Engineering Organization of DNA Nano-Chambers through Dimensionally Controlled and Multi-Sequence Encoded Differentiated Bonds

Lin, Zhiwei; Emamy, Hamed; Minevich, Brian; Xiong, Yan; Xiang, Shuting; Kumar, Sanat; Ke, Yonggang; Gang, Oleg

doi:10.1021/jacs.0c07263

Title: Engineering Organization of DNA Nano-Chambers through Dimensionally Controlled and Multi-Sequence Encoded Differentiated Bonds

Journal Article · Wed Sep 09 00:00:00 EDT 2020 · Journal of the American Chemical Society

DOI:https://doi.org/10.1021/jacs.0c07263· OSTI ID:1716753

Lin, Zhiwei ^[1]; Emamy, Hamed ^[1]; Minevich, Brian ^[1]; Xiong, Yan ^[1]; Xiang, Shuting ^[1]; Kumar, Sanat ^[1]; Ke, Yonggang ^[2];

^[3]

Columbia Univ., New York, NY (United States)
Emory Univ., Atlanta, GA (United States); Georgia Inst. of Technology, Atlanta, GA (United States)
Columbia Univ., New York, NY (United States); Brookhaven National Lab. (BNL), Upton, NY (United States). Center for Functional Nanomaterials (CFN)

Engineering the assembly of nanoscale objects into complex and prescribed structures requires control over their binding properties. Additionally, such control might benefit from a well-defined bond directionality, the ability to designate their engagements through specific encodings, and the capability to coordinate local orientations. Although much progress has been achieved in our ability to design complex nano-objects, the challenges in creating such nano-objects with fully controlled binding modes and understanding their fundamental properties are still outstanding. Here, we report a facile strategy for creating a DNA nanochamber (DNC), a hollow cuboid nano-object, whose bonds can be fully prescribed and complexly encoded along its three orthogonal axes, giving rise to addressable and differentiated bonds. The DNC can host nanoscale cargoes, which allows for the integration with functional nano-objects and their organization in larger-scale systems. We explore the relationship between the design of differentiated bonds and a formation of one-(1D), two-(2D), and three-(3D) dimensional organized arrays. Through the realization of different binding modes, we demonstrate sequence encoded nanoscale heteropolymers, helical polymers, 2D lattices, and mesoscale 3D nanostructures with internal order, and show that this assembly strategy can be applied for the organization of nanoparticles. Overall, we combine experimental investigations with computational simulation to understand the mechanism of structural formation for different types of ordered arrays, and to correlate the bonds design with assembly processes.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0012704; SC0008772

OSTI ID:: 1716753

Report Number(s):: BNL-220598-2020-JAAM

Journal Information:: Journal of the American Chemical Society, Vol. 142, Issue 41; ISSN 0002-7863

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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