The heart as an extravascular target of endothelin-1 in particulate matter-induced cardiac dysfunction

Chan, Elizabeth A. W.; Buckley, Barbara; Farraj, Aimen K.; Thompson, Leslie C.

doi:10.1016/j.pharmthera.2016.05.006

The heart as an extravascular target of endothelin-1 in particulate matter-induced cardiac dysfunction

Journal Article · Thu Sep 01 00:00:00 EDT 2016 · Pharmacology and Therapeutics

DOI:https://doi.org/10.1016/j.pharmthera.2016.05.006· OSTI ID:1702545

Chan, Elizabeth A. W.; Buckley, Barbara; Farraj, Aimen K.; Thompson, Leslie C.

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Sponsoring Organization:: USDOE

OSTI ID:: 1702545

Journal Information:: Pharmacology and Therapeutics, Journal Name: Pharmacology and Therapeutics Journal Issue: C Vol. 165; ISSN 0163-7258

Publisher:: ElsevierCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (218)

Ambient Air Pollution and the Risk of Acute Ischemic Stroke Wellenius, Gregory A. Archives of Internal Medicine, Vol. 172, Issue 3 https://doi.org/10.1001/archinternmed.2011.732	journal	February 2012
Fine Particulate Air Pollution and Hospital Admission for Cardiovascular and Respiratory Diseases Dominici, Francesca; Peng, Roger D.; Bell, Michelle L. JAMA, Vol. 295, Issue 10 https://doi.org/10.1001/jama.295.10.1127	journal	March 2006
Safety, tolerability, pharmacokinetics, and pharmacodynamics of macitentan, an endothelin receptor antagonist, in an ascending multiple‐dose study in healthy subjects Sidharta, Patricia N.; van Giersbergen, Paul L. M.; Dingemanse, Jasper The Journal of Clinical Pharmacology, Vol. 53, Issue 11 https://doi.org/10.1002/jcph.152	journal	September 2013
Critical Factors in the Radioimmunoassay of Endothelin-1, Endothelin-3, and Big Endothelin-1 in Human Plasma Shaw, Sidney G.; Schmid, Michael; Casty, Adriano Analytical Biochemistry, Vol. 278, Issue 2 https://doi.org/10.1006/abio.1999.4451	journal	February 2000
Signaling Pathways Crucial for Craniofacial Development Revealed by Endothelin-A Receptor-Deficient Mice Clouthier, David E.; Williams, S. Clay; Yanagisawa, Hiromi Developmental Biology, Vol. 217, Issue 1 https://doi.org/10.1006/dbio.1999.9527	journal	January 2000
Endothelin-1 Gene Suppression by Shear Stress: Pharmacological Evaluation of the Role of Tyrosine Kinase, Intracellular Calcium, Cytoskeleton, and Mechanosensitive Channels Malek, Adel M.; Zhang, Janet; Jiang, Jianwei Journal of Molecular and Cellular Cardiology, Vol. 31, Issue 2 https://doi.org/10.1006/jmcc.1998.0873	journal	February 1999
Elevated endothelin 1 levels in critical illness Haak, T.; Jungmann, E.; Kasper-Dahm, G. The Clinical Investigator, Vol. 72, Issue 3 https://doi.org/10.1007/BF00189316	journal	February 1994
Extrapulmonary translocation of intratracheally instilled fine and ultrafine particles via direct and alveolar macrophage-associated routes Furuyama, Akiko; Kanno, Sanae; Kobayashi, Takahiro Archives of Toxicology, Vol. 83, Issue 5 https://doi.org/10.1007/s00204-008-0371-1	journal	October 2008
Macitentan: entry-into-humans study with a new endothelin receptor antagonist Sidharta, Patricia N.; van Giersbergen, Paul L. M.; Halabi, Atef European Journal of Clinical Pharmacology, Vol. 67, Issue 10 https://doi.org/10.1007/s00228-011-1043-2	journal	May 2011
Novel aspects of excitation–contraction coupling in heart failure Neef, Stefan; Maier, Lars S. Basic Research in Cardiology, Vol. 108, Issue 4 https://doi.org/10.1007/s00395-013-0360-2	journal	June 2013
Heart rate variability, hemostatic and acute inflammatory blood parameters in healthy adults after short-term exposure to welding fume Scharrer, E.; Hessel, H.; Kronseder, A. International Archives of Occupational and Environmental Health, Vol. 80, Issue 4 https://doi.org/10.1007/s00420-006-0127-2	journal	June 2006
Chemical composition of ambient particulate matter and redox activity Jeng, Hueiwang Anna Environmental Monitoring and Assessment, Vol. 169, Issue 1-4 https://doi.org/10.1007/s10661-009-1199-8	journal	November 2009
Endothelin and the production of cerebral vasospasm in dogs Asano, Toshio; Ikegaki, Ichiro; Suzuki, Yoshio Biochemical and Biophysical Research Communications, Vol. 159, Issue 3 https://doi.org/10.1016/0006-291X(89)92258-4	journal	March 1989
An endothelin receptor (ETA) antagonist isolated from Streptomyces misakiensis Ihara, Masaki; Fukuroda, Takahiro; Saeki, Toshihiko Biochemical and Biophysical Research Communications, Vol. 178, Issue 1 https://doi.org/10.1016/0006-291X(91)91789-F	journal	July 1991
Endothelin-1 and platelet activating factor stimulate thromboxane A2 biosynthesis in rat vascular smooth muscle cells Miki, Takayasu-Okishio; Zen-Ichi, Terashita; Koichi, Kondo Biochemical Pharmacology, Vol. 40, Issue 12 https://doi.org/10.1016/0006-2952(90)90592-9	journal	December 1990
Regional vasodilation is a prominent feature of the haemodynamic response to endothelin in anaesthetized, spontaneously hypertensive rats Wright, Christine E.; Fozard, John R. European Journal of Pharmacology, Vol. 155, Issue 1-2 https://doi.org/10.1016/0014-2999(88)90425-6	journal	October 1988
Modified low density lipoproteins activate human macrophages to secrete immunoreactive endothelin Martin-Nizard, Françoise; Houssaini, Hayat Sqalli; Lestavel-Delattre, Sophie FEBS Letters, Vol. 293, Issue 1-2 https://doi.org/10.1016/0014-5793(91)81167-7	journal	November 1991
Conformational study of cyclo[D-Trp-D-Asp-Pro-D-Val-Leu], an endothelin-A receptor-selective antagonist Atkinson, R. Andrew; Pelton, John T. FEBS Letters, Vol. 296, Issue 1 https://doi.org/10.1016/0014-5793(92)80390-3	journal	January 1992
In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ET _A and ET _B receptors Breu, Volker; Löffler, Bernd-Michael; Clozel, Martine FEBS Letters, Vol. 334, Issue 2 https://doi.org/10.1016/0014-5793(93)81713-A	journal	November 1993
Endothelin release during ischaemia and reperfusion of isolated perfused rat hearts Brunner, F. Journal of Molecular and Cellular Cardiology, Vol. 24, Issue 11 https://doi.org/10.1016/0022-2828(92)93095-2	journal	November 1992
Biological profiles of highly potent novel endothelin antagonists selective for the ETA receptor Ihara, Masaki; Noguchi, Kazuhito; Saeki, Toshihiko Life Sciences, Vol. 50, Issue 4 https://doi.org/10.1016/0024-3205(92)90331-I	journal	January 1992
Analysis of responses to endothelins in isolated porcine blood vessels by using a novel endothelin antagonist, BQ-153 Fukuroda, Takahiro; Nishikibe, Masaru; Ohta, Yukari Life Sciences, Vol. 50, Issue 15 https://doi.org/10.1016/0024-3205(92)90353-Q	journal	January 1992
Endothelin plays a role in the maintenance of blood pressure in normotensive guinea pigs Véniant, Murielle; Clozel, Jean-Paul; Hess, Patrick Life Sciences, Vol. 55, Issue 6 https://doi.org/10.1016/0024-3205(94)90056-6	journal	January 1994
Baseline metal-in-dust concentrations in Greater London Schwar, M. J. R.; Moorcroft, J. S.; Laxen, D. P. H. Science of The Total Environment, Vol. 68 https://doi.org/10.1016/0048-9697(88)90359-2	journal	January 1988
