Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Beam characterization at NSRL for radiobiological experiments—phase 1

Journal Article · · Journal of Instrumentation
 [1];  [1];  [2];  [3];  [3];  [3];  [4];  [1]
  1. German Cancer Research Center (DKFZ), Heidelberg (Germany); Heidelberg Inst. for Radiation Oncology (HIRO), Heidelberg (Germany)
  2. German Cancer Research Center (DKFZ), Heidelberg (Germany); Heidelberg Inst. for Radiation Oncology (HIRO), Heidelberg (Germany); Heidelberg Ion-Beam Therapy Centre (HIT), Heidelberg (Germany)
  3. Brookhaven National Lab. (BNL), Upton, NY (United States). NASA Space Radiation Lab. (NSRL)
  4. National Inst. of Health (NIH), Bethesda, MD (United States)
An experimental campaign was carried out at the NASA Space Radiation Laboratory to perform an additional, independent dosimetric characterization of the beams of protons, helium and carbon ions for radiobiological experiments. The campaign was undertaken by the request and with the support from the National Cancer Institute, U.S. In this initial phase, the goals were to obtain a first assessment of the dosimetric reproducibility of the beam control system, including analysis of spatial homogeneity and evaluation of ion beam contamination. They should facilitate the design of further experimental campaigns for beam characterization for radiobiological experiments. Measurements included reference dosimetry with comparison of in-house and external ionization chambers and electrometers, lateral-dose profile measurements in air, depth-dose profile in a water tank, evaluation of water equivalent thickness of a HDPE binary range shifter and estimation of impurities of the investigated helium-ion beam. The experiments and results are presented.
Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Nuclear Physics (NP); National Aeronautic and Space Administration (NASA)
Grant/Contract Number:
SC0012704; AC02-98CH10886
OSTI ID:
1706613
Alternate ID(s):
OSTI ID: 23037114
Report Number(s):
BNL--220560-2020-JAAM
Journal Information:
Journal of Instrumentation, Journal Name: Journal of Instrumentation Journal Issue: 10 Vol. 15; ISSN 1748-0221
Publisher:
Institute of Physics (IOP)Copyright Statement
Country of Publication:
United States
Language:
English

References (22)

Zur Theorie des Durchgangs schneller Korpuskularstrahlen durch Materie journal January 1930
Proof of principle of helium-beam radiography using silicon pixel detectors for energy deposition measurement, identification, and tracking of single ions journal January 2018
Report of a National Cancer Institute special panel: Characterization of the physical parameters of particle beams for biological research journal December 2018
A Dose of Reality: How 20 Years of Incomplete Physics and Dosimetry Reporting in Radiobiology Studies May Have Contributed to the Reproducibility Crisis journal February 2020
A semiconductor radiation imaging pixel detector for space radiation dosimetry journal July 2015
Twenty years of space radiation physics at the BNL AGS and NASA Space Radiation Laboratory journal June 2016
Overview of the NASA space radiation laboratory journal November 2016
Timepix, a 65k programmable pixel readout chip for arrival time, energy and/or photon counting measurements
  • Llopart, X.; Ballabriga, R.; Campbell, M.
  • Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 581, Issue 1-2 https://doi.org/10.1016/j.nima.2007.08.079
journal October 2007
Timepix-based radiation environment monitor measurements aboard the International Space Station
  • Stoffle, Nicholas; Pinsky, Lawrence; Kroupa, Martin
  • Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 782 https://doi.org/10.1016/j.nima.2015.02.016
journal May 2015
Asic developments for radiation imaging applications: The medipix and timepix family
  • Ballabriga, Rafael; Campbell, Michael; Llopart, Xavier
  • Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 878 https://doi.org/10.1016/j.nima.2017.07.029
journal January 2018
The SATRAM Timepix spacecraft payload in open space on board the Proba-V satellite for wide range radiation monitoring in LEO orbit journal June 2016
Non-invasive monitoring of therapeutic carbon ion beams in a homogeneous phantom by tracking of secondary ions journal May 2013
Fragmentation of 120 and 200 MeV u −1 4 He ions in water and PMMA targets journal January 2017
Investigation of mixed ion fields in the forward direction for 220.5 MeV/u helium ion beams: comparison between water and PMMA targets journal October 2017
Investigation of single carbon ion fragmentation in water and PMMA for hadron therapy journal March 2019
Experimental verification of a non-invasive method to monitor the lateral pencil beam position in an anthropomorphic phantom for carbon-ion radiotherapy journal September 2019
Impact of new ICRU 90 key data on stopping-power ratios and beam quality correction factors for carbon ion beams journal September 2019
Energy deposition measurements of single 1 H, 4 He and 12 C ions of therapeutic energies in a silicon pixel detector journal April 2017
Measurement of He 4 charge- and mass-changing cross sections on H, C, O, and Si targets in the energy range 70–220 MeV/u for radiation transport calculations in ion-beam therapy journal January 2019
Review of Particle Physics journal August 2018
Use of the NASA Space Radiation Laboratory at Brookhaven National Laboratory to Conduct Charged Particle Radiobiology Studies Relevant to Ion Therapy journal June 2016
Range Verification Methods in Particle Therapy: Underlying Physics and Monte Carlo Modeling journal July 2015

Similar Records

Iron Beam Characterization Studies at NSRL
Technical Report · Sun Jan 31 23:00:00 EST 2010 · OSTI ID:1775548

Quantitative concepts and dosimetry in radiobiology
Book · Sun Dec 31 23:00:00 EST 1978 · OSTI ID:5686234

Molecular and cellular radiobiology of heavy ions
Journal Article · Tue Nov 30 23:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:5145808