalysis and Autopsy Data in Five Whole-body Donors Kathren, Ronald L.; McInroy, James F. Health Physics, Vol. 60, Issue 4 https://doi.org/10.1097/00004032-199104000-00001	journal	January 1991
Metabolism and Dosimetry of Actinide Elements in Occupationally-Exposed Personnel of Russia and the United States: a Summary Progress Report Khokhryakov, Valentin F.; Suslova, Klara G.; Filipy, Ronald E. Health Physics, Vol. 79, Issue 1 https://doi.org/10.1097/00004032-200007000-00011	journal	January 2000
Extrapulmonary Organ Distribution of Plutonium in Healthy Workers Exposed by Chronic Inhalation at the Mayak Production Association Suslova, K. G.; Khokhryakov, V. F.; Tokarskaya, Z. B. Health Physics, Vol. 82, Issue 4 https://doi.org/10.1097/00004032-200204000-00002	journal	January 2002
Modifying Effects of Health Status, Physiological, and Dosimetric Factors on Extrapulmonary Organ Distribution and Excretion of Inhaled Plutonium in Workers at the Mayak Production Association Suslova, K. G.; Khokhryakov, V. F.; Tokarskaya, Z. B. Health Physics, Vol. 90, Issue 4 https://doi.org/10.1097/01.hp.0000183759.39785.9c	journal	January 2006
Mayak Worker Dosimetry Study: an Overview Vasilenko, E. K.; Khokhryakov, V. F.; Miller, S. C. Health Physics, Vol. 93, Issue 3 https://doi.org/10.1097/01.hp.0000266071.43137.0e	journal	January 2007
Radiation Risk of Malignant Neoplasms in Organs of Main Deposition for Plutonium in the Cohort of Mayak Workers with Regard to Histological Types Labutina, E. V.; Kuznetsova, I. S.; Hunter, N. Health Physics, Vol. 105, Issue 2 https://doi.org/10.1097/hp.0b013e31828f57df	journal	January 2013
When the heart kills the liver: acute liver failure in congestive heart failure Saner, Fh; Heuer, M.; Meyer, M. European Journal of Medical Research, Vol. 14, Issue 12 https://doi.org/10.1186/2047-783x-14-12-541	journal	December 2009
Bone Cancers in Mayak Workers Koshurnikova, N. A.; Gilbert, E. S.; Sokolnikov, M. Radiation Research, Vol. 154, Issue 3 https://doi.org/10.1667/0033-7587(2000)154[0237:bcimw]2.0.co;2	journal	September 2000
Liver Cancers in Mayak Workers Gilbert, E. S.; Koshurnikova, N. A.; Sokolnikov, M. Radiation Research, Vol. 154, Issue 3 https://doi.org/10.1667/0033-7587(2000)154[0246:lcimw]2.0.co;2	journal	September 2000
Lung, liver and bone cancer mortality in Mayak workers: Mortality in Mayak Workers Sokolnikov, Mikhail E.; Gilbert, Ethel S.; Preston, Dale L. International Journal of Cancer, Vol. 123, Issue 4 https://doi.org/10.1002/ijc.23581	journal	June 2008
Analysis for actinides in tissue samples from plutonium workers of two countries Filipy, R. E.; Khokhryakov, V. F.; Suslova, K. G. Journal of Radioanalytical and Nuclear Chemistry, Vol. 234, Issue 1-2 https://doi.org/10.1007/BF02389767	journal	August 1998
A scintillation method for determination of actinide alpha-activity in samples Khokhryakov, V. F.; Kudravtseva, T. I.; Chernikov, V. I. Journal of Radioanalytical and Nuclear Chemistry, Vol. 234, Issue 1-2 https://doi.org/10.1007/BF02389788	journal	August 1998
Comparison of the Dosimetry Registry of the Mayak Industrial Association and the United States Transuranium and Uranium Registries: A Preliminary Report Suslova, K. G.; Filipy, R. E.; Khokhryakov, V. F. Radiation Protection Dosimetry, Vol. 67, Issue 1 https://doi.org/10.1093/oxfordjournals.rpd.a031791	journal	July 1996
Plutonium Excretion Model for the Healthy Man Khokhryakov, V. F.; Menshikh, Z. S.; Suslova, K. G. Radiation Protection Dosimetry, Vol. 53, Issue 1-4 https://doi.org/10.1093/rpd/53.1-4.235	journal	May 1994
The Mayak Worker Dosimetry System (Mwds-2013) for Internally Deposited Plutonium: an Overview Birchall, A.; Vostrotin, V.; Puncher, M. Radiation Protection Dosimetry, Vol. 176, Issue 1-2 https://doi.org/10.1093/rpd/ncx014	journal	February 2017