Importance of secondary TXA2 release in mediating of endothelin-1 induced bronchoconstriction and vasopressin in the guinea-pig Lueddeckens, G.; Bigl, H.; Sperling, J. Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 48, Issue 3 https://doi.org/10.1016/0952-3278(93)90095-E	journal	March 1993
Peripheral edema Cho, Shaun; Atwood, J. Edwin The American Journal of Medicine, Vol. 113, Issue 7 https://doi.org/10.1016/S0002-9343(02)01322-0	journal	November 2002
Acute Effects of Inhaled Urban Particles and Ozone Bouthillier, Léo; Vincent, Renaud; Goegan, Patrick The American Journal of Pathology, Vol. 153, Issue 6 https://doi.org/10.1016/S0002-9440(10)65701-X	journal	December 1998
Endothelin stimulates phospholipase C in cultured vascular smooth muscle cells Resink, Thérèse J.; Scott-Burden, Timothy; Bühler, Fritz R. Biochemical and Biophysical Research Communications, Vol. 157, Issue 3 https://doi.org/10.1016/S0006-291X(88)81025-8	journal	December 1988
Endothelin receptors in adult human and swine isolated ventricular cardiomyocytes Modesti, Pietro Amedeo; Vanni, Simone; Paniccia, Rita Biochemical Pharmacology, Vol. 58, Issue 2 https://doi.org/10.1016/S0006-2952(99)00081-7	journal	July 1999
Endothelin and cardiac arrhythmias: do endothelin antagonists have a therapeutic potential as antiarrhythmic drugs? Duru, F. Cardiovascular Research, Vol. 49, Issue 2 https://doi.org/10.1016/S0008-6363(00)00263-7	journal	February 2001
Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-β1 and endothelin-1 from fibroblasts Gray, M. Cardiovascular Research, Vol. 40, Issue 2 https://doi.org/10.1016/S0008-6363(98)00121-7	journal	November 1998
Ventricular arrhythmias induced by endothelin-1 or by acute ischemia: a comparative analysis using three-dimensional mapping Becker, R. Cardiovascular Research, Vol. 45, Issue 2 https://doi.org/10.1016/S0008-6363(99)00362-4	journal	January 2000
Increases of vascular endothelin-converting enzyme activity and endothelin-1 level on atherosclerotic lesions in hyperlipidemic rabbits Mitani, Hironobu; Takimoto, Misato; Bandoh, Tsutomu European Journal of Pharmacology, Vol. 387, Issue 3 https://doi.org/10.1016/S0014-2999(99)00808-0	journal	January 2000
Enhanced vasoconstrictor effect of big endothelin-1 in patients with atherosclerosis: relation to conversion to endothelin-1 Böhm, Felix; Johansson, Bo-Lennart; Hedin, Ulf Atherosclerosis, Vol. 160, Issue 1 https://doi.org/10.1016/S0021-9150(01)00564-0	journal	January 2002
The Human Preproendothelin-1 Gene Inoue, A.; Yanagisawa, M.; Takuwa, Y. Journal of Biological Chemistry, Vol. 264, Issue 25 https://doi.org/10.1016/S0021-9258(18)63795-0	journal	September 1989
Investigating the dual nature of endothelin-1: Ischemia or direct arrhythmogenic effect? Szabó, Tamás; Gellér, László; Merkely, Béla Life Sciences, Vol. 66, Issue 26 https://doi.org/10.1016/S0024-3205(00)00587-7	journal	May 2000
Are nursery schools and kindergartens safe for our kids? The Hong Kong study Tong, Susanna T. Y.; Lam, Kin Che Science of The Total Environment, Vol. 216, Issue 3 https://doi.org/10.1016/S0048-9697(98)00161-2	journal	May 1998
Particulate matter in the atmosphere: which particle properties are important for its effects on health? Harrison, Roy M.; Yin, Jianxin Science of The Total Environment, Vol. 249, Issue 1-3 https://doi.org/10.1016/S0048-9697(99)00513-6	journal	April 2000
The Meuse Valley fog of 1930: an air pollution disaster Nemery, Benoit; Hoet, Peter HM; Nemmar, Abderrahim The Lancet, Vol. 357, Issue 9257 https://doi.org/10.1016/S0140-6736(00)04135-0	journal	March 2001
Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the Endothelin A Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial Anand, Inder; McMurray, John; Cohn, Jay N. The Lancet, Vol. 364, Issue 9431 https://doi.org/10.1016/S0140-6736(04)16723-8	journal	July 2004
Global association of air pollution and heart failure: a systematic review and meta-analysis Shah, Anoop SV; Langrish, Jeremy P.; Nair, Harish The Lancet, Vol. 382, Issue 9897 https://doi.org/10.1016/S0140-6736(13)60898-3	journal	September 2013
Contribution of endogenous generation of endothelin-1 to basal vascular tone Haynes, W. The Lancet, Vol. 344, Issue 8926 https://doi.org/10.1016/S0140-6736(94)92827-4	journal	September 1994
The human heart endothelin system: ET-1 synthesis, storage, release and effect Russell, F. Trends in Pharmacological Sciences, Vol. 21, Issue 9 https://doi.org/10.1016/S0165-6147(00)01524-8	journal	September 2000
Heavy metal levels and solid phase speciation in street dusts of Delhi, India Banerjee, Anju D. K. Environmental Pollution, Vol. 123, Issue 1 https://doi.org/10.1016/S0269-7491(02)00337-8	journal	May 2003
Tezosentan in patients with acuteheart failure and acute coronary syndromes O’Connor, Christopher M.; Gattis, Wendy A.; Adams, Kirkwood F. Journal of the American College of Cardiology, Vol. 41, Issue 9 https://doi.org/10.1016/S0735-1097(03)00194-3	journal	May 2003
Increased plasma endothelin-1 in the early hours of acute myocardial infarction Stewart, Duncan J.; Kubac, George; Costello, Kevin B. Journal of the American College of Cardiology, Vol. 18, Issue 1 https://doi.org/10.1016/S0735-1097(10)80214-1	journal	July 1991
Effects of Second-Hand Smoke and Gender on Infarct Size of Young Rats Exposed In Utero and in the Neonatal to Adolescent Period 11All editorial decisions for this article, including selection of referees, were made by a Guest Editor. This policy applies to all articles with authors from the University of California San Francisco. Zhu, Bo-Qing; Sun, Yi-Ping; Sudhir, Krishnankutty Journal of the American College of Cardiology, Vol. 30, Issue 7 https://doi.org/10.1016/S0735-1097(97)00364-1	journal	December 1997
Update of REACH-1 and MERIT-HF clinical trials in heart failure Mylona, Panayiota; Cleland, John G. F. European Journal of Heart Failure, Vol. 1, Issue 2 https://doi.org/10.1016/S1388-9842(99)00022-7	journal	June 1999
Relation of Long-Term Exposure to Air Pollution to Brachial Artery Flow-Mediated Dilation and Reactive Hyperemia Wilker, Elissa H.; Ljungman, Petter L.; Rice, Mary B. The American Journal of Cardiology, Vol. 113, Issue 12 https://doi.org/10.1016/j.amjcard.2014.03.048	journal	June 2014
Autonomic regulation of cellular immune function Bellinger, Denise L.; Lorton, Dianne Autonomic Neuroscience, Vol. 182 https://doi.org/10.1016/j.autneu.2014.01.006	journal	May 2014
Air Pollution and Cardiovascular Disease Franklin, Barry A.; Brook, Robert; Arden Pope, C. Current Problems in Cardiology, Vol. 40, Issue 5 https://doi.org/10.1016/j.cpcardiol.2015.01.003	journal	May 2015
Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression Thomson, Errol M.; Kumarathasan, Prem; Calderón-Garcidueñas, Lilian Environmental Research, Vol. 105, Issue 2 https://doi.org/10.1016/j.envres.2007.06.005	journal	October 2007
Mexico City normal weight children exposed to high concentrations of ambient PM2.5 show high blood leptin and endothelin-1, vitamin D deficiency, and food reward hormone dysregulation versus low pollution controls. Relevance for obesity and Alzheimer disease Calderón-Garcidueñas, Lilian; Franco-Lira, Maricela; D'Angiulli, Amedeo Environmental Research, Vol. 140 https://doi.org/10.1016/j.envres.2015.05.012	journal	July 2015
The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles Li, Ning; Xia, Tian; Nel, Andre E. Free Radical Biology and Medicine, Vol. 44, Issue 9 https://doi.org/10.1016/j.freeradbiomed.2008.01.028	journal	May 2008
Long-term endothelin receptor antagonism attenuates coronary plaque progression in patients with early atherosclerosis Yoon, Myeong Ho; Reriani, Martin; Mario, Gössl International Journal of Cardiology, Vol. 168, Issue 2 https://doi.org/10.1016/j.ijcard.2012.12.001	journal	September 2013
Vascular Responses to Long- and Short-Term Exposure to Fine Particulate Matter Krishnan, Ranjini M.; Adar, Sara D.; Szpiro, Adam A. Journal of the American College of Cardiology, Vol. 60, Issue 21 https://doi.org/10.1016/j.jacc.2012.08.973	journal	November 2012
Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models Hao, Minqi; Comier, Stephania; Wang, Meiying Journal of Allergy and Clinical Immunology, Vol. 112, Issue 5 https://doi.org/10.1016/j.jaci.2003.07.005	journal	November 2003
Particulate matter (PM10) exposure induces endothelial dysfunction and inflammation in rat brain Guo, Lin; Zhu, Na; Guo, Zhen Journal of Hazardous Materials, Vol. 213-214 https://doi.org/10.1016/j.jhazmat.2012.01.034	journal	April 2012
Nitric oxide and cardiac function Rastaldo, R.; Pagliaro, P.; Cappello, S. Life Sciences, Vol. 81, Issue 10 https://doi.org/10.1016/j.lfs.2007.07.019	journal	August 2007
Clinical trials with endothelin receptor antagonists: What went wrong and where can we improve? Kohan, Donald E.; Cleland, John G.; Rubin, Lewis J. Life Sciences, Vol. 91, Issue 13-14 https://doi.org/10.1016/j.lfs.2012.07.034	journal	October 2012
Endothelin1 activates and sensitizes human C-nociceptors Namer, Barbara; Hilliges, Marita; Ørstavik, Kristin Pain, Vol. 137, Issue 1 https://doi.org/10.1016/j.pain.2007.08.008	journal	January 2008
Differential pulmonary and cardiac effects of pulmonary exposure to a panel of particulate matter-associated metals Wallenborn, J. Grace; Schladweiler, Mette J.; Richards, Judy H. Toxicology and Applied Pharmacology, Vol. 241, Issue 1 https://doi.org/10.1016/j.taap.2009.08.003	journal	November 2009
Statins attenuate the development of atherosclerosis and endothelial dysfunction induced by exposure to urban particulate matter (PM10) Miyata, Ryohei; Hiraiwa, Kunihiko; Cheng, Jui Chih Toxicology and Applied Pharmacology, Vol. 272, Issue 1 https://doi.org/10.1016/j.taap.2013.05.033	journal	October 2013
Examination of mRNA expression in rat hearts and lungs for analysis of effects of exposure to concentrated ambient particles on cardiovascular function Ito, Tsuyoshi; Suzuki, Tadao; Tamura, Kumiko Toxicology, Vol. 243, Issue 3 https://doi.org/10.1016/j.tox.2007.10.013	journal	January 2008
Increased vascular contractility in isolated vessels from cigarette smoking rats is mediated by basal endothelin release Rahman, Mohammad M.; Elmi, Shahrzad; Chang, Thomas K. H. Vascular Pharmacology, Vol. 46, Issue 1 https://doi.org/10.1016/j.vph.2006.06.006	journal	January 2007
Endothelin-1 induced hypertrophic effect in neonatal rat cardiomyocytes: Involvement of Na+/H+ and Na+/Ca2+ exchangers Dulce, Raúl A.; Hurtado, Cecilia; Ennis, Irene L. Journal of Molecular and Cellular Cardiology, Vol. 41, Issue 5 https://doi.org/10.1016/j.yjmcc.2006.05.016	journal	November 2006
The Discovery of N -[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]- N ′-propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor Antagonist Bolli, Martin H.; Boss, Christoph; Binkert, Christoph Journal of Medicinal Chemistry, Vol. 55, Issue 17 https://doi.org/10.1021/jm3009103	journal	August 2012
Thromboxane and prostacyclin release from ischaemic myocardium in relation to arrhythmias Coker, Susan J.; Parratt, J. R.; Ledingham, I. McA. Nature, Vol. 291, Issue 5813 https://doi.org/10.1038/291323a0	journal	May 1981
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor Palmer, R. M. J.; Ferrige, A. G.; Moncada, S. Nature, Vol. 327, Issue 6122 https://doi.org/10.1038/327524a0	journal	June 1987
A novel potent vasoconstrictor peptide produced by vascular endothelial cells Yanagisawa, Masashi; Kurihara, Hiroki; Kimura, Sadao Nature, Vol. 332, Issue 6163 https://doi.org/10.1038/332411a0	journal	March 1988
Cloning and expression of a cDNA encoding an endothelin receptor Arai, Hiroshi; Hori, Seiji; Aramori, Ichiro Nature, Vol. 348, Issue 6303 https://doi.org/10.1038/348730a0	journal	December 1990
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor Sakurai, Takeshi; Yanagisawa, Masashi; Takuwat, Yoh Nature, Vol. 348, Issue 6303 https://doi.org/10.1038/348732a0	journal	December 1990
Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist Clozel, Martine; Breu, Volker; Burri, Kaspar Nature, Vol. 365, Issue 6448 https://doi.org/10.1038/365759a0	journal	October 1993
Inhibition of myocardial endothelin pathway improves long-term survival in heart failure Sakai, Satoshi; Miyauchi, Takashi; Kobayashi, Masahiko Nature, Vol. 384, Issue 6607 https://doi.org/10.1038/384353a0	journal	November 1996
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals Jaenisch, Rudolf; Bird, Adrian Nature Genetics, Vol. 33, Issue S3 https://doi.org/10.1038/ng1089	journal	March 2003
Positron emission tomography using ¹⁸ F-labelled endothelin-1 reveals prevention of binding to cardiac receptors owing to tissue-specific clearance by ET _B receptors in vivo: Dynamic PET imaging of endothelin receptors Johnström, Peter; Fryer, Tim D.; Richards, Hugh K. British Journal of Pharmacology, Vol. 144, Issue 1 https://doi.org/10.1038/sj.bjp.0706064	journal	January 2005
Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by endothelin, a complete mitogen for Rat-1 fibroblasts MacNulty, E. E.; Plevin, R.; Wakelam, M. J. O. Biochemical Journal, Vol. 272, Issue 3 https://doi.org/10.1042/bj2720761	journal	December 1990
An Association between Air Pollution and Mortality in Six U.S. Cities Dockery, Douglas W.; Pope, C. Arden; Xu, Xiping New England Journal of Medicine, Vol. 329, Issue 24 https://doi.org/10.1056/NEJM199312093292401	journal	December 1993
Endothelins Levin, Ellis Robert New England Journal of Medicine, Vol. 333, Issue 6 https://doi.org/10.1056/NEJM199508103330607	journal	August 1995
Atherosclerosis — An Inflammatory Disease Ross, Russell New England Journal of Medicine, Vol. 340, Issue 2 https://doi.org/10.1056/NEJM199901143400207	journal	January 1999
Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide. Yanagisawa, M.; Inoue, A.; Ishikawa, T. Proceedings of the National Academy of Sciences, Vol. 85, Issue 18 https://doi.org/10.1073/pnas.85.18.6964	journal	September 1988
Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. de Nucci, G.; Thomas, R.; D'Orleans-Juste, P. Proceedings of the National Academy of Sciences, Vol. 85, Issue 24 https://doi.org/10.1073/pnas.85.24.9797	journal	December 1988
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Inoue, A.; Yanagisawa, M.; Kimura, S. Proceedings of the National Academy of Sciences, Vol. 86, Issue 8 https://doi.org/10.1073/pnas.86.8.2863	journal	April 1989
Design and synthesis of a specific endothelin 1 antagonist: effects on pulmonary vasoconstriction. Spinella, M. J.; Malik, A. B.; Everitt, J. Proceedings of the National Academy of Sciences, Vol. 88, Issue 16 https://doi.org/10.1073/pnas.88.16.7443	journal	August 1991
Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro. McMahon, E. G.; Palomo, M. A.; Moore, W. M. Proceedings of the National Academy of Sciences, Vol. 88, Issue 3 https://doi.org/10.1073/pnas.88.3.703	journal	February 1991
Regulation and Intracellular Trafficking Pathways of the Endothelin Receptors Bremnes, Toril; Paasche, Joachim D.; Mehlum, Anja Journal of Biological Chemistry, Vol. 275, Issue 23 https://doi.org/10.1074/jbc.M000142200	journal	June 2000
Translocation of Ultrafine Insoluble Iridium Particles from lung Epithelium to Extrapulmonary Organs is size Dependent but very low Kreyling, W. G.; Semmler, M.; Erbe, F. Journal of Toxicology and Environmental Health, Part A, Vol. 65, Issue 20 https://doi.org/10.1080/00984100290071649	journal	October 2002
Systemic Inflammatory Response Induced by Particulate Matter air Pollution: the Importance of Bone-Marrow Stimulation Eeden, Stephan F. van; Hogg, James C. Journal of Toxicology and Environmental Health, Part A, Vol. 65, Issue 20 https://doi.org/10.1080/00984100290071685	journal	October 2002
Endothelin-1 Potentiates Smoke-Induced Acute lung Inflammation Bhavsar, Tapan M.; Liu, Xingjian; Cerreta, Joseph M. Experimental Lung Research, Vol. 34, Issue 10 https://doi.org/10.1080/01902140802389701	journal	January 2008
Pediatric Respiratory and Systemic Effects of Chronic Air Pollution Exposure: Nose, Lung, Heart, and Brain Pathology Calderón-Garcidueñas, Lilian; Franco-Lira, Maricela; Torres-Jardón, Ricardo Toxicologic Pathology, Vol. 35, Issue 1 https://doi.org/10.1080/01926230601059985	journal	January 2007
Reanalysis of the Harvard Six Cities Study, Part I: Validation and Replication Krewski, D.; Burnett, R. T.; Goldberg, M. Inhalation Toxicology, Vol. 17, Issue 7-8 https://doi.org/10.1080/08958370590929402	journal	January 2005
No Significant Translocation of Inhaled 35-nm Carbon Particles to the Circulation in Humans Wiebert, Pernilla; Sanchez-Crespo, Alejandro; Falk, Rolf Inhalation Toxicology, Vol. 18, Issue 10 https://doi.org/10.1080/08958370600748455	journal	January 2006
Systemic Inflammation, Endothelial Dysfunction, and Activation in Clinically Healthy Children Exposed to Air Pollutants Calderón-Garcidueñas, L.; Villarreal-Calderon, R.; Valencia-Salazar, G. Inhalation Toxicology, Vol. 20, Issue 5 https://doi.org/10.1080/08958370701864797	journal	January 2008
Health Effects of Ambient Particulate Matter—Biological Mechanisms and Inflammatory Responses to In Vitro and In Vivo Particle Exposures Maier, Konrad Ludwig; Alessandrini, Francesca; Beck-Speier, Ingrid Inhalation Toxicology, Vol. 20, Issue 3 https://doi.org/10.1080/08958370701866313	journal	January 2008
Mortality and Long-Term Exposure to Ambient Air Pollution: Ongoing Analyses Based on the American Cancer Society Cohort Krewski, Daniel; Burnett, Richard; Jerrett, Michael Journal of Toxicology and Environmental Health, Part A, Vol. 68, Issue 13-14 https://doi.org/10.1080/15287390590935941	journal	July 2005
Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. Ehrenreich, H.; Anderson, R. W.; Fox, C. H. Journal of Experimental Medicine, Vol. 172, Issue 6 https://doi.org/10.1084/jem.172.6.1741	journal	December 1990
Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function. Hahn, A. W.; Resink, T. J.; Scott-Burden, T. Cell Regulation, Vol. 1, Issue 9 https://doi.org/10.1091/mbc.1.9.649	journal	August 1990
Seasonal Analyses of Air Pollution and Mortality in 100 US Cities Peng, R. D.; Dominici, F.; Pastor-Barriuso, R. American Journal of Epidemiology, Vol. 161, Issue 6 https://doi.org/10.1093/aje/kwi075	journal	March 2005
Association of Particulate Air Pollution With Daily Mortality: The China Air Pollution and Health Effects Study Chen, R.; Kan, H.; Chen, B. American Journal of Epidemiology, Vol. 175, Issue 11 https://doi.org/10.1093/aje/kwr425	journal	April 2012
Eicosanoid signalling pathways in the heart Jenkins, C. M.; Cedars, A.; Gross, R. W. Cardiovascular Research, Vol. 82, Issue 2 https://doi.org/10.1093/cvr/cvn346	journal	November 2008
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use Malik, M.; Bigger, J. T.; Camm, A. J. European Heart Journal, Vol. 17, Issue 3 https://doi.org/10.1093/oxfordjournals.eurheartj.a014868	journal	March 1996
Pulmonary and Systemic Effects of Zinc-Containing Emission Particles in Three Rat Strains: Multiple Exposure Scenarios Kodavanti, U. P. Toxicological Sciences, Vol. 70, Issue 1 https://doi.org/10.1093/toxsci/70.1.73	journal	November 2002
Differential Regulation of the Lung Endothelin System by Urban Particulate Matter and Ozone Thomson, Errol; Kumarathasan, Prem; Goegan, Patrick Toxicological Sciences, Vol. 88, Issue 1 https://doi.org/10.1093/toxsci/kfi272	journal	August 2005
Nonparticulate Components of Diesel Exhaust Promote Constriction in Coronary Arteries from ApoE−/− Mice Campen, Matthew J.; Babu, N. Sathish; Helms, G. Andrew Toxicological Sciences, Vol. 88, Issue 1 https://doi.org/10.1093/toxsci/kfi283	journal	August 2005
Cardiac Oxidative Stress and Electrophysiological Changes in Rats Exposed to Concentrated Ambient Particles are Mediated by TRP-Dependent Pulmonary Reflexes Ghelfi, Elisa; Rhoden, Claudia Ramos; Wellenius, Gregory A. Toxicological Sciences, Vol. 102, Issue 2 https://doi.org/10.1093/toxsci/kfn005	journal	January 2008
C60 Exposure Augments Cardiac Ischemia/Reperfusion Injury and Coronary Artery Contraction in Sprague Dawley Rats Thompson, Leslie C.; Urankar, Rakhee N.; Holland, Nathan A. Toxicological Sciences, Vol. 138, Issue 2 https://doi.org/10.1093/toxsci/kfu008	journal	January 2014
Cellular signaling by peptides of the endothelin gene family Simonson, Michael S.; Dunn, Michael J. The FASEB Journal, Vol. 4, Issue 12 https://doi.org/10.1096/fasebj.4.12.2168326	journal	September 1990
The endogenous thrombin potential and high levels of coagulation factor VIII, factor IX and factor XI Siegemund, Annelie; Petros, Sirak; Siegemund, Thomas Blood Coagulation & Fibrinolysis, Vol. 15, Issue 3 https://doi.org/10.1097/00001721-200404000-00007	journal	January 2004
Pharmacology of Endothelin-1 in vivo in Humans Haynes, W. G.; Clarke, J. G.; Cockcroft, J. R. Journal of Cardiovascular Pharmacology, Vol. 17 https://doi.org/10.1097/00005344-199100177-00080	journal	January 1991