Distribution of Fallout Plutonium in Southern Finns Mussalo, Helena; Jaakkola, T.; Miettinen, J. K. Health Physics, Vol. 39, Issue 2 https://doi.org/10.1097/00004032-198008000-00011	journal	January 1980
Promotion of Radiation-induced Liver Neoplasia by Ethanol Taylor, Glenn N.; Lloyd, Ray D.; Mays, Charles W. Health Physics, Vol. 62, Issue 2 https://doi.org/10.1097/00004032-199202000-00008	journal	January 1992
Modifying Effects of Health Status, Physiological, and Dosimetric Factors on Extrapulmonary Organ Distribution and Excretion of Inhaled Plutonium in Workers at the Mayak Production Association Suslova, K. G.; Khokhryakov, V. F.; Tokarskaya, Z. B. Health Physics, Vol. 90, Issue 4 https://doi.org/10.1097/01.HP.0000183759.39785.9c	journal	January 2006
Mayak Worker Dosimetry Study: an Overview Vasilenko, E. K.; Khokhryakov, V. F.; Miller, S. C. Health Physics, Vol. 93, Issue 3 https://doi.org/10.1097/01.HP.0000266071.43137.0e	journal	January 2007
Mayak Worker Dosimetry System 2008 (MWDS-2008): Assessment of Internal Dose from Measurement Results of Plutonium Activity in Urine Khokhryakov, Victor V.; Khokhryakov, Valentin F.; Suslova, Klara G. Health Physics, Vol. 104, Issue 4 https://doi.org/10.1097/HP.0b013e31827dbf60	journal	January 2013
Radiation Risk of Malignant Neoplasms in Organs of Main Deposition for Plutonium in the Cohort of Mayak Workers with Regard to Histological Types Labutina, E. V.; Kuznetsova, I. S.; Hunter, N. Health Physics, Vol. 105, Issue 2 https://doi.org/10.1097/HP.0b013e31828f57df	journal	January 2013
When the heart kills the liver: acute liver failure in congestive heart failure Saner, Fh; Heuer, M.; Meyer, M. European Journal of Medical Research, Vol. 14, Issue 12 https://doi.org/10.1186/2047-783X-14-12-541	journal	December 2009
Radiation Effects on Mortality from Solid Cancers Other than Lung, Liver, and Bone Cancer in the Mayak Worker Cohort: 1948–2008 Sokolnikov, Mikhail; Preston, Dale; Gilbert, Ethel PLOS ONE, Vol. 10, Issue 2 https://doi.org/10.1371/journal.pone.0117784	journal	February 2015
Bone Cancers in Mayak Workers Koshurnikova, N. A.; Gilbert, E. S.; Sokolnikov, M. Radiation Research, Vol. 154, Issue 3 https://doi.org/10.1667/0033-7587(2000)154[0237:BCIMW]2.0.CO;2	journal	September 2000
Liver Cancers in Mayak Workers Gilbert, E. S.; Koshurnikova, N. A.; Sokolnikov, M. Radiation Research, Vol. 154, Issue 3 https://doi.org/10.1667/0033-7587(2000)154[0246:LCIMW]2.0.CO;2	journal	September 2000
Lung Cancer Risks from Plutonium: An Updated Analysis of Data from the Mayak Worker Cohort Gilbert, E. S.; Sokolnikov, M. E.; Preston, D. L. Radiation Research, Vol. 179, Issue 3 https://doi.org/10.1667/RR3054.1	journal	February 2013
Relationship between Heart Disease and Liver Disease: A Two-Way Street El Hadi, Hamza; Di Vincenzo, Angelo; Vettor, Roberto Cells, Vol. 9, Issue 3 https://doi.org/10.3390/cells9030567	journal	February 2020

Similar Records

URINARY EXCRETION OF PLUTONIUM IN MAYAK WORKERS DURING AND AFTER CA-DTPA ADMINISTRATION

Journal Article · Tue Nov 30 23:00:00 EST 2021 · Radiation Protection Dosimetry · OSTI ID:1982721

Metabolism and dosimetry of actinide elements in occupationally-exposed personnel of Russia and the United States: A summary progress report

Journal Article · Sat Jul 01 00:00:00 EDT 2000 · Health Physics · OSTI ID:20080417

Mayak worker dosimetry study: An overview

Journal Article · Sat Sep 01 00:00:00 EDT 2007 · Health Physics, 93(3):190-206 · OSTI ID:921253

Related Subjects

60 APPLIED LIFE SCIENCES
biokinetics
bones
liver disease
plutonium
urinary excretion

The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association

Citation Formats

References (32)

Similar Records

Related Subjects