Regional Hemodynamic Effects and Clearance of Endothelin-1 in Humans: Renal and Peripheral Tissues May Contribute to the Overall Disposal of the Peptide Gasic, S.; Wagner, O. F.; Vierhapper, H. Journal of Cardiovascular Pharmacology, Vol. 19, Issue 2 https://doi.org/10.1097/00005344-199202000-00004	journal	January 1992
Pharmacologic Characterization of an EndothelinA (ETA) Receptor Antagonist in Conscious Rats Bazil, Michelle K.; Lappe, Rodney W.; Webb, Randy L. Journal of Cardiovascular Pharmacology, Vol. 20, Issue 6 https://doi.org/10.1097/00005344-199212000-00014	journal	January 1992
Effects of the Endothelin (ET) Receptor Antagonist BQ 123 on Initial and Delayed Vascular Responses Induced by ET-1 in Conscious, Normotensive Rats Bird, J. Eileen; Waldron, Thomas L.; Dorso, Charles R. Journal of Cardiovascular Pharmacology, Vol. 22, Issue 1 https://doi.org/10.1097/00005344-199307000-00012	journal	January 1993
The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure Kohan, Donald E. Current Opinion in Nephrology & Hypertension, Vol. 15, Issue 1 https://doi.org/10.1097/01.mnh.0000186852.15889.1a	journal	January 2006
Effects of Endothelin-1 Chronic Stimulation on Electrical Restitution, Beat-to-beat Variability of Repolarization, and Ventricular Arrhythmogenesis Liu, Tao; Qin, Mu; Shi, Shao Bo Journal of Cardiovascular Pharmacology, Vol. 62, Issue 6 https://doi.org/10.1097/FJC.0000000000000015	journal	January 2013
Effects of Indoor, Outdoor, and Personal Exposure to Particulate Air Pollution on Cardiovascular Physiology and Systemic Mediators in Seniors Liu, Ling; Ruddy, Terrence; Dalipaj, Mary Journal of Occupational & Environmental Medicine, Vol. 51, Issue 9 https://doi.org/10.1097/JOM.0b013e3181b35144	journal	January 2009
Endothelin@25 – new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR R eview 12 Maguire, J. J.; Davenport, A. P. British Journal of Pharmacology, Vol. 171, Issue 24 https://doi.org/10.1111/bph.12874	journal	November 2014
Vascular responses to endothelin-1 following inhibition of nitric oxide synthesis in the conscious rat Filep, János G.; Földes-Filep, éva; Rousseau, Anne British Journal of Pharmacology, Vol. 110, Issue 3 https://doi.org/10.1111/j.1476-5381.1993.tb13944.x	journal	November 1993
Cigarette smoke exposure up-regulates endothelin receptor B in human pulmonary artery endothelial cells: molecular and functional consequences: Cigarette smoke and endothelin B receptor Milara, J.; Ortiz, Jl; Juan, G. British Journal of Pharmacology, Vol. 161, Issue 7 https://doi.org/10.1111/j.1476-5381.2010.00979.x	journal	August 2010
Endogenous endothelin stimulates cardiac sympathetic afferents during ischaemia: Endogenous ET-1 in stimulation of cardiac afferents Fu, Liang-Wu; Guo, Zhi-Ling; Longhurst, John C. The Journal of Physiology, Vol. 588, Issue 13 https://doi.org/10.1113/jphysiol.2010.188730	journal	June 2010
Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist Iglarz, Marc; Binkert, Christoph; Morrison, Keith Journal of Pharmacology and Experimental Therapeutics, Vol. 327, Issue 3 https://doi.org/10.1124/jpet.108.142976	journal	September 2008
An epidemiological appraisal of the association between heart rate variability and particulate air pollution: a meta-analysis Pieters, Nicky; Plusquin, Michelle; Cox, Bianca Heart, Vol. 98, Issue 15 https://doi.org/10.1136/heartjnl-2011-301505	journal	May 2012
Oxidative stress: its role in air pollution and adverse health effects Kelly, F. J. Occupational and Environmental Medicine, Vol. 60, Issue 8 https://doi.org/10.1136/oem.60.8.612	journal	August 2003
The biological effects of individual-level PM _2.5 exposure on systemic immunity and inflammatory response in traffic policemen Zhao, Jinzhuo; Gao, Zhiyi; Tian, Zhenyong Occupational and Environmental Medicine, Vol. 70, Issue 6 https://doi.org/10.1136/oemed-2012-100864	journal	January 2013
Blood hypomethylation of inflammatory genes mediates the effects of metal-rich airborne pollutants on blood coagulation Tarantini, Letizia; Bonzini, Matteo; Tripodi, Armando Occupational and Environmental Medicine, Vol. 70, Issue 6 https://doi.org/10.1136/oemed-2012-101079	journal	March 2013
The endothelin system and its role in acute myocardial infarction Cernacek, Peter; Stewart, Duncan J.; Monge, Juan-Carlos Canadian Journal of Physiology and Pharmacology, Vol. 81, Issue 6 https://doi.org/10.1139/y03-052	journal	June 2003
E NDOTHELIN S YSTEM : The Double-Edged Sword in Health and Disease Kedzierski, Rafal M.; Yanagisawa, Masashi Annual Review of Pharmacology and Toxicology, Vol. 41, Issue 1 https://doi.org/10.1146/annurev.pharmtox.41.1.851	journal	April 2001
Secondhand tobacco smoke, arterial stiffness, and altered circadian blood pressure patterns are associated with lung inflammation and oxidative stress in rats Gentner, Nicole J.; Weber, Lynn P. American Journal of Physiology-Heart and Circulatory Physiology, Vol. 302, Issue 3 https://doi.org/10.1152/ajpheart.00852.2011	journal	February 2012
Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity Brutsaert, Dirk L. Physiological Reviews, Vol. 83, Issue 1 https://doi.org/10.1152/physrev.00017.2002	journal	January 2003
Contribution of Lung Macrophages to the Inflammatory Responses Induced by Exposure to Air Pollutants Hiraiwa, Kunihiko; van Eeden, Stephan F. Mediators of Inflammation, Vol. 2013 https://doi.org/10.1155/2013/619523	journal	January 2013
Recent Insights in the Paracrine Modulation of Cardiomyocyte Contractility by Cardiac Endothelial Cells Noireaud, Jacques; Andriantsitohaina, Ramaroson BioMed Research International, Vol. 2014 https://doi.org/10.1155/2014/923805	journal	January 2014
DMSO-Soluble Cigarette Smoke Particles Alter the Expression of Endothelin B Receptor in Rat Coronary Artery Huang, Lin-Hong; Zhang, Ping-An; He, Jian-Yu Journal of Vascular Research, Vol. 50, Issue 3 https://doi.org/10.1159/000350866	journal	January 2013
Passage of Inhaled Particles Into the Blood Circulation in Humans Burch, William M. Circulation, Vol. 106, Issue 20 https://doi.org/10.1161/01.CIR.0000037134.24080.42	journal	November 2002
Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease Pope, C. Arden; Burnett, Richard T.; Thurston, George D. Circulation, Vol. 109, Issue 1 https://doi.org/10.1161/01.CIR.0000108927.80044.7F	journal	January 2004
Hypertrophy of the Heart: A New Therapeutic Target? Frey, Norbert; Katus, Hugo A.; Olson, Eric N. Circulation, Vol. 109, Issue 13 https://doi.org/10.1161/01.CIR.0000120390.68287.BB	journal	April 2004
Air Pollution and Cardiovascular Disease: A Statement for Healthcare Professionals From the Expert Panel on Population and Prevention Science of the American Heart Association Brook, Robert D.; Franklin, Barry; Cascio, Wayne Circulation, Vol. 109, Issue 21 https://doi.org/10.1161/01.CIR.0000128587.30041.C8	journal	June 2004
Endothelium-Restricted Overexpression of Human Endothelin-1 Causes Vascular Remodeling and Endothelial Dysfunction Amiri, Farhad; Virdis, Agostino; Neves, Mario Fritsch Circulation, Vol. 110, Issue 15 https://doi.org/10.1161/01.CIR.0000144462.08345.B9	journal	October 2004
Endothelins and Endothelin Receptor Antagonists: Therapeutic Considerations for a Novel Class of Cardiovascular Drugs Lüscher, Thomas F.; Barton, Matthias Circulation, Vol. 102, Issue 19 https://doi.org/10.1161/01.CIR.102.19.2434	journal	November 2000
Increased Particulate Air Pollution and the Triggering of Myocardial Infarction Peters, Annette; Dockery, Douglas W.; Muller, James E. Circulation, Vol. 103, Issue 23 https://doi.org/10.1161/01.CIR.103.23.2810	journal	June 2001
Effect of endothelin-1 in man. Vierhapper, H.; Wagner, O.; Nowotny, P. Circulation, Vol. 81, Issue 4 https://doi.org/10.1161/01.CIR.81.4.1415	journal	April 1990
Plasma endothelin in chronic heart failure. McMurray, J. J.; Ray, S. G.; Abdullah, I. Circulation, Vol. 85, Issue 4 https://doi.org/10.1161/01.CIR.85.4.1374	journal	April 1992
Systemic Endothelin Receptor Blockade Decreases Peripheral Vascular Resistance and Blood Pressure in Humans Haynes, William G.; Ferro, Charles J.; O’Kane, Kevin P. J. Circulation, Vol. 93, Issue 10 https://doi.org/10.1161/01.CIR.93.10.1860	journal	May 1996
Endothelin-1 Is Involved in Norepinephrine-Induced Ventricular Hypertrophy In Vivo: Acute Effects of Bosentan, an Orally Active, Mixed Endothelin ET _A and ET _B Receptor Antagonist Kaddoura, Samer; Firth, John D.; Boheler, Kenneth R. Circulation, Vol. 93, Issue 11 https://doi.org/10.1161/01.CIR.93.11.2068	journal	June 1996
Role of Endogenous Endothelin in Chronic Heart Failure: Effect of Long-term Treatment With an Endothelin Antagonist on Survival, Hemodynamics, and Cardiac Remodeling Mulder, Paul; Richard, Vincent; Derumeaux, Geneviève Circulation, Vol. 96, Issue 6 https://doi.org/10.1161/01.CIR.96.6.1976	journal	September 1997
Endothelin-A Receptor Antagonist–Mediated Vasodilatation Is Attenuated by Inhibition of Nitric Oxide Synthesis and by Endothelin-B Receptor Blockade Verhaar, Marianne C.; Strachan, Fiona E.; Newby, David E. Circulation, Vol. 97, Issue 8 https://doi.org/10.1161/01.CIR.97.8.752	journal	March 1998
Expression of Endothelin-1, Endothelin-Converting Enzyme, and Endothelin Receptors in Chronic Heart Failure Zolk, Oliver; Quattek, Jessika; Sitzler, Gerhard Circulation, Vol. 99, Issue 16 https://doi.org/10.1161/01.CIR.99.16.2118	journal	April 1999
Endothelin. Pathways of transmembrane signaling. Simonson, M. S.; Dunn, M. J. Hypertension, Vol. 15, Issue 2_Suppl https://doi.org/10.1161/01.HYP.15.2_Suppl.I5	journal	February 1990
Potential role of endothelin in hypertension. Controversy on endothelin in hypertension. Lüscher, T. F.; Seo, B. G.; Bühler, F. R. Hypertension, Vol. 21, Issue 6_pt_1 https://doi.org/10.1161/01.HYP.21.6.752	journal	June 1993
Effects of endothelin on coronary flow, mechanical performance, oxygen uptake, and formation of purines and on outflow of prostacyclin in the isolated rabbit heart. Karwatowska-Prokopczuk, E.; Wennmalm, A. Circulation Research, Vol. 66, Issue 1 https://doi.org/10.1161/01.RES.66.1.46	journal	January 1990
Myocardial contractile actions of endothelin-1 in rat and rabbit papillary muscles. Role of endocardial endothelium. Li, K.; Stewart, D. J.; Rouleau, J. L. Circulation Research, Vol. 69, Issue 2 https://doi.org/10.1161/01.RES.69.2.301	journal	August 1991
Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium. Boulanger, C. M.; Tanner, F. C.; Béa, M. L. Circulation Research, Vol. 70, Issue 6 https://doi.org/10.1161/01.RES.70.6.1191	journal	June 1992
Endothelin-1 and Angiotensin II Receptors in Cells From Rat Hypertrophied Heart: Receptor Regulation and Intracellular Ca ²⁺ Modulation Fareh, Jeannette; Touyz, Rhian M.; Schiffrin, Ernesto L. Circulation Research, Vol. 78, Issue 2 https://doi.org/10.1161/01.RES.78.2.302	journal	February 1996
Effect of carbon dioxide and oxygen on endothelin production by cultured porcine cerebral endothelial cells. Yoshimoto, S.; Ishizaki, Y.; Sasaki, T. Stroke, Vol. 22, Issue 3 https://doi.org/10.1161/01.STR.22.3.378	journal	March 1991
Blockade and Reversal of Endothelin-Induced Constriction in Pial Arteries From Human Brain Pierre, Lisa N.; Davenport, Anthony P. Stroke, Vol. 30, Issue 3 https://doi.org/10.1161/01.STR.30.3.638	journal	March 1999
Vehicular Emissions Induce Vascular MMP-9 Expression and Activity Associated With Endothelin-1–Mediated Pathways Lund, Amie K.; Lucero, JoAnn; Lucas, Selitá Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 29, Issue 4 https://doi.org/10.1161/ATVBAHA.108.176107	journal	April 2009
Particulate Matter Air Pollution and Cardiovascular Disease: An Update to the Scientific Statement From the American Heart Association Brook, Robert D.; Rajagopalan, Sanjay; Pope, C. Arden Circulation, Vol. 121, Issue 21 https://doi.org/10.1161/CIR.0b013e3181dbece1	journal	June 2010
Relationships Between Fine Particulate Air Pollution, Cardiometabolic Disorders, and Cardiovascular Mortality Pope, C. Arden; Turner, Michelle C.; Burnett, Richard T. Circulation Research, Vol. 116, Issue 1 https://doi.org/10.1161/CIRCRESAHA.116.305060	journal	January 2015
Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis Mills, Nicholas L.; Törnqvist, Håkan; Robinson, Simon D. Circulation, Vol. 112, Issue 25 https://doi.org/10.1161/CIRCULATIONAHA.105.588962	journal	December 2005
Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans Brook, Robert D.; Urch, Bruce; Dvonch, J. Timothy Hypertension, Vol. 54, Issue 3 https://doi.org/10.1161/HYPERTENSIONAHA.109.130237	journal	September 2009
Contribution of Endothelin 1 to the Vascular Effects of Diesel Exhaust Inhalation in Humans Langrish, Jeremy P.; Lundbäck, Magnus; Mills, Nicholas L. Hypertension, Vol. 54, Issue 4 https://doi.org/10.1161/HYPERTENSIONAHA.109.135947	journal	October 2009
Endothelin-1 Increases Glomerular Permeability and Inflammation Independent of Blood Pressure in the Rat Saleh, Mohamed A.; Boesen, Erika I.; Pollock, Jennifer S. Hypertension, Vol. 56, Issue 5 https://doi.org/10.1161/HYPERTENSIONAHA.110.156570	journal	November 2010
Divergent Results Using Clinic and Ambulatory Blood Pressures: Report of a Darusentan-Resistant Hypertension Trial Bakris, George L.; Lindholm, Lars H.; Black, Henry R. Hypertension, Vol. 56, Issue 5 https://doi.org/10.1161/HYPERTENSIONAHA.110.156976	journal	November 2010
Particulate Air Pollution as a Predictor of Mortality in a Prospective Study of U.S. Adults Pope, C. Arden; Thun, Michael J.; Namboodiri, Mohan M. American Journal of Respiratory and Critical Care Medicine, Vol. 151, Issue 3_pt_1 https://doi.org/10.1164/ajrccm/151.3_Pt_1.669	journal	March 1995
Ultrafine Particle Deposition and Clearance in the Healthy and Obstructed Lung Brown, James S.; Zeman, Kirby L.; Bennett, William D. American Journal of Respiratory and Critical Care Medicine, Vol. 166, Issue 9 https://doi.org/10.1164/rccm.200205-399OC	journal	November 2002
Reduction in Fine Particulate Air Pollution and Mortality: Extended Follow-up of the Harvard Six Cities Study Laden, Francine; Schwartz, Joel; Speizer, Frank E. American Journal of Respiratory and Critical Care Medicine, Vol. 173, Issue 6 https://doi.org/10.1164/rccm.200503-443OC	journal	March 2006
Deposition, Retention, and Translocation of Ultrafine Particles from the Central Airways and Lung Periphery Möller, Winfried; Felten, Kathrin; Sommerer, Knut American Journal of Respiratory and Critical Care Medicine, Vol. 177, Issue 4 https://doi.org/10.1164/rccm.200602-301OC	journal	February 2008
Long-term Ambient Fine Particulate Matter Air Pollution and Lung Cancer in a Large Cohort of Never-Smokers Turner, Michelle C.; Krewski, Daniel; Pope, C. Arden American Journal of Respiratory and Critical Care Medicine, Vol. 184, Issue 12 https://doi.org/10.1164/rccm.201106-1011OC	journal	December 2011
Spatial Analysis of Air Pollution and Mortality in California Jerrett, Michael; Burnett, Richard T.; Beckerman, Bernardo S. American Journal of Respiratory and Critical Care Medicine, Vol. 188, Issue 5 https://doi.org/10.1164/rccm.201303-0609OC	journal	September 2013
Interaction of Alveolar Macrophages and Airway Epithelial Cells Following Exposure to Particulate Matter Produces Mediators that Stimulate the Bone Marrow Fujii, Takeshi; Hayashi, Shizu; Hogg, James C. American Journal of Respiratory Cell and Molecular Biology, Vol. 27, Issue 1 https://doi.org/10.1165/ajrcmb.27.1.4787	journal	July 2002
Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells. Simonson, M. S.; Wann, S.; Mené, P. Journal of Clinical Investigation, Vol. 83, Issue 2 https://doi.org/10.1172/JCI113935	journal	February 1989
Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. Ito, H.; Hirata, Y.; Adachi, S. Journal of Clinical Investigation, Vol. 92, Issue 1 https://doi.org/10.1172/JCI116579	journal	July 1993
Suppression of endothelin-1-induced mitogenic responses of human aortic smooth muscle cells by interleukin-1 beta. Fujitani, Y.; Ninomiya, H.; Okada, T. Journal of Clinical Investigation, Vol. 95, Issue 6 https://doi.org/10.1172/JCI117948	journal	June 1995
Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation Jin, Cong; Shelburne, Christopher P.; Li, Guojie Journal of Clinical Investigation, Vol. 121, Issue 3 https://doi.org/10.1172/JCI43584	journal	March 2011
β2-Adrenergic agonists augment air pollution–induced IL-6 release and thrombosis Chiarella, Sergio E.; Soberanes, Saul; Urich, Daniela Journal of Clinical Investigation, Vol. 124, Issue 7 https://doi.org/10.1172/JCI75157	journal	May 2014
Bosentan inhibits cigarette smoke-induced endothelin receptor expression in pulmonary arteries Milara, J.; Gabarda, E.; Juan, G. European Respiratory Journal, Vol. 39, Issue 4 https://doi.org/10.1183/09031936.00021411	journal	August 2011
Liver toxicity of sitaxentan in pulmonary arterial hypertension Galie, N.; Hoeper, M. M.; Gibbs, J. S. R. European Respiratory Journal, Vol. 37, Issue 2 https://doi.org/10.1183/09031936.00194810	journal	January 2011
Negligible clearance of ultrafine particles retained in healthy and affected human lungs Wiebert, P. European Respiratory Journal, Vol. 28, Issue 2 https://doi.org/10.1183/09031936.06.00103805	journal	August 2006
Cigarette smoke exposure causes constriction of rat lung explant airways Wright, J. L.; Sun, J-P.; Churg, A. European Respiratory Journal, Vol. 14, Issue 5 https://doi.org/10.1183/09031936.99.14510959	journal	November 1999
Long-term air pollution exposure and cardio- respiratory mortality: a review Hoek, Gerard; Krishnan, Ranjini M.; Beelen, Rob Environmental Health, Vol. 12, Issue 1 https://doi.org/10.1186/1476-069X-12-43	journal	May 2013
Thoracic and respirable particle definitions for human health risk assessment Brown, James S.; Gordon, Terry; Price, Owen Particle and Fibre Toxicology, Vol. 10, Issue 1 https://doi.org/10.1186/1743-8977-10-12	journal	January 2013
Exposure to ultrafine carbon particles at levels below detectable pulmonary inflammation affects cardiovascular performance in spontaneously hypertensive rats Upadhyay, Swapna; Stoeger, Tobias; Harder, Volkar Particle and Fibre Toxicology, Vol. 5, Issue 1 https://doi.org/10.1186/1743-8977-5-19	journal	January 2008
Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs) Upadhyay, Swapna; Ganguly, Koustav; Stoeger, Tobias Particle and Fibre Toxicology, Vol. 7, Issue 1 https://doi.org/10.1186/1743-8977-7-27	journal	January 2010
Ultrafine carbon particle mediated cardiovascular impairment of aged spontaneously hypertensive rats Upadhyay, Swapna; Stoeger, Tobias; George, Leema Particle and Fibre Toxicology, Vol. 11, Issue 1 https://doi.org/10.1186/s12989-014-0036-6	journal	September 2014
Prostacyclin in Vascular Diseases - Recent Insights and Future Perspectives -: – Recent Insights and Future Perspectives – Kawabe, Jun-ichi; Ushikubi, Fumitaka; Hasebe, Naoyuki Circulation Journal, Vol. 74, Issue 5 https://doi.org/10.1253/circj.CJ-10-0195	journal	January 2010
The Arrhythmogenic Action of Endothelin in Rats Yorikane, Ryosuke; Koike, Hiroyuki Japanese Journal of Pharmacology, Vol. 53, Issue 2 https://doi.org/10.1254/jjp.53.259	journal	January 1990
Changes of Brain Endothelin Levels and Peripheral Endothelin Receptors by Chronic Cigarette Smoke in Spontaneously Hypertensive Rats Ohno, Norikazu; Tanaka, Takeshi; Kita, Taizo Journal of Pharmacological Sciences, Vol. 94, Issue 3 https://doi.org/10.1254/jphs.94.287	journal	January 2004
A Comparison of Vascular Effects from Complex and Individual Air Pollutants Indicates a Role for Monoxide Gases and Volatile Hydrocarbons Campen, Matthew J.; Lund, Amie K.; Doyle-Eisele, Melanie L. Environmental Health Perspectives, Vol. 118, Issue 7 https://doi.org/10.1289/ehp.0901207	journal	July 2010
Vascular and Cardiac Impairments in Rats Inhaling Ozone and Diesel Exhaust Particles Kodavanti, Urmila P.; Thomas, Ronald; Ledbetter, Allen D. Environmental Health Perspectives, Vol. 119, Issue 3 https://doi.org/10.1289/ehp.1002386	journal	March 2011
TRPA1 and Sympathetic Activation Contribute to Increased Risk of Triggered Cardiac Arrhythmias in Hypertensive Rats Exposed to Diesel Exhaust Hazari, Mehdi S.; Haykal-Coates, Najwa; Winsett, Darrell W. Environmental Health Perspectives, Vol. 119, Issue 7 https://doi.org/10.1289/ehp.1003200	journal	July 2011
The Role of Particulate Matter-Associated Zinc in Cardiac Injury in Rats Kodavanti, Urmila P.; Schladweiler, Mette C.; Gilmour, Peter S. Environmental Health Perspectives, Vol. 116, Issue 1 https://doi.org/10.1289/ehp.10379	journal	January 2008
Residential Exposure to Traffic-Related Air Pollution and Survival after Heart Failure Medina-Ramón, Mercedes; Goldberg, Robert; Melly, Steven Environmental Health Perspectives, Vol. 116, Issue 4 https://doi.org/10.1289/ehp.10918	journal	April 2008
Diesel Exhaust Inhalation Elicits Acute Vasoconstriction in Vivo Peretz, Alon; Sullivan, Jeffrey H.; Leotta, Daniel F. Environmental Health Perspectives, Vol. 116, Issue 7 https://doi.org/10.1289/ehp.11027	journal	July 2008
Risk of Nonaccidental and Cardiovascular Mortality in Relation to Long-term Exposure to Low Concentrations of Fine Particulate Matter: A Canadian National-Level Cohort Study Crouse, Dan L.; Peters, Paul A.; van Donkelaar, Aaron Environmental Health Perspectives, Vol. 120, Issue 5 https://doi.org/10.1289/ehp.1104049	journal	May 2012
Chronic Exposure to Fine Particles and Mortality: An Extended Follow-up of the Harvard Six Cities Study from 1974 to 2009 Lepeule, Johanna; Laden, Francine; Dockery, Douglas Environmental Health Perspectives, Vol. 120, Issue 7 https://doi.org/10.1289/ehp.1104660	journal	July 2012
Long-term Exposure to Black Carbon and Carotid Intima-Media Thickness: The Normative Aging Study Wilker, Elissa H.; Mittleman, Murray A.; Coull, Brent A. Environmental Health Perspectives, Vol. 121, Issue 9 https://doi.org/10.1289/ehp.1104845	journal	September 2013
Circulating Biomarkers of Inflammation, Antioxidant Activity, and Platelet Activation Are Associated with Primary Combustion Aerosols in Subjects with Coronary Artery Disease Delfino, Ralph J.; Staimer, Norbert; Tjoa, Thomas Environmental Health Perspectives, Vol. 116, Issue 7 https://doi.org/10.1289/ehp.11189	journal	July 2008
Association between Long-Term Exposure to Traffic-Related Air Pollution and Subclinical Atherosclerosis: The REGICOR Study Rivera, Marcela; Basagaña, Xavier; Aguilera, Inmaculada Environmental Health Perspectives, Vol. 121, Issue 2 https://doi.org/10.1289/ehp.1205146	journal	February 2013
Hemodynamic, Autonomic, and Vascular Effects of Exposure to Coarse Particulate Matter Air Pollution from a Rural Location Brook, Robert D.; Bard, Robert L.; Morishita, Masako Environmental Health Perspectives, Vol. 122, Issue 6 https://doi.org/10.1289/ehp.1306595	journal	June 2014
Long-Term Exposure to Concentrated Ambient PM _2.5 Increases Mouse Blood Pressure through Abnormal Activation of the Sympathetic Nervous System: A Role for Hypothalamic Inflammation Ying, Zhekang; Xu, Xiaohua; Bai, Yuntao Environmental Health Perspectives, Vol. 122, Issue 1 https://doi.org/10.1289/ehp.1307151	journal	January 2014
A retrospective assessment of mortality from the London smog episode of 1952: the role of influenza and pollution. Bell, Michelle L.; Davis, Devra L.; Fletcher, Tony Environmental Health Perspectives, Vol. 112, Issue 1 https://doi.org/10.1289/ehp.6539	journal	January 2004
Activation of the Stress Axis and Neurochemical Alterations in Specific Brain Areas by Concentrated Ambient Particle Exposure with Concomitant Allergic Airway Disease Sirivelu, Madhu P.; MohanKumar, Sheba M. J.; Wagner, James G. Environmental Health Perspectives, Vol. 114, Issue 6 https://doi.org/10.1289/ehp.8619	journal	June 2006
Elevated Plasma Endothelin-1 and Pulmonary Arterial Pressure in Children Exposed to Air Pollution Calderón-Garcidueñas, Lilian; Vincent, Renaud; Mora-Tiscareño, Antonieta Environmental Health Perspectives, Vol. 115, Issue 8 https://doi.org/10.1289/ehp.9641	journal	August 2007
Fine Particulate Air Pollution and the Progression of Carotid Intima-Medial Thickness: A Prospective Cohort Study from the Multi-Ethnic Study of Atherosclerosis and Air Pollution Adar, Sara D.; Sheppard, Lianne; Vedal, Sverre PLoS Medicine, Vol. 10, Issue 4 https://doi.org/10.1371/journal.pmed.1001430	journal	April 2013
ERK1/2 Signaling Dominates Over RhoA Signaling in Regulating Early Changes in RNA Expression Induced by Endothelin-1 in Neonatal Rat Cardiomyocytes Marshall, Andrew K.; Barrett, Oliver P. T.; Cullingford, Timothy E. PLoS ONE, Vol. 5, Issue 4 https://doi.org/10.1371/journal.pone.0010027	journal	April 2010
Endothelin-1 in Paraventricular Nucleus Modulates Cardiac Sympathetic Afferent Reflex and Sympathetic Activity in Rats Chen, Ai-Dong; Xiong, Xiao-Qing; Gan, Xian-Bing PLoS ONE, Vol. 7, Issue 7 https://doi.org/10.1371/journal.pone.0040748	journal	July 2012
Elevation of Serum Endothelins and Cardiotoxicity Induced by Particulate Matter (PM_2.5) in Rats with Acute Myocardial Infarction Kang, Y. James; Li, Yan; Zhou, Zhanxiang Cardiovascular Toxicology, Vol. 2, Issue 4 https://doi.org/10.1385/CT:2:4:253	journal	January 2002
Fresh Gasoline Emissions, Not Paved Road Dust, Alter Cardiac Repolarization in ApoE^−/− Mice Campen, Matthew J.; McDonald, Jacob D.; Reed, Matthew D. Cardiovascular Toxicology, Vol. 6, Issue 3-4 https://doi.org/10.1385/CT:6:3:199	journal	January 2006
Bosentan: a dual endothelin receptor antagonist Roux, Sébastien; Rubin, Lewis J. Expert Opinion on Investigational Drugs, Vol. 11, Issue 7 https://doi.org/10.1517/13543784.11.7.991	journal	July 2002
Avosentan Reduces Albumin Excretion in Diabetics with Macroalbuminuria Wenzel, René R.; Littke, Thomas; Kuranoff, Susan Journal of the American Society of Nephrology, Vol. 20, Issue 3 https://doi.org/10.1681/ASN.2008050482	journal	January 2009
Avosentan for Overt Diabetic Nephropathy Mann, Johannes F. E.; Green, Damian; Jamerson, Kenneth Journal of the American Society of Nephrology, Vol. 21, Issue 3 https://doi.org/10.1681/ASN.2009060593	journal	February 2010
Preferential recruitment of neutrophils by endothelin-1 in acute lung inflammation induced by lipopolysaccharide or cigarette smoke Cantor, Jerome International Journal of Chronic Obstructive Pulmonary Disease, Vol. Volume 3 https://doi.org/10.2147/COPD.S2837	journal	January 2008
Impact of Matrix Metalloproteinases on Atherosclerosis Lin, Juntang; Kakkar, Vijay; Lu, Xinjie Current Drug Targets, Vol. 15, Issue 4 https://doi.org/10.2174/1389450115666140211115805	journal	March 2014
Recent Developments on Endothelin Antagonists as Immunomodulatory Drugs - from Infection to Transplantation Medicine Nett, Philipp; Teixeira, Mauro; Candinas, Daniel Recent Patents on Cardiovascular Drug Discovery, Vol. 1, Issue 3 https://doi.org/10.2174/157489006778776990	journal	November 2006
Fog and Deaths in London, December 1952 Scott, John A. Public Health Reports (1896-1970), Vol. 68, Issue 5 https://doi.org/10.2307/4588454	journal	January 1953
Endothelin Limits Insulin Action in Obese/Insulin-Resistant Humans Lteif, A.; Vaishnava, P.; Baron, A. D. Diabetes, Vol. 56, Issue 3 https://doi.org/10.2337/db06-1406	journal	February 2007
Inflammatory response to acute exposure to welding fumes during the working day Järvelä, Merja; Kauppi, Paula; Tuomi, Timo International Journal of Occupational Medicine and Environmental Health, Vol. 26, Issue 2 https://doi.org/10.2478/s13382-013-0097-z	journal	January 2013
Role of oxidative damage in toxicity of particulates Møller, Peter; Jacobsen, Nicklas R.; Folkmann, Janne K. Free Radical Research, Vol. 44, Issue 1 https://doi.org/10.3109/10715760903300691	journal	November 2009
Beneficial effects of melatonin and BQ-123 on the rat testis damagecaused by cigarette smoke Aslan, Hüseyin; KesİCİ, Hakan; Karaca, Zafer İsmail TURKISH JOURNAL OF MEDICAL SCIENCES, Vol. 45 https://doi.org/10.3906/sag-1312-66	journal	January 2015
Chemicals in Diesel Exhaust Particles Generate Reactive Oxygen Radicals and Induce Apoptosis in Macrophages Hiura, Timothy S.; Kaszubowski, Martin P.; Li, Ning The Journal of Immunology, Vol. 163, Issue 10 https://doi.org/10.4049/jimmunol.163.10.5582	journal	November 1999

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